Grape seed proanthocyanidins inhibit proliferation of pancreatic cancer cells by modulating microRNA expression

Zhan, Leilei; Guo, Dongqi; Xiang, Yanju; Tian, Muxing; Zhang, Yu; Wu, Hong; Wei, Yaxun; Ma, Ganglong; Han, Zhanjiang

doi:10.3892/ol.2019.9887

Cited by 8 publications

(13 citation statements)

References 30 publications

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“…In addition, GSPs reversed EMT process and inhibited cell migration [143]. In addition, GSPs demonstrated the ability to modulate miRNA expression and to act similar to chemotherapeutic agents [144,145].…”

Section: Grape Flavanolsmentioning

confidence: 99%

“…Green tea flavanolsChelation of iron (Fe) and copper (Cu) ions; Cell cycle arrest, apoptosis, inhibition of NO-synthase gene expression and NO-synthase enzyme activity, Akt inhibition, decrease of mutant p53 protein [130,[132][133][134]137]. Grape flavanols Reversed EMT process, cell migration inhibition; miRNA expression modulation, decreased NF-κB inactivation, cell proliferation inhibition, apoptosis [143][144][145][146]. Curcumin Antioxidant, anti-angiogenic and anti-inflammatory effects; Modulation fo NFkB, STAT-3, SP1, Notch-1, COX-II, ATM/Chk1, WT1 [157][158][159][160].…”

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confidence: 99%

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Polyphenols as Possible Agents for Pancreatic Diseases

Gašić

Ćirić

Pejcic³

et al. 2020

Antioxidants

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Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.

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Section: Grape Flavanolsmentioning

confidence: 99%

mentioning

confidence: 99%

Polyphenols as Possible Agents for Pancreatic Diseases

Gašić

Ćirić

Pejcic³

et al. 2020

Antioxidants

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“…Grape proanthocyanidins have been associated with a decrease of UVB-induced photocarcinogenesis in SKH-1 mice through the regulation of immunosuppression by decreasing the expression of IL-10 and increasing that of IL-12 ( Katiyar et al, 2017 ). Proanthocyanidins also inhibit cell proliferation by means of the modulation of miRNA expression ( Wang et al, 2019 ).…”

Section: Polyphenols: Their Chemistry and Their Importance In Human Healthmentioning

confidence: 99%

Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways

2021

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Polyphenols constitute an important group of natural products that are traditionally associated with a wide range of bioactivities. These are usually found in low concentrations in natural products and are now available in nutraceuticals or dietary supplements. A group of polyphenols that include apigenin, quercetin, curcumin, resveratrol, EGCG, and kaempferol have been shown to regulate signaling pathways that are central for cancer development, progression, and metastasis. Here, we describe novel mechanistic insights on the effect of this group of polyphenols on key elements of the signaling pathways impacting cancer. We describe the protein modifications induced by these polyphenols and their effect on the central elements of several signaling pathways including PI3K, Akt, mTOR, RAS, and MAPK and particularly those affecting the tumor suppressor p53 protein. Modifications of p53 induced by these polyphenols regulate p53 gene expression and protein levels and posttranslational modifications such as phosphorylation, acetylation, and ubiquitination that influence stability, subcellular location, activation of new transcriptional targets, and the role of p53 in response to DNA damage, apoptosis control, cell- cycle regulation, senescence, and cell fate. Thus, deep understanding of the effects that polyphenols have on these key players in cancer-driving signaling pathways will certainly lead to better designed targeted therapies, with less toxicity for cancer treatment. The scope of this review centers on the regulation of key elements of cancer signaling pathways by the most studied polyphenols and highlights the importance of a profound understanding of these regulations in order to improve cancer treatment and control with natural products.

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“…International Publisher proliferation, and cell cycle arrest [12][13][14]. In addition, miRNAs are also involved in the extensive process of tumorigenesis in various cancers, such as pancreatic cancer, brain glioma, cervical cancer and prostate cancer [15][16][17][18][19][20]. With the application of gene sequencing in tumors, miRNAs have been considered novel biomarkers in the prediction of prognosis and drug resistance [21][22][23][24][25], and integrating multiple miRNAs could be more effective and lead to a better prediction than single miRNAs [16,23,[26][27][28][29].…”

Section: Ivyspringmentioning

confidence: 99%

Fifteen-MiRNA-Based Signature Is a Reliable Prognosis-Predicting Tool for Prostate Cancer Patients

et al. 2021

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Recurrence is a major problem for prostate cancer patients, thus, identifying prognosis-related markers to evaluate clinical outcomes is essential. Here, we established a fifteen-miRNA-based recurrence-free survival (RFS) predicting signature based on the miRNA expression profile extracted from The Cancer Genome Atlas (TCGA) database by the LASSO Cox regression analysis. The median risk score generated by the signature in both the TCGA training and the external Memorial Sloan-Kettering Cancer Center (MSKCC) validation cohorts was employed and the patients were subclassified into low- and high-risk subgroups. The Kaplan-Meier plot and log-rank analyses showed significant survival differences between low- and high-risk subgroups of patients (TCGA, log-rank P < 0.001 & MSKCC, log-rank P = 0.045). In addition, the receiver operating characteristic curves of both the training and external validation cohorts indicated the good performance of our model. After predicting the downstream genes of these miRNAs, the miRNA-mRNA network was visualized by Cytoscape software. In addition, pathway analyses found that the differences between two groups were mainly enriched on tumor progression and drug resistance-related pathways. Multivariate analyses revealed that the miRNA signature is an independent indicator of RFS prognosis for prostate cancer patients with or without clinicopathological features. In summary, our novel fifteen-miRNA-based prediction signature is a reliable method to evaluate the prognosis of prostate cancer patients.

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Grape seed proanthocyanidins inhibit proliferation of pancreatic cancer cells by modulating microRNA expression

Cited by 8 publications

References 30 publications

Polyphenols as Possible Agents for Pancreatic Diseases

Polyphenols as Possible Agents for Pancreatic Diseases

Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways

Fifteen-MiRNA-Based Signature Is a Reliable Prognosis-Predicting Tool for Prostate Cancer Patients

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