Understanding the driving forces of camptothecin interactions on the surface of nanocomposites based on graphene oxide decorated with silica nanoparticles

Abstract

Novel nanocomposites based on graphene oxide decorated with mesoporous silica nanoparticles comprising adsorbed camptothecin antitumor drug and their drug release studies.

Targeted Gold Nanohybrids Functionalized with Folate-Hydrophobic-Quaternized Pullulan Delivering Camptothecin for Enhancing Hydrophobic Anticancer Drug Efficacy

“…Results from this study presented good NHs for the slowrelease behavior of CPT from the CPT-GNHs@FHQ-PUL, which can prevent limitations of CPT from enhancing solubility and stability of the active lactone form by encapsulation in GNHs@FHQ-PUL. The release of half of CPT at pH 7.4 was highly beneficial to decrease the inactive carboxylate form and the toxicity of CPT to normal human cells [3], corresponding very well with the MTT results.…”

“…For effective drug delivery, PUL was designed to contain three parts, including positive charges, hydrophobic molecules of p-aminobenzoic acid, and targeted ligands of folic acid. The first part increased the electrostatic interac- Nowadays, significant efforts are currently directed at the development of nanocarriers to solve these problems of unfavorable pharmacokinetic conditions [3]. Several nanocarriers are used in nanomedicine to deliver drugs into the target site via covalent and non-covalent bindings.…”

“…General treatments for lung cancer are surgery, radiotherapy, chemotherapy, and the combinations of these treatments. Among various cancer treatments, chemotherapy is the most common type of therapeutic method and consists of the application of anticancer drugs [ 3 ]. The major obstacles to effective cancer treatment are related to high toxicity to healthy cells and the acquisition of multidrug resistance [ 4 ].…”

“…The major obstacles to effective cancer treatment are related to high toxicity to healthy cells and the acquisition of multidrug resistance [ 4 ]. Some of the current challenges that limit the efficacy of many existing chemotherapeutic drugs, especially hydrophobic drugs, include poor solubility and stability in blood, low bioavailability, low anticancer activity, inferior biodistribution in the body, rapid elimination from the body, and potential to cause adverse side effects [ 3 , 5 ]. A hydrophobic anticancer drug, such as camptothecin (CPT), is used to inhibit various cancers, and its chemical structure is shown in Figure 1 .…”

“…Nowadays, significant efforts are currently directed at the development of nanocarriers to solve these problems of unfavorable pharmacokinetic conditions [ 3 ]. Several nanocarriers are used in nanomedicine to deliver drugs into the target site via covalent and non-covalent bindings.…”