Graphene oxide–Fe₃O₄ nanocomposite for combination of dual-drug chemotherapy with photothermal therapy

Abstract

A graphene oxide–Fe3O4 nanocomposite against drug-resistant tumors by the combination of dual-drug chemotherapy and photothermal therapy with NIR.

Design, Synthesis, and Characterization of Graphene–Nanoparticle Hybrid Materials for Bioapplications

“…231 Last, the codelivery of multiple anticancer drugs, camptothecin (CPT) and methotrexate (MTX), using IONP–GO hybrids in combination with NIR-induced PTT was recently demonstrated in vivo to achieve a tumor inhibitory rate of 73.9% in S-180 sarcoma-bearing Balb/c mice. 232 …”

Understanding the driving forces of camptothecin interactions on the surface of nanocomposites based on graphene oxide decorated with silica nanoparticles

“…Studies related to GO materials comprising CPT as a drug host molecule are still rare and show promising results from the point of view of high encapsulation capacity. 34,35 However, the literature has reported toxic effects of GO, such as cell membrane damage and a high capacity to cause haemolysis, 30,36 thus increasing the chance of toxicity in intravenous applications. There are also studies that show opposite effects, characterized by a low haemolytic effect.…”

Recent Advances of Graphene-based Hybrids with Magnetic Nanoparticles for Biomedical Applications

“…The authors performed their successful assays both in vitro and in vivo and claimed that the whole process was highly controllable [ 36 ]. Even more, GO-IONPs hybrids were tested to co-deliver simultaneously several anticancer drugs and, in combination with NIR-induced hyperthermia, were demonstrated to achieve in vivo a tumor inhibitory rate of 73.9% [ 38 ].…”