Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan of<i>Caenorhabditis elegans</i>via DAF-16 and HSF-1

Lu, Min; Tan, Lin; Zhou, Xiao-Gang; Yang, Zhonglin; Zhu, Qing; Chen, Jianning; Luo, Huai Rong; Wu, Gui-Sheng

doi:10.1155/2020/1293935

Cited by 15 publications

(14 citation statements)

References 57 publications

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“…The plates were supplemented with 20 μ M of 5-fluoro-2'-deoxyuridine (FUdR) to inhibit oviposition and hatching. The day when Caenorhabditis elegans was transferred to the plates was recorded as the 0th day of the experiment [ 17 ]. To ensure that trigonelline retained its potency throughout the entire experiment, worms were transferred to fresh plates with or without trigonelline every other day.…”

Section: Methodsmentioning

confidence: 99%

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Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age-Related Diseases by Activating AMPK, DAF-16, and HSF-1

Zeng

Tan

Han

et al. 2021

Oxidative Medicine and Cellular Longevity

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Trigonelline is the main alkaloid with bioactivity presented in fenugreek, which was used in traditional medicine in Asian countries for centuries. It is reported that trigonelline has anti-inflammatory, anti-oxidant, and anti-pathogenic effects. We are wondering whether trigonelline have anti-aging effect. We found that 50 μM of trigonelline had the best anti-aging activity and could prolong the lifespan of Caenorhabditis elegans (C. elegans) by about 17.9%. Trigonelline can enhance the oxidative, heat, and pathogenic stress resistance of C. elegans. Trigonelline could also delay the development of neurodegenerative diseases, such as AD, PD, and HD, in models of C. elegans. Trigonelline could not prolong the lifespan of long-lived worms with loss-of-function mutations in genes regulating energy and nutrition, such as clk-1, isp-1, eat-2, and rsks-1. Trigonelline requires daf-16, hsf-1, and aak-2 to extend the lifespan of C. elegans. Trigonelline can also up-regulate the expression of daf-16 and hsf-1 targeted downstream genes, such as sod-3, gst-4, hsp-16.1, and hsp-12.6. Our results can be the basis for developing trigonelline-rich products with health benefits, as well as for further research on the pharmacological usage of trigonelline.

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Section: Methodsmentioning

confidence: 99%

“…For the pathogenic stress test, the pre-treatment was the same as high temperature resistance test. On the 10th day of the adulthood, the worms were transferred to the NGM plates covered with bacteria Pseudomonas aeruginosa [ 17 ]. The death of worms was observed and recorded every 12 hours.…”

Section: Methodsmentioning

confidence: 99%

Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age-Related Diseases by Activating AMPK, DAF-16, and HSF-1

Zeng

Tan

Han

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…Lu et al confirmed the promising attributes of the phytoestrogen secoisolariciresinol diglucoside (SDG) with regard to the health of Caenorhabditis elegans. The authors found that SDG can prolong the lifespan of C. elegans by up to 22.0%, decrease the lethality of oxidative stress and heat, reduce body movement decline linked to age, assuage dopamine nervous deterioration encouraged by 6 hydroxydopamine (6-OHDA), and reduce the toxicity of Aβ protein in C. elegans [115]. Resveratrol, a polyphenol in red wine, is a well-researched biomolecule that is reported to improve brain health by acting as an inhibitor of beta amyloid protein aggregation [116,117].…”

Section: Oxidative Stress and Brain Healthmentioning

confidence: 99%

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Samtiya

Aluko

Dhewa

et al. 2021

Foods

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Plant foods are consumed worldwide due to their immense energy density and nutritive value. Their consumption has been following an increasing trend due to several metabolic disorders linked to non-vegetarian diets. In addition to their nutritive value, plant foods contain several bioactive constituents that have been shown to possess health-promoting properties. Plant-derived bioactive compounds, such as biologically active proteins, polyphenols, phytosterols, biogenic amines, carotenoids, etc., have been reported to be beneficial for human health, for instance in cases of cancer, cardiovascular diseases, and diabetes, as well as for people with gut, immune function, and neurodegenerative disorders. Previous studies have reported that bioactive components possess antioxidative, anti-inflammatory, and immunomodulatory properties, in addition to improving intestinal barrier functioning etc., which contribute to their ability to mitigate the pathological impact of various human diseases. This review describes the bioactive components derived from fruit, vegetables, cereals, and other plant sources with health promoting attributes, and the mechanisms responsible for the bioactive properties of some of these plant components. This review mainly compiles the potential of food derived bioactive compounds, providing information for researchers that may be valuable for devising future strategies such as choosing promising bioactive ingredients to make functional foods for various non-communicable disorders.

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“…As lifespan extension is closely associated with enhanced survival under exposure to different stressors [55], next, we examined whether Reb A supplementation altered the capacity of worms to withstand heat stress and oxidative stress. After exposing 5-day-old adult worms to heat stress (i.e., 35 • C for 5 h) and following a recovery period at 20 • C for 96 h, there was no obvious difference in survival rates between Reb A-treated group and control group ( Figure 3A).…”

Section: Reb a Enhances Resistance To Oxidative Stress In C Elegansmentioning

confidence: 99%

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans

Wang

Lam

et al. 2021

Antioxidants

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Non-nutritive sweeteners are widely used in food and medicines to reduce energy content without compromising flavor. Herein, we report that Rebaudioside A (Reb A), a natural, non-nutritive sweetener, can extend both the lifespan and healthspan of C. elegans. The beneficial effects of Reb A were principally mediated via reducing the level of cellular reactive oxygen species (ROS) in response to oxidative stress and attenuating neutral lipid accumulation with aging. Transcriptomics analysis presented maximum differential expression of genes along the target of rapamycin (TOR) signaling pathway, which was further confirmed by quantitative real-time PCR (qPCR); while lipidomics uncovered concomitant reductions in the levels of phosphatidic acids (PAs), phosphatidylinositols (PIs) and lysophosphatidylcholines (LPCs) in worms treated with Reb A. Our results suggest that Reb A attenuates aging by acting as effective cellular antioxidants and also in lowering the ectopic accumulation of neutral lipids.

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Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan ofCaenorhabditis elegansvia DAF-16 and HSF-1

Cited by 15 publications

References 57 publications

Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age-Related Diseases by Activating AMPK, DAF-16, and HSF-1

Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age-Related Diseases by Activating AMPK, DAF-16, and HSF-1

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans

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