Perianal Granular Cell Tumor: Report of a Case and Review of the Literature

Mistrangelo, Massimiliano; Cassoni, Paola; Scozzari, Gitana; Castellano, Isabella; Gavello, G.; Corno, F; Morino, Mario

doi:10.1177/030089160909500424

Cited by 10 publications

(25 citation statements)

References 16 publications

(18 reference statements)

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“…Other sites include the skin, gastrointestinal tract, breast, biliary tract, respiratory tract, genital tract, orbit and mastoid. About 8% of GCT lesions are localized to the gastrointestinal tract and the esophagus accounts for the majority of these cases followed by the large intestine [3, 4]. There are less than 30 cases of perianal GCT reported in the literature, as of 2015, making it a rare anal neoplasm [2, 3, 5].…”

Section: Introductionmentioning

confidence: 99%

“…About 8% of GCT lesions are localized to the gastrointestinal tract and the esophagus accounts for the majority of these cases followed by the large intestine [3, 4]. There are less than 30 cases of perianal GCT reported in the literature, as of 2015, making it a rare anal neoplasm [2, 3, 5]. Most of the reported cases are single case reports; however, the US Armed Forces Institute of Pathology, Johnston et al , reported 75 cases of gastrointestinal GCT, of which 16 cases were localized to the perianal region [2].…”

Section: Introductionmentioning

confidence: 99%

“…Most of the reported cases are single case reports; however, the US Armed Forces Institute of Pathology, Johnston et al , reported 75 cases of gastrointestinal GCT, of which 16 cases were localized to the perianal region [2]. GCT is classified as rare submucosa tumor with over 20 proposed histogenetic theories [3]. In 1926, Abrikossoff reported the first five cases of GCT with three of five being localized to the tongue.…”

Section: Introductionmentioning

confidence: 99%

“…About 1–2% of cases are malignant. Although the majority of cases are asymptomatic, Johnston et al reported that perianal GCT is more likely to present with perianal discomfort and hematochezia than other sites [3, 9]. Females have a 1.5:1 greater prevalence than males and presents between the fourth and sixth decade of life with an equal prevalence among all races [2, 4, 6, 10].…”

Section: Introductionmentioning

confidence: 99%

“…Benign lesions are often less than 3 cm and have uniform nuclei with the absence of mitotic figures, whereas, a lesions greater than 4 cm were found in 60% of malignant cases [4, 8]. Histological findings in benign and malignant lesions are identical; however, malignant cells can rarely demonstrate cellular necrosis, pleomorphism, enlarged nucleoli, cell elongation, increased nuclear-to-cytoplasmic ratio and mitotic activity [3, 6, 9]. Fanburg-Smith et al postulated the presence of three or more of these factors that indicate likely metastasis [4].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A rare case of perianal granular cell tumor: case report and literature review

Kelly

Stein

Charlene

et al. 2017

Journal of Surgical Case Reports

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Granular cell tumor (GCT) is a rare submucosal neoplasm most commonly localized in the oral mucosa; with one-third of all cases found in the tongue, with less than 30 cases of perianal GCT reported in the literature, making it a rare anal neoplasm. Wide local excision is the gold standard of treatment and follow-up includes annual colonoscopy due to the high incidence of reoccurrence. Here we describe a rare case of benign perianal GCT in a 29-year-old female who presented asymptomatically; however, pathology report revealed a S100 positive immunostaining pattern. GCT is an important differential to be included when evaluating a patient with an asymptomatic perianal submucosal lesion. Since GCT and Squamous Cell Carcinoma present with similar pseudoepitheliomatous hyperplasia of the epithelium it is important that a biopsy and immunohistochemical analysis be performed to allow for accurate diagnosis and appropriate treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A rare case of perianal granular cell tumor: case report and literature review

Kelly

Stein

Charlene

et al. 2017

Journal of Surgical Case Reports

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Connective tissue tumors

Calonje¹,

Brenn²,

Lazar³

2012

McKee's Pathology of the Skin

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Granular Cell Tumor of the Anal Canal: Case Report and Literature Review

Prats,

P.,

et al. 2024

Journal of Coloproctology

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Granular cell tumors (GCTs) are rare benign neoplasms that can occur anywhere in the body but are most commonly found in the head and neck region. These tumors are often asymptomatic and are incidentally discovered during routine rectal examination. In some cases, symptoms may include bleeding, pain, and a palpable mass. Imaging studies such as colonoscopy, ultrasound, magnetic resonance imaging (MRI), or computed tomography can be used to characterize and measure the tumor. Treatment typically involves local resection, with or without adjuvant radiotherapy, depending on the size, location, and pathological characteristics of the tumor. The prognosis for GCTs of the anal canal is generally good, with few cases of recurrence or metastasis reported, but long-term follow-up is recommended due to the potential for late recurrence or malignant transformation. The present study reports a 39-year-old female patient who presented with anal itching associated with protrusion of a perianal mass and who underwent treatment between November 2022 and December 2023. The MRI scan revealed a nodular image in its caudal aspect with involvement of the internal sphincter between 12 and 5 o'clock, which was successfully resected. Histopathology was compatible with GCT, and the patient had a satisfactory recovery and was discharged. In conclusion, GCTs of the anal canal are rare and extremely unusual tumors that can be difficult to diagnose and manage, requiring a multidisciplinary approach for optimal management.

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Perianal Granular Cell Tumor: Report of a Case and Review of the Literature

Cited by 10 publications

References 16 publications

A rare case of perianal granular cell tumor: case report and literature review

A rare case of perianal granular cell tumor: case report and literature review

Connective tissue tumors

Granular Cell Tumor of the Anal Canal: Case Report and Literature Review

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