Graphene oxide-labeled sandwich-type impedimetric immunoassay with sensitive enhancement based on enzymatic 4-chloro-1-naphthol oxidation

Hou, Li; Cui, Yuling; Xu, Mingdi; Gao, Zhuangqiang; Huang, Jianxin; Tang, Dianping

doi:10.1016/j.bios.2013.02.035

Cited by 63 publications

(29 citation statements)

References 39 publications

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“…At the electrode-solution interface, there are two ways in which electricity can flow through the electrode: when the electrons are transferred to the electrodes by means of redox reactions it is called a Faradaic process and behaves according to Faraday's law. When no charge is transferred to the electrode surface, however, electricity can flow through since the system behave as a capacitor, it is called a non-Faradaic process [45,46].…”

Section: Electrochemistry At Electrode Surfacementioning

confidence: 99%

A review on impedimetric immunosensors for pathogen and biomarker detection

Leva-Bueno

Peyman

Millner

2020

Med Microbiol Immunol

127

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Since the discovery of antibiotics in the first quarter of the twentieth century, their use has been the principal approach to treat bacterial infection. Modernized medicine such as cancer therapy, organ transplantation or advanced major surgeries require effective antibiotics to manage bacterial infections. However, the irresponsible use of antibiotics along with the lack of development has led to the emergence of antimicrobial resistance which is considered a serious global threat due to the rise of multidrug-resistant bacteria (Wang et al. in Antibiotic resistance: a rundown of a global crisis, pp. 1645-1658, 2018). Currently employed diagnostics techniques are microscopy, colony counting, ELISA, PCR, RT-PCR, surface-enhanced Raman scattering and others. These techniques provide satisfactory selectivity and sensitivity (Joung et al. in Sens Actuators B Chem 161:824-831, 2012). Nevertheless, they demand specialized personnel and expensive and sophisticated machinery which can be labour-intensive and time-consuming, (

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Section: Electrochemistry At Electrode Surfacementioning

confidence: 99%

A review on impedimetric immunosensors for pathogen and biomarker detection

Leva-Bueno

Peyman

Millner

2020

Med Microbiol Immunol

127

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“…After antigens binding to the antibodies, the access of the redox probes is hindered to a higher degree than in the absence of antigens. Since the Faradic reaction of a redox couple hinders increasingly, the electron transfer resistance will increase and the capacitance will decrease (Hou et al 2013).…”

Section: Antibody-antigen Based Impedimetric Immunosensorsmentioning

confidence: 99%

A review on impedimetric biosensors

Bahadır

Sezgintürk

2014

Artificial Cells, Nanomedicine, and Biotechnology

215

131

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Electrochemical impedance spectroscopy (EIS) is a sensitive technique for the analysis of the interfacial properties related to biorecognition events such as reactions catalyzed by enzymes, biomolecular recognition events of specific binding proteins, lectins, receptors, nucleic acids, whole cells, antibodies or antibody-related substances, occurring at the modified surface. Many studies on impedimetric biosensors are focused on immunosensors and aptasensors. In impedimetric immunosensors, antibodies and antigens are bound each other and thus immunocomplex is formed and the electrode is coated with a blocking layer. As a result of that electron transfer resistance increases. In impedimetric aptasensors, impedance changes following the binding of target sequences, conformational changes, or DNA damages. Impedimetric biosensors allow direct detection of biomolecular recognition events without using enzyme labels. In this paper, impedimetric biosensors are reviewed and the most interesting ones are discussed.

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“…With respect to IgG [187] and thrombin [188], thermally reduced graphene materials should be used whereas GO offers the most sensitive platform for aptamer-based sensors. Of particular interest is the use of GO as a signal carrier enhancer in a sandwich-type immunosensor [189]. In this approach, anti-carcinoembryonic antigen (CEA) antibodies are on an AuNP-modified GCE.…”

Section: 2mentioning

confidence: 99%