Esophageal granular cell tumor: Clinical, endoscopic and histological features of 19 cases

Abstract

Esophageal granular cell tumors (GCTs) are rare and often misdiagnosed. To demonstrate their clinicopathological features, the present study reports 19 cases and reviews the literature. There were 11 female and eight male esophageal GCT patients with a median age of 42.0 years. All the tumors were solitary. The majority of patient indications for endoscopy (89.5%) were non-specific and endoscopic therapy was performed in 17 cases with a relapse in one case after a 12-month follow-up. The endoscopic appearance of esophageal GCT was variable and the majority of tumors (80.0%) were located in the middle and lower esophageal segments. The size of the tumors ranged from 0.4 to 2 cm in diameter and the surface was white-gray, pink or yellow. Nine patients underwent an endoscopic ultrasound exam, eight of which demonstrated hypoechoic echostructures with a smooth margin and intracavity growth features. One case was derived from the muscularis propria layer with an irregular margin and intra- and extra-cavity growth features. The histological features could mimic other tumors and immunohistochemical stains are usually positive for S-100, periodic acid-Schiff, neuron-specific enolase and nestin. Three cases indicated pleomorphism and Ki-67 was locally positive. Esophageal GCTs are rare and endoscopic ultrasound features are variable. Immunohistochemical staining may aid in the diagnosis.

Lack of Utility of Cytokeratins in Differentiating Pseudocarcinomatous Hyperplasia of Granular Cell Tumors from Oral Squamous Cell Carcinoma

“…It can occur in almost any part of the human body such as the oral cavity, breast, large intestine and stomach (Lack, et al ,1980;Patti et al, 2006;Huyskens and Geniets 2014;Zhang et al, 2014). For both GCT and oral squamous cell carcinoma (OSCC), the most common growth site in the oral cavity is the tongue (Neville, 2009).…”

Esophageal granular cell tumor: evaluation of pathological and clinical findings in series of 7 cases

“…On mm.den büyük çapta olan tümörlerde en sık bildirilen yakınma disfajidir (4,6) . Serimizde tüm olgularda tümör çapı 1 cm veya altındadır.…”

“…GCT olgularının büyük kısmı mukoza ya da submukozadan köken alsa da az sayıda tümörün muskularis propriadan kaynaklandığı bildirilmiştir (2,4,8) .…”

“…Tüm GCT'lerin %8'inin Gastrointestinal Sistem (GIS)'de yerleşim gösterdiği, bunların %2'sinin de özofagusta görüldüğü bildirilmektedir (1) . Genelde olgu sunumları veya küçük olgu serileri olarak İngi-lizce literatürde yer alan özofageal GCT'ler sayıca 400'den biraz fazladır (2)(3)(4) . Multipl olabilirler.…”

Granular Cell Tumour – Esophagus Presented As Gastric Esophgeal Reflex Disease

“…It is uncommon and benign in nature 2 . Though skin and soft tissues are commonly involved the tumor may also occur in almost all over the body 2 .…”