Post-herpes Zoster Scar Sarcoidosis

Barrazza, Vincent

doi:10.1080/000155599750010148

Cited by 6 publications

(6 citation statements)

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“…Fôként az infekciós eredetû granulomak (tuberculosis, lepra, mycosisok) kizárása fontos (1, 7), valamint elkülönítendô a syphilis (1) és keloid (7) is. Megemlítendô a herpes zoster utáni keloid talaján kialakult sarcoidosis (27) lehetôsége. Az arcon megjelenô tünetek esetén a chronicus cutan lupus erythematosus (CCLE) (1) gyanúja is felmerülhet.…”

Section: áBraunclassified

“…Az arcon megjelenô tünetek esetén a chronicus cutan lupus erythematosus (CCLE) (1) gyanúja is felmerülhet. Elkülönítendôek a kontakt allergiás eredetû granulomatosus (27,41) elváltozások, a chroni-cus lichenoid reakciók (28), illetve malignus tumorok (29)(30)(31)(32)(33)(34)(35)(36)(37). Sarcoidosist utánzó malignus bôrelváltozások lehetnek például a B-sejtes lymphoma (29), pseudolymphoma (30), melanoma (31,32), basalioma (33), non-Hodgkin lymphoma (34) és laphám carcinoma (35).…”

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A case of sarcoidosis after cosmetics tattoo

Harsányi¹,

Preisz²,

Temesvári³

et al. 2015

BVSZ

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A szerzôk egy 34 éves nôbeteg esetét mutatják be, akinél egy éve diagnosztizálták a cutan sarcoidosist. Az elsô kozmetikai tetoválás 10 éve történt a szemöldökök vonalában. A második tetoválást más festékkel végezték. Tíz hónappal késôbb a jobb szemöldök területén barnásvörös, tömött nodulusok jelentek meg. Klinikai kép alapján felmerült a cutan sarcoidosis, melyet a szövettani vizsgálat igazolt. A beteg laboratóriumi vizsgálatai magas szérum angiotenzin-konvertázenzim szintet mutattak. A mellkasröntgen vizsgálat, majd az elvégzett komputer tomográfiás vizsgálat is mindkét tüdôlebenyben jól körülírt nodulusokat ábrázolt. A tuberculosist a kiegészítô vizsgálatok kizárták. A pulmonáris sarcoidosist a késôbbiekben elvégzett vizsgálatok nem tudták egyértelmûen alátámasztani. Az epicutan tesztelés negatív eredményt adott. Lokális kortikoszteroid terápia mellett a bôrtünetek kismértékben javultak. A szisztémás kortikoszteroid kezelésbe a beteg nem egyezett bele. A szerzôk az eset kapcsán összefoglalják a kozmetikai tetoválás következményeként leírt cutan sarcoidosissal kapcsolatos jelenlegi ismereteket, megfigyeléseket és új kezelési lehetôségeket.

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A case of sarcoidosis after cosmetics tattoo

Harsányi¹,

Preisz²,

Temesvári³

et al. 2015

BVSZ

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“…Pathogenesis of necrobiosis lipoidica has been debated. 2 Therapeutic effectiveness of intravenous immunoglobulin and biological agents for neutralization in tumor necrosis factor-alpha (TNF-a) has been described. 3,4 Wakusawa et al 5 described a case of type I diabetes-associated necrobiosis lipoidica with histopathological evidence of the significant number of Th17 cells.…”

Section: Necrobiosis Lipoidica With Infiltration Of Th17 Cells Into Vmentioning

confidence: 99%

“…Email: toyamade@fmu.ac.jp zoster scar sarcoidosis have been reported. [2][3][4] Healed skin following herpes zoster is not normal, and scar formation may induce sarcoidal granuloma. On the other hand, c-interferon induced by viral infection favors T-helper 1 shift, which may play a role in granuloma formation.…”

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confidence: 99%

Post‐herpes zoster sarcoidosis

Miyamae

Yamamoto

2014

The Journal of Dermatology

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Post-herpes zoster sarcoidosisDear Editor, Post-herpetic isotopic reactions induce various skin conditions on healed sites, and several possible mechanisms such as viral, immunological, vascular and neural etiology are proposed in this process. We herein report a case of sarcoidosis on the sites of herpes zoster.A 72-year-old man was suffering from diabetes mellitus, hypertension and hyperlipidemia. He developed herpes zoster on the trunk, and was treated with antiviral drugs (acyclovir 4000 mg/day for 7 days) in a nearby clinic. Three months later, asymptomatic eruptions appeared on the healed herpes zoster sites. He also complained of weight loss, night sweats and general fatigue. Physical examination revealed infiltrative erythematous papules on the left lower back, with distribution coinciding with herpes zoster-affected areas ( Fig. 1a). A biopsy specimen revealed non-necrotizing, epithelioid granulomas located in the mid-to lower dermis with minimal lymphocytic infiltration ( Fig. 1b). Detailed clinical examination revealed scar sarcoidosis on the knees, and additional biopsy also showed sarcoid granuloma in the dermis. Laboratory examination showed liver dysfunction, increased serum levels of angiotensin-converting enzyme (39.9 U/L; normal range, 7-25) and soluble interleukin-2R (4930 U/mL; normal, 124-460). However, antinuclear antibody was negative. Chest X ray revealed bilateral hilar lymphadenopathy, and computed tomography showed lymph node adenopathy in the lung and porta hepatis. No abnormalities were detected on cardiac or ophthalmological examination. Porta hepatic lymph node biopsy did not reveal lymphoma. Bone marrow biopsy showed granulomatous changes with multinucleated giant cells (Fig. 1c), however, lymphoma was not detected.We described a case in which cutaneous sarcoidosis developed on the herpes zoster-affected sites. Detailed investigation revealed scar sarcoidosis on the knees, and systemic investigation revealed lung sarcoidosis. Because our patient complained of persistent slight fever, weight loss, night sweats and multiple lymphadenopathy, bone marrow aspiration was carried out under suspicion of lymphoma (sarcoidlymphoma syndrome). The results showed no atypical cells, but granulomatous features were detected in the bone marrow, suggesting bone marrow involvement of sarcoidosis. Also, lymph node biopsy denied malignant lymphoma. Diagnosis of sarcoidosis was made on the occasion of cutaneous lesions following herpes zoster. Therefore, we conclude that our patient developed systemic sarcoidosis prior to the onset of herpes zoster, and cutaneous sarcoidosis was induced at the site of herpes zoster. Isotopic and isomorphic response sometimes overlap in multicentric systemic diseases, 1 which is true of our case. To date, several cases of post-herpes (a) (b) (c) Figure 1. (a) Clinical appearance showing brownish papules with zosteriform distribution. (b) Histological features showing sarcoid granuloma in the lower dermis. (c) Granuloma formation in the bone marrow (hematoxylin-eosin, or...

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“…It is localized in scars and marked by inflammatory infiltrations and livid discolorations [2]. Its occurrence is described after such conditions as herpes zoster infections [3,4], pseudofolliculitis barbae [5], hyposensitivities [6], operations, trauma [7,8], cosmetic tattoos, and traumatic tattoos [7]. In every instance, there is the spontaneous development of livid or reddish-brown plaques on scars that were previously atrophic for the most part; this phenomenon occurs at varying intervals.…”

Section: Introductionmentioning

confidence: 99%