Granular cell tumour of the oesophagus mimicking a gastrointestinal stromal tumour on frozen section

Prematilleke, I.; Sujendran,; Warren, Bryan F.; Maynard, Nicholas; Piris, J

doi:10.1111/j.1365-2559.2004.01820.x

Cited by 8 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diagnosis of GCTs is usually not problematic. Rare GCTs with prominent spindling may mimic GIST [15,16], but more typical diagnostic areas are usually present. GCTs are negative for CD117, desmin, α-SMA, and h-caldesmon.…”

Section: Discussionmentioning

confidence: 97%

Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-associated gastric schwannoma and unusual morphologic variants

Agaimy

Märkl

Kitz³

et al. 2010

Virchows Arch

View full text Add to dashboard Cite

The frequency and morphological spectrum of gastrointestinal peripheral nerve sheath tumors (PNSTs) from consecutive case material has not been studied in the c-KIT era. We reviewed all mesenchymal gastrointestinal (GI) lesions at our departments according to current diagnostic criteria. PNSTs formed the third commonest group of mesenchymal GI tumors with a lower frequency (< or =5%) compared to gastrointestinal stromal tumors (GISTs; approximately 50%) and smooth muscle neoplasms ( approximately 30%). Granular cell tumors (GCTs; n = 31) and schwannomas (n = 22) were the most common types of PNSTs encountered. Rare tumors included neurofibromatosis 1 (NF1)-associated PNSTs (n = 5) and gastric perineurioma (n = 1). Thirteen schwannomas (including also some recent cases) were initially diagnosed as GIST, leiomyoma, or neurofibroma. Unusual histological variants included sigmoid GCT with prominent lipomatous component (n = 1), reticular-microcystic schwannoma of small (n = 1) and large (n = 1) bowel, NF1-associated gastric schwannoma (the first case to date), and psammomatous melanotic colonic schwannoma unrelated to Carney complex (n = 1). PNSTs coexisted with GIST in four patients (three had definite NF1). In conclusion, PNSTs of the GI tract are rare uniformly benign neoplasms that may show schwannian, perineurial, fibroblastic, or mixed differentiation. Most of them (92%) occurred sporadically unassociated with NF1 or NF2. Gastrointestinal PNSTs are still underrecognized by general pathologists. Awareness of their diverse morphology will help to avoid confusing them with smooth muscle neoplasms and GIST that they may closely mimic.

show abstract

Section: Discussionmentioning

confidence: 97%

Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-associated gastric schwannoma and unusual morphologic variants

Agaimy

Märkl

Kitz³

et al. 2010

Virchows Arch

View full text Add to dashboard Cite

show abstract

“…However, for malignant esophageal GCT, it is extremely difficult to differentiate it from esophageal squamous cancers. Besides, GCT can also mimic gastrointestinal stromal tumor (GIST) (20) or leiomyoma. In the present study, two of the five patients who underwent biopsy were misdiagnosed prior to resection; one was misdiagnosed as GIST and the other as leiomyoma.…”

Section: Discussionmentioning

confidence: 99%

Esophageal granular cell tumor: Clinical, endoscopic and histological features of 19 cases

2014

View full text Add to dashboard Cite

Esophageal granular cell tumors (GCTs) are rare and often misdiagnosed. To demonstrate their clinicopathological features, the present study reports 19 cases and reviews the literature. There were 11 female and eight male esophageal GCT patients with a median age of 42.0 years. All the tumors were solitary. The majority of patient indications for endoscopy (89.5%) were non-specific and endoscopic therapy was performed in 17 cases with a relapse in one case after a 12-month follow-up. The endoscopic appearance of esophageal GCT was variable and the majority of tumors (80.0%) were located in the middle and lower esophageal segments. The size of the tumors ranged from 0.4 to 2 cm in diameter and the surface was white-gray, pink or yellow. Nine patients underwent an endoscopic ultrasound exam, eight of which demonstrated hypoechoic echostructures with a smooth margin and intracavity growth features. One case was derived from the muscularis propria layer with an irregular margin and intra- and extra-cavity growth features. The histological features could mimic other tumors and immunohistochemical stains are usually positive for S-100, periodic acid-Schiff, neuron-specific enolase and nestin. Three cases indicated pleomorphism and Ki-67 was locally positive. Esophageal GCTs are rare and endoscopic ultrasound features are variable. Immunohistochemical staining may aid in the diagnosis.

show abstract

“…The sites of these GCTs treated using MMS have been the buttocks, 5 the penis, 6 the plantar aspect of the foot, 7 the heel, 8 and the toe 10 . Other cases have been reported in which frozen sections were used to aid in the diagnosis of GCTs, but most of those cases were of noncutaneous GCTs, and none of them involved MMS 19–36 …”

Section: Discussionmentioning

confidence: 99%

“…10 Other cases have been reported in which frozen sections were used to aid in the diagnosis of GCTs, but most of those cases were of noncutaneous GCTs, and none of them involved MMS. [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] Although a few cases of GCT with perineural involvement and a plexiform growth pattern have been described in the literature, none of them were treated with MMS. [37][38][39][40] In 1994, Lee and colleagues published a report of two cases of ''a previously undescribed variant of GCT with an interesting plexiform pattern.''…”

Section: Discussionmentioning

confidence: 99%

Mohs Surgical Excision of a Granular Cell Tumor with Plexiform Features on the Arm of a 7-Year-Old Child

Youssef

Hinshaw

Longley

et al. 2010

Dermatologic Surgery

View full text Add to dashboard Cite

show abstract

Granular cell tumour of the oesophagus mimicking a gastrointestinal stromal tumour on frozen section

Cited by 8 publications

References 5 publications

Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-associated gastric schwannoma and unusual morphologic variants

Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-associated gastric schwannoma and unusual morphologic variants

Esophageal granular cell tumor: Clinical, endoscopic and histological features of 19 cases

Mohs Surgical Excision of a Granular Cell Tumor with Plexiform Features on the Arm of a 7-Year-Old Child

Contact Info

Product

Resources

About