Mohs Surgical Excision of a Granular Cell Tumor with Plexiform Features on the Arm of a 7-Year-Old Child

Youssef, Sherry; Hinshaw, Molly; Longley, B. Jack; Snow, Stephen N.; Teng, Joyce

doi:10.1111/j.1524-4725.2010.01492.x

Cited by 8 publications

(5 citation statements)

References 38 publications

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“…These neoplasms have slow indolent growth typically 1–2 cm in diameter and may involve any anatomic location including a wide variety of sites such as peripheral soft tissue, trunk, head and neck with special predilection to tongue, and may even involve internal organs commonly esophagus. Most common sites being skin, tongue and oral cavity; in children the most common locations being oral mucosa and extremities [ 4 ]. Rare familial associations have been reported especially in Noonan and LEOPARD syndromes and 5–15% can be multiple [ 5–7 ].…”

Section: Discussionmentioning

confidence: 99%

Multiple cutaneous granular cell tumors involving the shoulder and foot in a child; a rare case report

Amir,

Sheikh

et al. 2024

Journal of Surgical Case Reports

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Granular cell tumors are rare soft tissue neoplasms derived from Schwann cells and are characterized by their infiltrative, non-encapsulated nests and sheets of polygonal cells with fine eosinophilic cytoplasmic granules on histology. Herin, we report a case of a 10-year-old Saudi female who presented to the hospital with multiple asymptomatic skin lesions, the largest located on the right shoulder and left foot. Preoperative workup revealed the absence of liver metastasis, and the patient underwent complete surgical excision successfully. Histopathology revealed ill-defined proliferation of large bland cells with prominent eosinophilic granular cytoplasm and mild epithelial hyperplasia consistent with granular cell tumors. Granular cell tumors are a rare entity that represent only 0.5% of all soft tissue tumors. They have characteristic histological features and can present with both malignant and being features. Due to the rarity of this disease, further research is needed to enhance our understanding and improve recognition in future practice.

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Section: Discussionmentioning

confidence: 99%

Multiple cutaneous granular cell tumors involving the shoulder and foot in a child; a rare case report

Amir,

Sheikh

et al. 2024

Journal of Surgical Case Reports

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“…Mohs surgery may be an effective tool in managing deeply invasive GCTs or tumors that occur in functionally or cosmetically sensitive areas, such as over joint spaces . Mohs surgery was performed in two of the reported pediatric cutaneous GCT cases.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Granular Cell Tumors in Children: Case Series and Review of the Literature

Olayiwola

Hook

Miller

et al. 2017

Pediatric Dermatology

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Granular cell tumors (GCTs) are uncommon benign neoplasms thought to originate from Schwann cells. They most commonly present in adults as papules or nodules on mucosal sites. The clinical spectrum of GCT in children is not well delineated, although mucosal and cutaneous presentations have been reported. We present three children with cutaneous GCTs and review the literature in an attempt to further characterize this rare pediatric neoplasm.

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“…This case supported the use of MMS to preserve maximal tissue and functional movement of the limb. Follow‐up at 2 years showed no recurrence …”

Section: Introductionmentioning

confidence: 97%

“…Granular cell tumors (GCT) are tumors of neural and Schwann cell origin . They most commonly occur on the head and neck, particularly the tongue and oral cavity . Not all cases of GCT require treatment with MMS.…”

Section: Introductionmentioning

confidence: 99%

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Mohs micrographic surgery for cutaneous malignancies: A focus review of its indications in pediatric age groups

Kamal

Khachemoune

2018

Pediatric Dermatology

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Mohs micrographic surgery (MMS) is a highly specialized technique that has been successful in the treatment of a variety of skin tumors. The technique can be performed as an outpatient procedure and encompasses surgical excision and intraoperative assessment of tumor margins in one setting by the same physician. The process ensures precise margin control with maximal preservation of healthy tissues. Mohs micrographic surgery has been practiced worldwide, including in the United States, Europe (United Kingdom, Germany, Spain, Netherlands, Switzerland), and Australia. Although it is commonly performed in adults with greater success, it has been discussed less frequently in children. In this article, we describe several cutaneous tumors in children and the role of Mohs micrographic surgery in their management. A PubMed search was conducted to review the most common cutaneous tumors in children treated using Mohs micrographic surgery. In this review, we discuss indications for Mohs micrographic surgery and pertinent studies examining success rates in children. Mohs micrographic surgery has been used to treat several tumors in children and offers the advantage of high cure rates and tissue conservation. This report emphasizes the benefits of Mohs micrographic surgery in children and highlights several cutaneous tumors for which it has been used to treat successfully.

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Mohs Surgical Excision of a Granular Cell Tumor with Plexiform Features on the Arm of a 7-Year-Old Child

Abstract: The authors have indicated no significant interest with commercial supporters.

Cited by 8 publications

References 38 publications

Multiple cutaneous granular cell tumors involving the shoulder and foot in a child; a rare case report

Multiple cutaneous granular cell tumors involving the shoulder and foot in a child; a rare case report

Cutaneous Granular Cell Tumors in Children: Case Series and Review of the Literature

Mohs micrographic surgery for cutaneous malignancies: A focus review of its indications in pediatric age groups

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