Graphene oxide chronic exposure enhanced perfluorooctane sulfonate mediated toxicity through oxidative stress generation in freshwater clam Corbicula fluminea

Bi, Chunqing; Junaid, Muhammad; Liu, Yan; Guo, Wenjing; Jiang, Xilin; Pan, Baozhu; Li, Zhengguoshen; Xu, Nan

doi:10.1016/j.chemosphere.2022.134242

Cited by 17 publications

(7 citation statements)

References 67 publications

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“…and Chunqing Bi et al. have shown that few‐layered porous graphite and graphene oxide have the capability to absorb potassium perfluorobutane sulfonate [27,28] . Thus, it may be hypothesized that during the formation of the GFPA sample through the melting process in a Brabender closed mixer, GNP may have absorbed PFBS on its surface, resulting in the creation of an organo‐modified GNP.…”

Section: Resultsmentioning

confidence: 99%

“…Findings by Ting Wu et al and Chunqing Bi et al have shown that few-layered porous graphite and graphene oxide have the capability to absorb potassium perfluorobutane sulfonate. [27,28] Thus, it may be hypothesized that during the formation of the GFPA sample through the melting process in a Brabender closed mixer, GNP may have absorbed PFBS on its surface, resulting in the creation of an organo-modified GNP. The presence of PFBS could have disrupted the π-π stacking interaction, improving the dispersibility of GNP in the GFPA sample and contributing to an increase in its mechanical properties in comparison to those of the PA, GPA, and FPA samples.…”

Section: Thermal Analysis (Tg-dtg)mentioning

confidence: 99%

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Preparation of Flame Retardant Polycarbonate‐acrylonitrile Butadiene Styrene Composite using Graphene Nanoplatelets and Potassium Perfluorobutane Sulfonate Additives

et al. 2023

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A flame‐retardant composite material (designated as GFPA) was prepared by incorporating a blend of polycarbonate‐acrylonitrile butadiene styrene (PC/ABS, 80/20 wt%) and two additives of potassium perfluorobutane sulfonate (PFBS) at 0.5 wt% and graphene nanoplatelets (GNP) at 1 wt%. The structural characterization results indicated that incorporating both GNP and PFBS significantly improved the dispersibility of the additives compared to using either of them individually. Furthermore, PFBS exhibited dual properties of a flame‐retardant and PC/ABS compatibilizer, which resulted in improved flame‐retardancy and mechanical characteristics of the GFPA material. The GFPA material was found to exhibit good flame‐retardancy properties with a V‐0 rating as determined by the UL‐94 method and a limited oxygen index of 27.6 %. In addition, the GFPA material exhibited remarkably improved mechanical properties such as enhanced impact strength (1.33 times), tensile strength (3.73 times), and flexural strength (8.61 times) compared to those of the neat PC/ABS composite.

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Section: Resultsmentioning

confidence: 99%

Section: Thermal Analysis (Tg-dtg)mentioning

confidence: 99%

Preparation of Flame Retardant Polycarbonate‐acrylonitrile Butadiene Styrene Composite using Graphene Nanoplatelets and Potassium Perfluorobutane Sulfonate Additives

et al. 2023

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“…Primary cilia play crucial roles in regulating signaling pathway interactions, such as Hedgehog, WNT, and TGF-β, and organizing spatial–temporal signaling networks during development, thereby affecting various processes in embryonic development and postnatal life. , Our findings also show that the gene expression levels of the WNT ligand binding protein SFRP2 and the WNT target RUNX2 were significantly decreased, signifying disruption in the WNT signaling pathway. Notably, previous research has demonstrated cilia degradation in freshwater clams exposed to both PFOS and graphene oxide, as well as PFOS-induced disruption of ciliogenesis in developing zebrafish . In addition, PFOS was reported to increase ciliary beat frequency at 100 μM in mouse tracheal ciliary cells .…”

Section: Discussionmentioning

confidence: 96%

“…54,55 Our findings also show that the gene expression levels of the WNT ligand binding protein SFRP2 and the WNT target RUNX2 were significantly decreased, signifying disruption in the WNT signaling pathway. Notably, previous research has demonstrated cilia degradation in freshwater clams exposed to both PFOS and graphene oxide, 56 as well as PFOS-induced disruption of ciliogenesis in developing zebrafish. 57 In addition, PFOS was reported to increase ciliary beat frequency at 100 μM in mouse tracheal ciliary cells.…”

Section: Discussionmentioning

confidence: 97%

Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models

Zhao,

Yin,

Yang

et al. 2024

Environ. Sci. Technol.

