Gram-negative bacterial endocarditis in adults: state-of-the-heart

Raza, Sania S.; Sultan, Omer W; Sohail, M. Rizwan

doi:10.1586/eri.10.76

Cited by 40 publications

(47 citation statements)

References 25 publications

(31 reference statements)

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“…With regard to microbiological and infection-related parameters, in our bivariate analysis, partly in accordance with the study by Hasbun and coworkers [4], an etiological agent different from Streptococcus and Staphylococcus was associated with higher mortality: this is also plausible according to clinical experience and published literature [18]. However, this factor did not emerge as an independent determinant in logistic regression.…”

Section: Discussionsupporting

confidence: 89%

The Need for a Specific Risk Prediction System in Native Valve Infective Endocarditis Surgery

Feo

Cotrufo²,

Carozza³

et al. 2012

The Scientific World Journal

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The need for a specific risk score system for infective endocarditis (IE) surgery has been previously claimed. In a single-center pilot study, preliminary to future multicentric development and validation, bivariate and multivariate (logistic regression) analysis of early postoperative mortality predictors in 440 native valve IE patients were performed. Mathematical procedures assigned scores to the independent predictors emerged (AUC of the ROC curve: 0.88). Overall mortality was 9.1%. Six predictors were identified and assigned scores, including age (5–13 points), renal failure (5), NYHA class IV (9), critical preoperative state (11), lack of preoperative attainment of blood culture negativity (5), perivalvular involvement (5). Four risk classes were drawn ranging from “very low risk” (≤5 points, mean predicted mortality 1%), and to “very high risk” (≥20 points, 43% mortality). IE-specific risk stratification models are both needed, as disease-specific factors (e.g., cultures, abscess), beside the generic ones (e.g., age, renal impairment) affect mortality, and feasible.

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Section: Discussionsupporting

confidence: 89%

The Need for a Specific Risk Prediction System in Native Valve Infective Endocarditis Surgery

Feo

Cotrufo²,

Carozza³

et al. 2012

The Scientific World Journal

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“…Subsequently, an increasing incidence of IE due to GNB and a changing pattern of risk factors were described among patients with health care contacts (4,5). Most of the knowledge about this clinical entity derived from some case series, single-center experiences, and the ICE study, including 49 patients with IE due to non-HACEK GNB (1,4,(13)(14)(15)(16)(17). Thus, our investigation represents the largest contemporary cohort of patients with IE due to non-HACEK GNB for which data have been collected to date.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Outcomes of Endocarditis Due to Non-HACEK Gram-Negative Bacilli: Data from the Prospective Multicenter Italian Endocarditis Study Cohort

Falcone

Tiseo

Durante‐Mangoni

et al. 2018

Antimicrob Agents Chemother

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The objective of this study was to investigate predisposing factors and outcomes of infective endocarditis (IE) caused by non-HACEK Gram-negative bacilli (GNB) in a contemporary multicenter cohort. Patients with IE due to GNB, prospectively observed in 26 Italian centers from 2004 to 2011, were analyzed. Using a case-control design, each case was compared to three age- and sex-matched controls with IE due to other etiologies. Logistic regression was performed to identify risk factors for IE due to GNB. Factors associated with early and late mortality were assessed by Cox regression analysis. The study group comprised 58 patients with IE due to GNB. We found that was the most common pathogen, followed by and The genitourinary tract as a source of infection (odds ratio [OR], 13.59; 95% confidence interval [CI], 4.63 to 39.93; < 0.001), immunosuppression (OR, 5.16; 95% CI, 1.60 to 16.24; = 0.006), and the presence of a cardiac implantable electronic device (CIED) (OR, 3.57; 95% CI, 1.55 to 8.20; = 0.003) were factors independently associated with IE due to GNB. In-hospital mortality was 13.8%, and mortality rose to 30.6% at 1 year. A multidrug-resistant (MDR) etiology was associated with in-hospital mortality (hazard ratio [HR], 21.849; 95% CI, 2.672 to 178.683; = 0.004) and 1-year mortality (HR, 4.408; 95% CI, 1.581 to 12.287; = 0.005). We conclude that the presence of a genitourinary focus, immunosuppressive therapy, and an indwelling CIED are factors associated with IE due to GNB. MDR etiology is the major determinant of in-hospital and long-term mortality.

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“…2 Gram-negative bacteria rarely infect native heart valves owing to less adherent potential to the endocardium in contrast to higher virulence organisms such as Staphylococci . 4 …”

Section: Discussionmentioning

confidence: 99%

Klebsiella oxytoca Endocarditis With Complete Heart Block

Ullah

Elbita

Abdelghany

et al. 2016

Journal of Investigative Medicine High Impact Case Reports

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Gram-negative bacterial endocarditis causes 5% of all bacterial endocarditis. Among gram-negative bacteria, Klebsiella species are rare causes of native valve endocarditis. Klebsiella oxytoca is an extremely rare subspecies that can infrequently cause endocarditis and is associated with poor outcome. We report a case of Klebsiella oxytoca endocarditis in an elderly man who initially presented with stroke but later developed sepsis and heart block secondary to endocarditis.

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Gram-negative bacterial endocarditis in adults: state-of-the-heart

Cited by 40 publications

References 25 publications

The Need for a Specific Risk Prediction System in Native Valve Infective Endocarditis Surgery

The Need for a Specific Risk Prediction System in Native Valve Infective Endocarditis Surgery

Risk Factors and Outcomes of Endocarditis Due to Non-HACEK Gram-Negative Bacilli: Data from the Prospective Multicenter Italian Endocarditis Study Cohort

Klebsiella oxytoca Endocarditis With Complete Heart Block

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