Granuloma Formation in Herpes Zoster Scars

Abstract

An 82-year-old male with chronic lymphocytic leukaemia developed an erythematous papular eruption over the trunk. Lesions occurred at the site of scars related to a disseminated herpes zoster infection 3 months previously. Biopsy of a lesion showed granuloma formation. The rash resolved spontaneously over 6–8 weeks.

Sarcoid-Like Granulomas Secondary to Herpes simplex Virus Infection

“…Granuloma formation at the site of herpes zoster scars has been reported previously in a patient with sarcoidosis [3] and in two patients with chronic lymphocytic leukemia [4,5], To our knowledge, the appearance of granuloma tous lesions has not been found in the skin after HSV infec tions. There is a very close similarity between our patient and the cases secondary to herpes zoster.…”

“…In patients with immune altera tions that had presented infections by varicella-zoster virus, a secondary appearance of lesions restricted to the affected dermatome has been described, such as granuloma annu lare [l, 2], sarcoidal granuloma [3,4], tuberculoid granu loma [5], granulomatous vasculitis [6], pseudolymphoma [7], lymphoplasmocytoid lymphoma [8] and Kaposi's sar coma [9]. In some of these patients [6], the efforts to detect viral antigens using polymerase chain reactions have been negative.…”

Cutaneous T-cell lymphoma sparing resolving dermatomal herpes zoster lesions: an unusual phenomenon and implications for pathophysiology

“…1,3 In most patients, the paraproteinemia is of undetermined significance, but it has been associated with multiple myeloma in 10% of patients. 1,4 The treatment of scleromyxedema is frequently disappointing, and the evidence of therapeutic efficacy is largely anecdotal. 5 Although some treatments have focused on improving the appearance of skin lesions, other treatments have targeted the associated plasma cell dyscrasia.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12] We present a unique phenomenon in which an area of healed herpes zoster was spared by erythrodermic cutaneous T-cell lymphoma (CTCL). Further immunohistochemical analysis of this phenomenon suggests a role for Langerhans cells (LC) in the pathobiology of epidermotropism in CTCL.…”

Post-herpes Zoster Scar Sarcoidosis

“…Secondly, sarcoidosis may account for granuloma formation, but``sarcoidal'' granuloma formation in herpes zoster scars has also been reported in patients with chronic lymphocytic leukaemia (3).…”