Klebsiella oxytoca Endocarditis With Complete Heart Block

Abstract

Gram-negative bacterial endocarditis causes 5% of all bacterial endocarditis. Among gram-negative bacteria, Klebsiella species are rare causes of native valve endocarditis. Klebsiella oxytoca is an extremely rare subspecies that can infrequently cause endocarditis and is associated with poor outcome. We report a case of Klebsiella oxytoca endocarditis in an elderly man who initially presented with stroke but later developed sepsis and heart block secondary to endocarditis.

Significant PR Prolongation and New Onset Left Bundle Branch Block in Aortic Root Abscess: A Marker of Disease Progression and Poor Prognosis

“…Finally, the conduction bundle divides into left and right bundle branches [6,7]. Given this close anatomic relation the conduction abnormalities, such as complete heart block and bundle branch blocks have been commonly reported as the complications of periannular infection [8][9][10][11][12][13] (Figure 7 and Figure 8). However, to the best of our knowledge, cases of isolated PR prolongation in aortic root abscess is sparsely reported [14].…”

Characterization and formulation into solid dosage forms of a novel bacteriophage lytic against Klebsiella oxytoca

“…oxytoca . While these gut pathologies are reversible and symptoms subside following cessation of antibiotic therapy [ 4 , 6 , 12 ], there is significant impact on the patient quality of life during this period [ 4 , 12 ], and this is potentially exacerbated with antibiotic regimes that continue for extended periods of time. Further, the cost to the patient of products to modulate the intestinal flora during antibiotic therapy, such as probiotics, is significant, while procedures such as faecal microbiota transplantation are invasive and as yet in their infancy.…”

“…The genus Klebsiella represents a group of organisms which despite contributing to the normal flora, are capable of causing serious disease in man. While people may carry these organisms in their gastrointestinal and upper respiratory tract without any symptoms, these bacteria have the capacity to invade and establish infections in these as well as a range of other tissues, including the lower respiratory tract, urinary tract, liver, central nervous system, circulation, cardiac tissue, dental tissue, and wounds [ 1 – 6 ]. The Klebsiella species most commonly associated with human disease are Klebsiella pneumoniae and Klebsiella oxytoca [ 7 ].…”

A case of Klebsiella oxytoca endocarditis in an intravenous drug user

“…Klebsiella oxytoca endocarditis, specifically, has been associated on several occasions with genitourinary or gastrointestinal pathology [3], [4], [8]. IV drug use is uncommonly associated with non-HACEK Gram-negative endocarditis and was found in only 4% of cases [1].…”

“…Klebsiella species are responsible for prosthetic valve endocarditis more frequently than for native valve endocarditis, and involve the aortic valve in nearly two-thirds of cases [2] . Klebsiella pneumoniae is the species most commonly involved and Klebsiella oxytoca is rare, with only nine cases reported in the literature [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] . We present a case of Klebsiella oxytoca endocarditis in a 37-year old intravenous (IV) drug user.…”