Scar sarcoidosis—treatment with the Q‐switched ruby laser

Grema, Hortensia; Greve, Bärbel; Raulin, Christian

doi:10.1002/lsm.10059

Cited by 28 publications

(18 citation statements)

References 13 publications

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“…198 Case reports have described improvement or resolution of skin lesions, especially popular and nodular sarcoidosis, scar sarcoidosis, and lupus pernio, 199 with several lasers, including pulsed dye laser (PDL), [200][201][202] carbon dioxide (CO 2 ), 203,204 neodymium:yttrium aluminum garnet, 205 and Q-switched ruby lasers. 206 In one of these reports, significant improvement of lupus pernio recalcitrant to systemic steroids and steroid-sparing agents was achieved with PDL therapy followed by nonablative fractional resurfacing. 207 However, ulceration after PDL treatment 208 and induction of sarcoidal lesions after CO 2 laser ablation 209 have also been reported.…”

Section: Other Pharmacologic Agentsmentioning

confidence: 97%

Sarcoidosis

Sanchez

Haimovic

Prystowsky

2015

Dermatologic Clinics

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Sarcoidosis is a disease characterized by noncaseating granulomatous infiltration of 1 or more organs. In North America, after the lungs and thoracic lymph nodes, the skin is the next most commonly involved organ. Data from multiple studies indicate a coaction between genetic and environmental factors in immunologically susceptible hosts. The disease's many clinical manifestations and course vary greatly and are influenced by race, ethnicity, and gender. In the skin, the lesions of sarcoidosis are classified as specific when noncaseating granulomas are present, and nonspecific when there is an inflammatory reaction pattern devoid of granulomas.

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Section: Other Pharmacologic Agentsmentioning

confidence: 97%

Sarcoidosis

Sanchez

Haimovic

Prystowsky

2015

Dermatologic Clinics

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“…Certain lasers have also been reported to be helpful for cutaneous sarcoidosis, with pulsed dye, CO 2 for laryngeal lesions, ruby, and potassium titanyl phosphate lasers being reported. [136][137][138][139][140][141] In addition, surgical excision can be used on inactive skin lesions in certain circumstances. Because cutaneous sarcoidosis can have a predilection for areas of trauma or scars, lasers and surgical removal should be used with caution.…”

Section: Differential Diagnosismentioning

confidence: 99%

Cutaneous Sarcoidosis

Wanat

Rosenbach

2015

Clinics in Chest Medicine

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The skin is the second most common organ affected in sarcoidosis, which can affect patients of all ages and races, with African American women having the highest rates of sarcoidosis in the United States. The cutaneous manifestations are protean and can reflect involvement of sarcoidal granulomas within the lesion or represent reactive non-specific inflammation, as seen with erythema nodosum. Systemic work-up is necessary in any patient with cutaneous involvement of sarcoidal granulomas, and treatment depends on other organ involvement and severity of clinical disease. Skin-directed therapies are first line for mild disease, and immunomodulators or immunosuppressants may be necessary.

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“…Newer therapies that have been reported include topical tacrolimus, oral pentoxifylline, tetracyclines, isotretinoin, leflunomide, infliximab, and cyclosporine A18. Recently, some reports demonstrated that laser therapy, including a Q-switched ruby laser or pulsed dye laser, is effective in cutaneous sarcoidosis by debulking the granulomatous lesions, possibly by activation of immunologic processes (18,20). Photodynamic therapy is also reported to be effective in refractory cases (21).…”

Section: Discussionmentioning

confidence: 97%