A case of Klebsiella oxytoca endocarditis in an intravenous drug user

Hauser, Naomi; Tanner, Elizabeth K.; Keuroghlian, Michael; Koduri, Lalitha

doi:10.1016/j.idcr.2017.03.003

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…This patient received a combination of imipenem, sulbactam, gentamycin and tigecycline with a good evolution, being referred to surgery after the correction of AG. There are several cases in the literature with IE caused by Klebsiella pneumonia and Klebsiella oxitoca in intravenous drug addicted [29][30][31] and hemodialysis patients 32 . Also, two cases of nosocomial IE in adults and children caused by ESBL-producing Klebsiella pneumoniae have been reported 33-34.…”

Section: Discussionmentioning

confidence: 99%

A rare case of pure white cell aplasia in a patient with thymoma complicated by infective endocarditis

Dvoretsky¹,

Yakovlev²,

Суворова³

et al. 2021

Arch Balk Med Union

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Un cas rare d'aplasie pure des globules blancs chez un patient avec un thymome compliqué d'une endocardite infectieuseIntroduction. L'aplasie pure des globules blancs (PWCA) est une maladie hématologique rare caractérisée par l'absence de lignées de neutrophiles dans la moelle osseuse avec mégacaryopoïèse et érythropoïèse intactes. La PWCA est généralement associée à plusieurs pathologies immunitaires. La cytopénie chez les patients atteints de thymome est considérée comme l'une des maladies des syndromes paranéoplasiques avec d'autres manifestations. Les deux principaux problèmes cliniques de la PWCA sont diverses complications infectieuses et les lésions ulcéreuses-nécrotiques de la peau et des muqueuses. Rapport de cas. Cet article décrit le cas rare d'un patient atteint de thymome et de l'un de ses syndromes ABSTRACT Introduction. Pure white cell aplasia (PWCA) is a rare hematologic disorder characterized by the absence of neutrophil lineages in the bone marrow, with intact megakaryopoiesis and erythropoiesis. PWCA is commonly associated with several immune pathologies. Cytopenia in patients with thymoma is a paraneoplastic syndrome, along with other manifestations. The two major clinical issues in PWCA are various infectious complications and ulcerative-necrotic lesions of the skin and mucosa membranes. Case presentation. We present a rare case of a patient with thymoma and PWCA, as paraneoplastic syndrome. On the background of agranulocytosis, the patient developed sepsis and infective endocarditis (IE) caused by a rare agent, carbapenem-resistant Klebsiella pneumoniae.Conclusions. The rarity of endocarditis caused by Klebsiella species limits its recognition and awareness

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Section: Discussionmentioning

confidence: 99%

A rare case of pure white cell aplasia in a patient with thymoma complicated by infective endocarditis

Dvoretsky¹,

Yakovlev²,

Суворова³

et al. 2021

Arch Balk Med Union

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“…Klebsiella oxytoca endocarditis is extremely rare. Only 10 other cases have been reported in the literature ( Table 1 ) [ 3 – 12 ]. They are usually found in immunocompromised patients, with a biliary, urinary, cutaneous, and sometimes peritoneal portal [ 5 ], and associated with high morbidity and mortality compared to other gram-negative bacillus endocarditis [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Infective Endocarditis Caused by Klebsiella Oxytoca in a Patient with Hemodialysis: A CARE-Compliant Case Report and Review of the Literature

Aissaoui

Hdidou

Bougrine

et al. 2020

Journal of the Saudi Heart Association

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The rarity of endocarditis due to Klebsiella species limits its recognition. We report the case of a 63-year-old man, known to have a tight calcified aortic stenosis presenting with acute heart failure associated with high fever. Klebsiella oxytoca endocarditis was diagnosed based on three sets of positive blood cultures together with fluttering vegetation (11 mm × 14 mm) on the middle segment of the anterior leaflet of the mitral valve. After 6 weeks of intravenous ceftriaxone and gentamicin bi-therapy, the patient had completely recovered. This case illustrates how sporadic this condition is, for which early assessment and proper treatment are crucial to enhance the short outcomes.

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“…Previous European studies have shown that Klebsiella pneumoniae and E. coli were the species most frequently responsible for ESBL secretion [3], especially K. pneumoniae, part of the natural intestinal microflora, but regarded as an opportunistic pathogen [4,5]. The colonization of biological tissues by K. pneumoniae frequently causes a large variety of diseases [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Biological Activities of Oregano and Lavender Essential Oils

et al. 2021

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Folk medicine uses wild herbs, especially from the Lamiaceae family, such as oregano and lavender, in the treatment of many diseases. In the present study, we investigated the antibacterial activity of the essential oils of Origanum glandulosum Desf. and Lavandula dentata L. against multidrug-resistant Klebsiella pneumoniae strains. The chemical composition of essential oils and their effect on the ultrastructure of the tested bacteria and on the release of cellular components that absorb at 260 nm were studied. Furthermore, the cytotoxicity and the production of reactive oxygen species in human lymphocytes treated with essential oils were evaluated. Thymol (33.2%) was the major constituent in O. glandulosum, and β-pinene (17.3%) was the major constituent in L. dentata. We observed ultrastructural damage in bacteria and increased release of cellular material. Furthermore, ROS production in human lymphocytes treated with essential oils was lower than in untreated lymphocytes and no cytotoxicity was observed. Therefore, the essential oils of lavender and oregano could be used as a source of natural antibacterial and antioxidant agents with potential pharmacological applications.

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A case of Klebsiella oxytoca endocarditis in an intravenous drug user

Cited by 6 publications

References 12 publications

A rare case of pure white cell aplasia in a patient with thymoma complicated by infective endocarditis

A rare case of pure white cell aplasia in a patient with thymoma complicated by infective endocarditis

Infective Endocarditis Caused by Klebsiella Oxytoca in a Patient with Hemodialysis: A CARE-Compliant Case Report and Review of the Literature

Chemical Composition and Biological Activities of Oregano and Lavender Essential Oils

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