Photodynamic Therapy and Hyperthermia in Combination Treatment—Neglected Forces in the Fight against Cancer

Bienia, Aleksandra; Wiecheć-Cudak, Olga; Murzyn, Aleksandra Anna; Krzykawska-Serda, Martyna

doi:10.3390/pharmaceutics13081147

Cited by 25 publications

(10 citation statements)

References 287 publications

(245 reference statements)

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“…There is a wealth of literature demonstrating that the combination of PDT with PTT or mild hyperthermia synergistically enhances tumor cell killing. − A study by Christensen and coauthors described the synergistic relationship between mild hyperthermia and PDT in vitro . Water bath heating to 41, 42.5 and 45 °C increased cell sensitivity to PDT-induced cell death.…”

Section: Pdt and Ptt Biological Interplaymentioning

confidence: 99%

Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine

et al. 2023

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Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen species or increasing temperature. Great strides have been made in understanding biological effects of PDT and PTT at the cellular, vascular and tumor microenvironmental levels, as well as translating both modalities in the clinic. Emerging evidence suggests that PDT and PTT may synergize due to their different mechanisms of action, and their nonoverlapping toxicity profiles make such combination potentially efficacious. Moreover, PDT/PTT combinations have gained momentum in recent years due to the development of multimodal nanoplatforms that simultaneously incorporate photodynamically- and photothermally active agents. In this review, we discuss how combining PDT and PTT can address the limitations of each modality alone and enhance treatment safety and efficacy. We provide an overview of recent literature featuring dual PDT/PTT nanoparticles and analyze the strengths and limitations of various nanoparticle design strategies. We also detail how treatment sequence and dose may affect cellular states, tumor pathophysiology and drug delivery, ultimately shaping the treatment response. Lastly, we analyze common experimental design pitfalls that complicate preclinical assessment of PDT/PTT combinations and propose rational guidelines to elucidate the mechanisms underlying PDT/PTT interactions.

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Section: Pdt and Ptt Biological Interplaymentioning

confidence: 99%

Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine

et al. 2023

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“…Magnetic nanotheranostics, which, along with diagnostics, also includes the treatment of malignant neoplasms using targeted MNPs [7,[13][14][15][16][17][18][19][20], has several advantages over laser photodynamic therapy methods e.g. [21][22][23][24], as well as chemical e.g. [24], hydrodynamic [25][26][27][28][29] and radiation effects on the organism.…”

Section: Theranostics With Functionalized Magnetic Nanoparticlesmentioning

confidence: 99%

“…[21][22][23][24], as well as chemical e.g. [24], hydrodynamic [25][26][27][28][29] and radiation effects on the organism. The laser radiation intensity must be controlled to prevent intense heating of the nanoparticles accompanied by a loss of their resonance properties [30][31][32].…”

Section: Theranostics With Functionalized Magnetic Nanoparticlesmentioning

confidence: 99%

Towards understanding the triggering of the malignant cell death in high-efficiency magneto-mechanical anticancer therapy

Semina¹,

Isaev²,

Комогорцев³

et al. 2023

J. Phys. D: Appl. Phys.

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The paper discusses schemes for the implementation of magneto-mechanical anticancer therapy and the most probable scenarios of damaging mechanical eﬀects on the membranes of malignant cells by targeted magnetic nanoparticles selectively bound to membrane mechanoreceptors employing aptamers. The conditions for selective triggering of the malignant cell apoptosis in a low-frequency non-heating alternating magnetic ﬁeld, corresponding to the exceeding threshold value of the force acting on the membrane and its mechanoreceptors, are established using a nanoparticle dynamic simulation. The requirements for the functionality of magnetic nanoparticles and their suitability for biomedical applications are analysed. Attention is paid to the possibility of the formation of magnetite nanoparticle aggregates in an external magnetic ﬁeld and their localization near tumor cell membranes. It is shown that the scenario involving the process of aggregation of magnetite nanoparticles provides a suﬃcient magneto-mechanical impact to achieve a therapeutic eﬀect. A possible explanation for the experimentally established fact of successful application of magneto-mechanical therapy using magnetite nanoparticles is presented, in which complete suppression of the Ehrlich carcinoma in an alternating magnetic ﬁeld as a response to a magnetome-chanical stimulus was demonstrated. This result conﬁrmed the possibility of using the method for high eﬃciency treatment of malignant neoplasms. The paper is provided with an extensive review of key publications and the state of art in this area.

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“…The PDT process includes three key components-a photosensitizer (PS), a light source of the ideal wavelength, and reactive oxygen species (ROS). [12][13][14] When the PS is irradiated by a laser of a specic wavelength, it can transfer energy to oxygen or oxygen-containing groups in the surrounding environment, and nally generates ROS. [15][16][17][18][19] PDT exhibited superiority such as minimal invasiveness, favourable safety, fewer side effects, good repeatability, and relatively low cost.…”

Section: Introductionmentioning

confidence: 99%