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citations
Cited by 26 publications
(21 citation statements)
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References 59 publications
(21 reference statements)
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“…Signals from reproductive tissues regulate the lifespan of many organisms [ 32 ]. Germline signals regulate stress resistance, lipid metabolism, and lifespan through nuclear transcription factors DAF-16, DAF-12, and NHR-80 [ 33 35 ]. Here, to test if SDG could affect the transcriptional activity of these transcription factors, we analyzed the mRNA level of genes downstream of DAF-16, DAF-12, and NHR-80 in C. elegans , including sod-3 , fard-1 , and fat-6 [ 36 ], respectively.…”
Section: Resultsmentioning
confidence: 99%
“…Signals from reproductive tissues regulate the lifespan of many organisms [ 32 ]. Germline signals regulate stress resistance, lipid metabolism, and lifespan through nuclear transcription factors DAF-16, DAF-12, and NHR-80 [ 33 35 ]. Here, to test if SDG could affect the transcriptional activity of these transcription factors, we analyzed the mRNA level of genes downstream of DAF-16, DAF-12, and NHR-80 in C. elegans , including sod-3 , fard-1 , and fat-6 [ 36 ], respectively.…”
Section: Resultsmentioning
confidence: 99%
“…Therefore, ROS production is studied, as it can be a highly sensitive endpoint used for bio-safety assessment of specific NPs in C. elegans [31]. In the present study, any of the tested NPs produced ROS accumulation, even when oxidative stress damage presents the prime mechanism causing toxic effects after testing other different nanoparticles [31,52]. This clearly indicates that ROS production may be specific and will not only depend on NP size, but also on NP chemical composition.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, none of the NPs suppressed the reproductive process in C. elegans , implying no toxicity or different effects on worms’ reproduction. Nevertheless, the worms may have been affected by the undoped NPs through the sequential development period, including spermatogenesis, gonadogenesis and oogenesis by inducing aging of the reproductive system [52]. It is also important to consider that C. elegans has the capacity to adapt or acclimate to the presence of NPs across multiple generations [31].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The survival and reproduction followed a similar response pattern and, hence, effects on reproduction appear to be a direct consequence of decreased survival rather than a specific reproductive impairment. In C. elegans , and as opposed to this, Kim et al (2018) suggested that GO exposure caused reproductive toxicity by suppressing spermatogenesis of C. elegans hermaphrodites during development, resulting in decreased sperm numbers and progeny numbers [28].…”
Section: Discussionmentioning
confidence: 99%