Graphene-Based Magnetic Nanoparticles for Theranostics: An Overview for Their Potential in Clinical Application

Lage, Teresa Cristina Carqueijó; Rodrigues, Raquel; Catarino, Susana Oliveira; Gallo, Juan; Bañobre‐López, Manuel; Minas, Graça

doi:10.3390/nano11051073

Cited by 19 publications

(10 citation statements)

References 78 publications

(124 reference statements)

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“…Composites of magnetic nanoparticles randomly dispersed in a polymer matrix are promising materials widely applied in many engineering areas for magnetic separation, catalysis, MRI contrast agents, or electromagnetic shielding [1][2][3][4][5]. Polydimethylsiloxane (PDMS) is a suitable polymer for embedded composite materials that combine the properties of the matrix and the nanoparticles [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Influences of Dispersions’ Shapes and Processing in Magnetic Field on Thermal Conductibility of PDMS–Fe3O4 Composites

et al. 2021

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Composites of magnetite (Fe3O4) nanoparticles dispersed in a polydimethylsiloxane (PDMS) matrix were prepared by a molding process. Two types of samples were obtained by free polymerization with randomly dispersed particles and by polymerization in an applied magnetic field. The magnetite nanoparticles were obtained from magnetic micrograins of acicular goethite (α-FeOOH) and spherical hematite (α-Fe2O3), as demonstrated by XRD measurements. The evaluation of morphological and compositional properties of the PDMS:Fe3O4 composites, performed by SEM and EDX, showed that the magnetic particles were uniformly distributed in the polymer matrix. Addition of magnetic dispersions promotes an increase of thermal conductivity compared with pristine PDMS, while further orienting the powders in a magnetic field during the polymerization process induces a decrease of the thermal conductivity compared with the un-oriented samples. The shape of the magnetic dispersions is an important factor, acicular dispersions providing a higher value for thermal conductivity compared with classic commercial powders with almost spherical shapes.

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Section: Introductionmentioning

confidence: 99%

Influences of Dispersions’ Shapes and Processing in Magnetic Field on Thermal Conductibility of PDMS–Fe3O4 Composites

et al. 2021

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“…From the various multimodal nanosystems for graphene-based magnetic nanoparticles (GbMNPs) as theranostic platforms. [64,65].…”

Section: Diagnosis and Imagingmentioning

confidence: 99%

“…FLI technique is non-invasive in nature in which photons are emitted by fluorescent probes. High loading capability of GO leads to introduce FLIguided theranostic by FLI agents [65]. During the therapeutic process FLI is used in observation of the pathological tissue and find distribution and metabolism of drugs [66].…”

Section: Diagnosis and Imagingmentioning

confidence: 99%

A Review of the State of the Art towards Biological Applications of Graphene-based Nanomaterials

Sharma

Yusuf

Kumar

et al. 2021

JPRI

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The field of nanoscience has evolved into a wide variety of successes over the past two decades and the emphasis on nanotechnology is to revolve around various dynamic fields, such as sensor, biomedical, and many useful applications. Advances in related fields are certainly due to the ability to synthesize nanoparticles from a variety of materials, structures, and to convert samples into complex nanoarchitectures. The promises of nanomedicine are broad. Graphene (Gr), the first 2-dimensional material to stand alone, is a type of new nanomaterial that leads to the excitement of natural biological applications. Number of researches has been conducted on applicability of GBNs in the area of environment, biomedical, and healthcare sectors. As compared to other nanomaterials, extraordinary properties of graphene-based nanomaterials (GBNs) like high surface area, multilayers, multifunctional and excellent biocompatibility make them capable to play great roll of highly-tailored multifunctional delivery vehicles for drugs delivery, gene delivery, phototherapy and bioimaging. However, research communities performed plenty of research works on GBNs synthesis and biological acitivity evaluation, but there is limited comprehensive reviews published so far biological applications. So, we have studied a large number of scientific reports and investigations, presented in this review describing recent progress and modern perspectives with respect to graphene and related nanomaterials for biological applications.

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“…From the carbon family, graphene and its derivatives have been the most extensively studied nanomaterials due to their exceptional versatility in terms of physical, chemical, and biological behavior. Currently, graphene and its derivatives are widely investigated for biomedical applications such as drug delivery [33], tumor therapy [34], and theranostics [35,36]. In the area of biomedical applications, biocompatibility and biosafety represent key factors of the chosen materials.…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications

et al. 2022

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The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues and organs for repair or replacement. Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. This review critically focuses on opportunities to employ protein–graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. Herein, recent applications and the biological activity of nanocomposite bioconjugates are analyzed with respect to cell viability and proliferation, along with the ability of these constructs to sustain the formation of new and functional tissue. Novel strategies and approaches based on stem cell therapy, as well as the involvement of the extracellular matrix in the design of smart nanoplatforms, are discussed.

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Graphene-Based Magnetic Nanoparticles for Theranostics: An Overview for Their Potential in Clinical Application

Cited by 19 publications

References 78 publications

Influences of Dispersions’ Shapes and Processing in Magnetic Field on Thermal Conductibility of PDMS–Fe3O4 Composites

Influences of Dispersions’ Shapes and Processing in Magnetic Field on Thermal Conductibility of PDMS–Fe3O4 Composites

A Review of the State of the Art towards Biological Applications of Graphene-based Nanomaterials

Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications

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