Malignant granular cell tumor of the anal-perianal region and suprarenal hyperplasia: A casual association?

Francesco, Vincenzo De; Avellini, Claudio; Pappalardo, Salvatore; Proscia, Davide; Piccirillo, Fabio

doi:10.4103/0019-5154.74573

Cited by 6 publications

(9 citation statements)

References 3 publications

(3 reference statements)

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“…The eosinophilic granular cytoplasm is acidophilic, periodic acid–Schiff (PAS) positive and diastase-resistant [10]. Ultrastructural analysis demonstrates that the cytoplasmatic granules are an accumulation of lysosomes similar to those found in Schwann cells [2, 5, 8, 9]. Immunohistochemical diagnosis is made by the S100, NSE, Vimentin and lysosomal marker CD68 positivity that GCT demonstrates in its nucleus and cytoplasm, in line with GCT’s proposed Schwann cell origin [4, 5, 7].…”

Section: Discussionmentioning

confidence: 99%

“…Ultrastructural analysis demonstrates that the cytoplasmatic granules are an accumulation of lysosomes similar to those found in Schwann cells [2, 5, 8, 9]. Immunohistochemical diagnosis is made by the S100, NSE, Vimentin and lysosomal marker CD68 positivity that GCT demonstrates in its nucleus and cytoplasm, in line with GCT’s proposed Schwann cell origin [4, 5, 7]. Wan et al proposed that malignancy can be determined by a p53 greater than 50% and a Ki67 index greater than 10% [3].…”

Section: Discussionmentioning

confidence: 99%

“…About 8% of GCT lesions are localized to the gastrointestinal tract and the esophagus accounts for the majority of these cases followed by the large intestine [ 3 , 4 ]. There are less than 30 cases of perianal GCT reported in the literature, as of 2015, making it a rare anal neoplasm [ 2 , 3 , 5 ]. Most of the reported cases are single case reports; however, the US Armed Forces Institute of Pathology, Johnston et al , reported 75 cases of gastrointestinal GCT, of which 16 cases were localized to the perianal region [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Then, in 1935, Feyrter et al proposed the most current and accepted pathogenesis that the tumor as neural in origin dubbing GCT as a myoblastoma [ 1 ]. Gullino et al , in 1949, using immunohistochemistry and electron microscopy, described the myoblastoma as Schwann cell in origin due to its S100, neuron-specific enolase (NSE) and myelin-associated glycoprotein positive staining pattern [ 1 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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A rare case of perianal granular cell tumor: case report and literature review

Kelly

Stein

Charlene

et al. 2017

Journal of Surgical Case Reports

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Granular cell tumor (GCT) is a rare submucosal neoplasm most commonly localized in the oral mucosa; with one-third of all cases found in the tongue, with less than 30 cases of perianal GCT reported in the literature, making it a rare anal neoplasm. Wide local excision is the gold standard of treatment and follow-up includes annual colonoscopy due to the high incidence of reoccurrence. Here we describe a rare case of benign perianal GCT in a 29-year-old female who presented asymptomatically; however, pathology report revealed a S100 positive immunostaining pattern. GCT is an important differential to be included when evaluating a patient with an asymptomatic perianal submucosal lesion. Since GCT and Squamous Cell Carcinoma present with similar pseudoepitheliomatous hyperplasia of the epithelium it is important that a biopsy and immunohistochemical analysis be performed to allow for accurate diagnosis and appropriate treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A rare case of perianal granular cell tumor: case report and literature review

Kelly

Stein

Charlene

et al. 2017

Journal of Surgical Case Reports

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“…The most common clinical presentation is the presence of an asymptomatic mass found incidentally during the evaluation of perianal disorders such as hemorrhoids and fissures [ 6 ]. Patients may present with anal pain, discomfort, and bleeding [ 57 , 58 ]. The tumor can also be found as a polypoid mass in the anus [ 59 ].…”

Section: Gastrointestinal Gcts By Locationmentioning

confidence: 99%

Gastrointestinal and biliary granular cell tumor: diagnosis and management

Barakat

Kar

Pourshahid

et al. 2018

aog

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Granular cell tumors (GCTs) are generally thought to be of Schwann cell origin and are typically S-100 positive. Up to 11% of these tumors affect the gastrointestinal tract, most commonly the esophagus, colon, and stomach. While GCTs are mostly benign, malignant and metastatic GCTs have been reported. GCTs are usually found incidentally during esophagogastroduodenoscopy, colonoscopy, imaging studies or during the evaluation of non-specific symptoms. Endoscopically, they are typically yellow in appearance with intact mucosa. On endoscopic ultrasound, they usually are hypoechoic, homogenous, smooth-edged lesions that appear to originate from the submucosal layer, although other endoscopic and ultrasound appearances have been described. There is no consensus on how to treat GCT. Surgical and conservative approaches have been described in the literature. GCTs can also affect the biliary tract, where patients may be misdiagnosed with cholangiocarcinoma. We explore the epidemiology, histology, clinical presentation, diagnosis and treatment of these tumors in the gastrointestinal tract, including the pharynx, esophagus, stomach, small intestine, large intestine and the perianal region. In addition, GCTs in the biliary tract are reviewed.

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Malignant granular cell tumor of the median nerve: a case report with a literature review of 157 cases

et al. 2018

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Malignant granular cell tumors are an extremely rare, high-grade sarcoma with a schwannian phenotype and are composed of malignant granular cells with cytoplasmic lysosomal inclusion. To date, 157 cases of malignant granular cell tumors have been reported. We report the first case of a malignant granular cell tumor arising from the digital nerve to the median nerve in the palm, and we review the 157 previously reported cases and summarize the clinical profile, treatment, and outcome of this tumor. The median age, tumor size, and follow-up periods were 51 years, 6 cm, and 24 months respectively. With respect to the oncological result, 53 patients (33.8%) had no evidence for disease, 31 (19.7%) were alive with the disease, and 51 (32.5%) died because of the disease. Our case report indicates that rare malignant tumors can arise from the digital nerve to the median nerve in the palm, an anatomical site that is usually affected by benign lesions. Exhaustive discussions between surgeons and pathologists are necessary for the treatment of this rare malignant tumor.

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Malignant granular cell tumor of the anal-perianal region and suprarenal hyperplasia: A casual association?

Cited by 6 publications

References 3 publications

A rare case of perianal granular cell tumor: case report and literature review

A rare case of perianal granular cell tumor: case report and literature review

Gastrointestinal and biliary granular cell tumor: diagnosis and management

Malignant granular cell tumor of the median nerve: a case report with a literature review of 157 cases

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