Graphene oxide/manganese ferrite nanohybrids for magnetic resonance imaging, photothermal therapy and drug delivery

Yang, Yan; Shi, Haili; Wang, Yapei; Shi, Benzhao; Guo, Linlin; Wu, Dongmei; Yang, Shiping; Wu, Huixia

doi:10.1177/0885328215601926

Cited by 50 publications

(18 citation statements)

References 48 publications

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“…IONs can be combined with other inorganic nanoparticles such as molybdenum sulfide [ 72 , 73 ], manganese [ 74 ], copper/selenium [ 75 , 76 ], graphene oxides [ 77 , 78 ], manganese and graphene oxide [ 79 ], Prussian blue [ 80 , 81 ], and copper sulfide [ 82 ].…”

Section: Iron Oxide Nanoparticles For Photothermal Therapymentioning

confidence: 99%

Iron Oxide Nanoparticles in Photothermal Therapy

2018

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Photothermal therapy is a kind of therapy based on increasing the temperature of tumoral cells above 42 °C. To this aim, cells must be illuminated with a laser, and the energy of the radiation is transformed in heat. Usually, the employed radiation belongs to the near-infrared radiation range. At this range, the absorption and scattering of the radiation by the body is minimal. Thus, tissues are almost transparent. To improve the efficacy and selectivity of the energy-to-heat transduction, a light-absorbing material, the photothermal agent, must be introduced into the tumor. At present, a vast array of compounds are available as photothermal agents. Among the substances used as photothermal agents, gold-based compounds are one of the most employed. However, the undefined toxicity of this metal hinders their clinical investigations in the long run. Magnetic nanoparticles are a good alternative for use as a photothermal agent in the treatment of tumors. Such nanoparticles, especially those formed by iron oxides, can be used in combination with other substances or used themselves as photothermal agents. The combination of magnetic nanoparticles with other photothermal agents adds more capabilities to the therapeutic system: the nanoparticles can be directed magnetically to the site of interest (the tumor) and their distribution in tumors and other organs can be imaged. When used alone, magnetic nanoparticles present, in theory, an important limitation: their molar absorption coefficient in the near infrared region is low. The controlled clustering of the nanoparticles can solve this drawback. In such conditions, the absorption of the indicated radiation is higher and the conversion of energy in heat is more efficient than in individual nanoparticles. On the other hand, it can be designed as a therapeutic system, in which the heat generated by magnetic nanoparticles after irradiation with infrared light can release a drug attached to the nanoparticles in a controlled manner. This form of targeted drug delivery seems to be a promising tool of chemo-phototherapy. Finally, the heating efficiency of iron oxide nanoparticles can be increased if the infrared radiation is combined with an alternating magnetic field.

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Section: Iron Oxide Nanoparticles For Photothermal Therapymentioning

confidence: 99%

Iron Oxide Nanoparticles in Photothermal Therapy

2018

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“…Some researchers illustrated that the Mn-ferrite (MnFe 2 O 4 ) decorated GO nanocomposites for clinical applications [49]. It was revealed that the magnetic properties of the ferrites could be effectively used as an superlative hyperthermia and T2 contrast MRI agent.…”

Section: Graphene-based Nanocomposites For Biomedical Applicationsmentioning

confidence: 99%

Development of graphene based nanocomposites towards medical and biological applications

Mousavi

Low

Hashemi

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Graphene and its derivative materials present high potential towards medical and biological applications, including drug delivery and bioimaging, due to their exceptional properties such as thermal conductivity and high specific surface area. The main focus of this work is to review the current development of graphene materials and the derivatives for biocompatible, bioimaging and drug delivery applications. Also, the synthesis methods with variation of graphene nanocomposites and the functionalisation will be further explained. For the graphene approaches, chemical vapour deposition (CVD) is the best-known technique to make high-quality graphene sheet by growth route with mass production. By considering the organic graphene nanocomposites, the biocompatibility and cytotoxic effects against graphene nanocomposites were evaluated for biomedical employments such as high quality bioimaging and effective drug delivery for cancer treatments. For example, graphene oxide incorporated with PEG and loaded with SN 38 for camptothecin analolgue as anticancer drug and revealed high cytotoxicity has an effect of 1000 times better effect than CPT in HCT-116 cells. Their drug delivery ability for both in-vivo and in-vitro applications compared to the controlled drugs such as doxorubicin (DOX) will be discussed accordingly. The graphene and its deriavatives possess some intriguing properties, which will lead to drug delivery due to strong biocompatibility and cyctotoxic effect towards biomedicine applications.

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“…In addition, compared to other carbon nanomaterials, graphene oxide has many merits, such as outstanding water solubility and physicochemical stability owing to its oxygen functional groups, and easy to obtain because of an abundant and low manufacture cost material. [56][57][58][59] Application of UMTD in Tumor Treatment Tumor…”

Section: Photosensitive Ultrasound Contrast Agentmentioning

confidence: 99%

<p>New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer</p>

Tian

Liu

Tan

et al. 2020

IJN

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Ultrasound-mediated targeted delivery (UMTD), a novel delivery modality of therapeutic materials based on ultrasound, shows great potential in biomedical applications. By coupling ultrasound contrast agents with therapeutic materials, UMTD combines the advantages of ultrasound imaging and carrier, which benefit deep tissue penetration and high concentration aggregation. In this paper we introduced recent advances in ultrasound contrast agents and applications in tumor therapy. Ultrasound contrast agents were categorized by their functions, mainly including thermosensitive, pH-sensitive and photosensitive ultrasound contrast agents. The various applications of UMTD in tumor treatment were summarized as follows: drug therapy, transfection of anti-oncogene, RNA interference, vaccine immunotherapy, monoclonal antibody immunotherapy, adoptive cellular immunotherapy, cytokine immunotherapy, and so on. In the end, we elaborated on the current challenges and provided perspectives of UMTD for clinical applications.

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Graphene oxide/manganese ferrite nanohybrids for magnetic resonance imaging, photothermal therapy and drug delivery

Cited by 50 publications

References 48 publications

Iron Oxide Nanoparticles in Photothermal Therapy

Iron Oxide Nanoparticles in Photothermal Therapy

Development of graphene based nanocomposites towards medical and biological applications

<p>New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer</p>

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