A rare case of perianal granular cell tumor: case report and literature review

Abstract

Granular cell tumor (GCT) is a rare submucosal neoplasm most commonly localized in the oral mucosa; with one-third of all cases found in the tongue, with less than 30 cases of perianal GCT reported in the literature, making it a rare anal neoplasm. Wide local excision is the gold standard of treatment and follow-up includes annual colonoscopy due to the high incidence of reoccurrence. Here we describe a rare case of benign perianal GCT in a 29-year-old female who presented asymptomatically; however, pathology report revealed a S100 positive immunostaining pattern. GCT is an important differential to be included when evaluating a patient with an asymptomatic perianal submucosal lesion. Since GCT and Squamous Cell Carcinoma present with similar pseudoepitheliomatous hyperplasia of the epithelium it is important that a biopsy and immunohistochemical analysis be performed to allow for accurate diagnosis and appropriate treatment.

O Processo De Trabalho Em Saúde E a Educação Permanente: Desafios E Possibilidades

“…Desde então, diversos nomes vêm sendo utilizados para descrevê-la, tais como tumor de Abrikossoff, neurofibroma de células granulares e shwannoma de células granulares (SOARES et al, 2008). A lesão pode surgir em qualquer parte do corpo, sendo mais comumente encontrado na mucosa oral, pele, mama, tecido subcutâneo, trato gastrointestinal, trato biliar, trato respiratório, genital, órbita e processo mastóide (KELLY et al, 2017).…”

A rare case of perianal granular cell tumour in a 75-year-old female

“…Granular cell tumours (GCTs) are a rare type of soft tissue tumour that can be found in various anatomical locations. [1][2][3] Its occurrence in the perianal region is particularly infrequent with less than 30 cases reported in the literature since it was first described by a pathologist, Abrikossoff, in 1926. 2,3 GCT typically presents as a firm, painless mass.…”

“…[1][2][3] Its occurrence in the perianal region is particularly infrequent with less than 30 cases reported in the literature since it was first described by a pathologist, Abrikossoff, in 1926. 2,3 GCT typically presents as a firm, painless mass. 1,[3][4][5] As a result, when located perianally, it can lead to clinical uncertainty and potential incorrect identification as haemorrhoids, skin tags or abscess.…”

“…2,3 GCT typically presents as a firm, painless mass. 1,[3][4][5] As a result, when located perianally, it can lead to clinical uncertainty and potential incorrect identification as haemorrhoids, skin tags or abscess. Surgical excision is required for accurate diagnosis and adequate treatment of GCTs.…”

Tumor de células granulares em língua: relato de caso/Granular cell tumor in tongue: case report

“…Desde então, diversos nomes vêm sendo utilizados para descreve-la, tais como tumor de Abrikossoff, neurofibroma de células granulares e shwannoma de células granulares (SOARES et al, 2008). A lesão pode surgir em qualquer parte do corpo, sendo mais comumente encontrado na mucosa oral, pele, mama, tecido subcutâneo, trato gastrointestinal, trato biliar, trato respiratório, genital, órbita e processo mastóide (KELLY et al,2017).…”