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Per-and polyfluoroalkyl substances (PFAS) are extensively utilized in varieties of products and tend to accumulate in the human body including umbilical cord blood and embryos/ fetuses. In this study, we conducted an assessment and comparison of the potential early developmental toxicity of perfluorooctanoic acid (PFOA), undecafluorohexanoic acid (PFHxA), heptafluorobutyric acid, perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate, and perfluorobutyric acid at noncytotoxic concentrations relevant to human exposure using models based on human embryonic stem cells in both three-dimensional embryoid body (EB) and monolayer differentiation configurations. All six compounds influenced the determination of cell fate by disrupting the expression of associated markers in both models and, in some instances, even led to alterations in the formation of cystic EBs. The expression of cilia-related gene IFT122 was significantly inhibited. Additionally, PFOS and PFOA inhibited ciliogenesis, while PFOA specifically reduced the cilia length. Transcriptome analysis revealed that PFOS altered 1054 genes and disrupted crucial signaling pathways such as WNT and TGF-β, which play integral roles in cilia transduction and are critical for early embryonic development. These results provide precise and comprehensive insights into the potential adverse health effects of these six PFAS compounds directly concerning early human embryonic development.

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“…Some scholars have also loaded GO on CuO as a fuel additive to improve the physical and chemical properties of diesel [8], although GO has many nice features. However, some scholars have found that GO has certain harm to the ecological environment [9][10][11][12], and its main ecological harm is mainly reflected in the following two aspects: (1) mechanical damage: due to the layered structure of GO, its edge is relatively sharp, which may damage the cell membrane and cell wall after entering cell [13]; (2) oxidative stress: after GO enters cells, due to its strong oxidative ability, oxidative stress will occur in cells, resulting in cellular lipid peroxidation and DNA damage [14]. In view of the certain ecological hazards of GO, how to deal with GO has become a hot research issue once it is leaked during transportation.…”

Section: Introductionmentioning

confidence: 99%

Study on the Adsorption Performance and Adsorption Mechanism of Graphene Oxide by Red Sandstone in Aqueous Solution

Dai

Kang

et al. 2022

Adsorption Science & Technology

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In order to deal with the increasingly serious pollution of graphene oxide (GO) to the environment. In this paper, the use of red sandstone to treat GO-contaminated aqueous solution is proposed for the first time, and the adsorption capacity and adsorption mechanism of red sandstone to GO are discussed. The controlled variable method was used to explore the optimal pH, concentration, and quality of red sandstone for GO aqueous solution. The adsorption isotherm, thermodynamics, and adsorption kinetics were fitted. Adsorption characterization tests were performed using XRD, AFM, XPS, FT-IR, SAP, TEM, SAP, laser particle size analyzer, and SEM. The results show that when T = 303 K , the optimum adsorption condition of red sandstone for GO is pH = 4 , the mass of the adsorbent is 40 mg, and when the concentration of GO is 80 mg/L, the adsorption capacity is 90 mg/g. The adsorption isotherm model fits the Langmuir model. The adsorption thermodynamic experiments and fitting results show that the reaction is endothermic. XRD and FT-IR tests showed that CaCO3 in red sandstone was involved in the adsorption of GO. SEM, TEM, and AFM microscopic results showed that GO was adsorbed on the surface of red sandstone particles. The XPS test showed that Ca2+ in red sandstone and C=O bond in GO undergo ionic or coordination reaction. The adsorption kinetics fit a pseudo-second-order kinetic model. This study will provide some references for the removal of GO in the environment and the interaction mechanism with natural minerals.

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Graphene oxide chronic exposure enhanced perfluorooctane sulfonate mediated toxicity through oxidative stress generation in freshwater clam Corbicula fluminea

Cited by 17 publications

References 67 publications

Preparation of Flame Retardant Polycarbonate‐acrylonitrile Butadiene Styrene Composite using Graphene Nanoplatelets and Potassium Perfluorobutane Sulfonate Additives

Preparation of Flame Retardant Polycarbonate‐acrylonitrile Butadiene Styrene Composite using Graphene Nanoplatelets and Potassium Perfluorobutane Sulfonate Additives

Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models

Study on the Adsorption Performance and Adsorption Mechanism of Graphene Oxide by Red Sandstone in Aqueous Solution

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