Granular Cell Tumour of the Perianal Region: which Therapeutic Attitude

Perianal Granular Cell Tumor: Report of a Case and Review of the Literature

“…Due to its low incidence, the literature on GCT consists mainly of single reports; Johnston and Helwig reported the largest series of gastrointestinal GCTs (74 cases) in 1981 4,17 . GCTs of the anal and perianal region are extremely rare, and only 25 cases have been described so far [4][5][6][7][8][9][10][11][12][13][14][15][16][17] , including some malignancies 10,15 . GCTs are often small and painless and may be clinically mistaken for a quiescent abscess or an early neoplasm.…”

“…A malignant GCT may histologically seem identical to a benign GCT and only the appearance of metastases (generally after local recurrence) will lead to a subsequent diagnosis of malignancy. In fact, 31 tumors that were thought to be benign and were treated by local excision ended up being malignant, with the occurrence of metastases in the long-term follow-up 15 . It is not clear if malignant lesions result from the transformation of benign lesions or start out as malignant.…”

Malignant granular cell tumor of the anal-perianal region and suprarenal hyperplasia: A casual association?

“…Bouraoui et al . [5] and Mnasri and Bouchoucha[6] were the first to describe a case of malignant GCT of the anal region. Other than these two reports, we have not found any other reports on occurrence of this type of malignancy in anal region.…”