Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco

Wojtukiewicz, Marek Z.; Sierko, Ewa; Skalij, Piotr; Kamińska, M; Zimnoch, L; Brekken, Ralf A.

doi:10.17219/acem/62398

Cited by 12 publications

(12 citation statements)

References 33 publications

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“…In terms of breast cancer, Wojtukiewicz et al . were able to demonstrate G‐CSFR positivity by IHC in 20/28 breast cancer tissue samples. Although present in 71% of samples examined, staining intensity was only classified as high in 21% of cases.…”

Section: G‐csf As An Alternative Prognostic Indicatormentioning

confidence: 93%

Neutrophils, G‐CSF and their contribution to breast cancer metastasis

2017

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Evidence is mounting for a role for neutrophils in breast cancer progression to metastasis. However, the role of G‐CSF in neutrophil biology in a cancer setting remains to be defined. Herein we discuss the most recent clinical and experimental evidence for neutrophils and G‐CSF in the promotion of metastasis, demonstrating a potential mechanistic link between them. Understanding this link is imperative both for the development of diagnostic tests and for therapies targeting neutrophils to improve the treatment of breast cancer patients with or at risk of developing metastatic disease. As a high neutrophil‐to‐lymphocyte ratio in patients predicts poor outcome, while mild neutropenia predicts an improved outcome, we urge caution in the use of G‐CSF in neutrophil recovery following chemotherapy as there is increasing evidence in preclinical models that G‐CSF can promote metastasis.

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Section: G‐csf As An Alternative Prognostic Indicatormentioning

confidence: 93%

Neutrophils, G‐CSF and their contribution to breast cancer metastasis

2017

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“…4,5 Previous studies have reported that increased mean VEGF serum concentration may be related to tissue hypoxia and inflammation during age-related macular degeneration, 6 rheumatoid diseases, 7 sepsis, 8 coronary heart disease, 9 chronic obstructive pulmonary disease (COPD), 10 and cancers. 11,12 For this reason, the peripheral VEGF levels have been considered as a biomarker of neovascularization and vascular remodeling. Hypoxia as well as inflammation are also relevant to asthma -therefore the biological properties of VEGF have led to interest of this molecule within the lung, suggesting that the higher expression of VEGF may play a potential role in the pathogenesis of asthma and lung remodeling.…”

Section: Introductionmentioning

confidence: 99%

VEGF serum concentration and irreversible bronchoconstriction in adult asthmatics

Gomułka¹,

Liebhart²,

Gładysz³

et al. 2019

Adv Clin Exp Med

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Background. Vascular endothelial growth factor (VEGF) is an angiogenic, heparin-binding glycoprotein playing an important role in the pathogenesis of many diseases and disorders, including asthma. It has been reported that increased VEGF serum concentration is a biomarker of neovascularization, which could suggest that higher VEGF expression may be relevant to asthmatics with airway remodeling and irreversible bronchoconstriction. Objectives. The aim of this study was to assess the possible association between VEGF serum concentration and irreversible bronchoconstriction in adult patients with a diagnosis of asthma. Material and methods. This study involved 82 adult patients with asthma (42 persons with and 40 persons without irreversible bronchoconstriction) and 40 healthy adult controls. Vascular endothelial growth factor serum concentration was analyzed using enzyme-linked immunosorbent assay (ELISA). Results. Vascular endothelial growth factor serum concentration in patients with asthma was higher than in healthy controls (p = 0.0131), particularly in those from the subgroup of irreversible bronchoconstriction (p = 0.0133). The rising tendency was confirmed using the Kruskal-Wallis rank sum test that showed a significant difference (p = 0.0374) in VEGF values among the 3 groups examined: healthy controls (Me = 246.6 pg/mL), asthmatics with reversible bronchoconstriction (Me = 288.6 pg/mL) and asthmatics with irreversible bronchoconstriction (Me = 340.6 pg/mL). However, the direct comparison between the 2 asthmatics groups (reversible vs irreversible bronchoconstriction) did not show a statistically significant difference (p = 0.5521). Conclusions. Increased VEGF serum concentration is characteristic of patients with asthma, especially those with irreversible bronchoconstriction.

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“…Through binding to VEGF receptor (VEGFR) on the endothelial cells, it increases the permeability of new blood vessels through para-crine mechanism and promotes the growth of new blood vessels in tumors. Furthermore, VEGF can promote tumor infiltration and metastasis through autocrine mechanism, which may be related to VEGF's regulation of matrix metalloproteinases (MMPs), tumor cytokines, and integrins [20,21]. Studies have found that the expression level of VEGF has a certain correlation with the prognosis of lung cancer, and its high expression can promote tumor infiltration and metastasis [22].…”

Section: Discussionmentioning

confidence: 99%

Effects of Laminaria Japonica Polysaccharides on the Survival of Non-Small-Cell Lung Cancer A549 Cells

Yao

Qian

Qin

2019

International Journal of Polymer Science

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Objective. To investigate the effect of Laminaria japonica polysaccharides (LJP) on the survival of non-small-cell lung cancer (NSCLC) A549 cells and its mechanism. Methods. In vitro: the cells were randomly divided into control group, LJP (5 mg/ml) group, LJP (10 mg/ml) group, and LJP (20 mg/ml) group. After corresponding treatment, the survival rate and the expression of proteins related to proliferation, apoptosis, epithelial-mesenchymal transition (EMT), and signaling pathway were detected by CCK8 assay and Western blot, respectively. In vivo: a xenograft model was established to detect the tumor volume and mass and the expression of the above pathway proteins. Results. Compared with the control group, LJP decreased the survival rate of A549 cells (P<0.05), inhibited the protein expression of Ki67 and PCNA (P<0.05), downregulated the expression of Bcl-2 while upregulated the expression of Bax, cl-caspase-3, and cl-caspase-9 (P<0.05), upregulated the expression of E-cadherin, downregulated the expression of vascular endothelial growth factor (VEGF) and N-cadherin (P<0.05), and downregulated β-catenin, transcription factor-4 (TCF4), and c-Myc protein expression levels (P<0.05). In vivo: LJP decreased the volume and mass of the xenograft tumors and downregulated β-catenin, TCF4, and c-Myc protein expression levels compared with the control group (P<0.05). Conclusion. LJP can inhibit the survival of non-small-cell lung cancer A549 cells in vitro, and its mechanism is related to the inhibition of activation of β-catenin/TCF4 pathway activation.

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Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco

Cited by 12 publications

References 33 publications

Neutrophils, G‐CSF and their contribution to breast cancer metastasis

Neutrophils, G‐CSF and their contribution to breast cancer metastasis

VEGF serum concentration and irreversible bronchoconstriction in adult asthmatics

Effects of Laminaria Japonica Polysaccharides on the Survival of Non-Small-Cell Lung Cancer A549 Cells

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