Gout: Current Insights and Future Perspectives

Smith, Howard S.; Bracken, Donna; Smith, Joshua M.

doi:10.1016/j.jpain.2011.06.009

Cited by 41 publications

(18 citation statements)

References 90 publications

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“…In this study, the ULs of the RIs for TG, TC LDL-C, and UA are all higher than the clinical decision limits (CDLs), 21 , 22 although they became appreciably lowered by application of the LAVE method, which effectively reduced the influence of metabolic conditions. Further attempt of applying stricter exclusion criteria in the recruitment might match the RIs a little closer to the CDLs, but it makes a prior study of the RI impossible with difficulty of recruitment.…”

Section: Discussionmentioning

confidence: 63%

Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China

et al. 2016

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Section: Discussionmentioning

confidence: 63%

Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China

et al. 2016

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“…New agents such as uricase analogs and biological cytokine inhibitors have been also used for the treatment of gout [7,8]. Allopurinol, a commonly used XO inhibitor, has various adverse effects such as hypersensitivity syndrome, Stevens Johnson syndrome, renal toxicity, and fatal liver necrosis [9,10].…”

Section: Conventional Treatment Strategies and Associated Side Effectsmentioning

confidence: 99%

“…Over activity of this enzyme and increased intake of dietary food rich in nucleic acids (e.g. meat, leguminous seeds) impair renal excretion of uric acid and result in hyperuricemia and gout [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Indian Medicinal Plants Useful in Treatment of Gout: A Review for Current Status and Future Prospective

Kapoor

Kaur

Gupta

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this review is to collect and document information on the Indian medicinal plants with anti-gout potential.Methods: Bibliographic investigation was carried out by consulting worldwide scientific databases, analyzing Ayurvedic text books and research journals. The search terms were "gout," "uric acid," "hyperuricemia," "xanthine oxidase (XO) inhibitor and uricosuric." Herbal keywords included "herbal medicine," "medicinal plant," "natural products," "phytomedicine" and "phytotherapy." Result and Conclusion:Medicinal plants have been used to treat various ailments since ancient times; hence, ethnobotanical investigations play an important role in pharmacological studies. In India, traditional medicines are being practiced for the treatment of gout and other rheumatic disorders from ancient time. This review provides a comprehensive summary of 130 Indian plants which have been mentioned in ancient literature or used traditionally for the treatment of gout. Out of these, 41 plants have been reported to possess XO inhibitory activity. Further, isolated phytoconstituents having promising XO inhibitor activity are also included in this review. Although a variety of medicinal plants with anti-gout potential have been found in the literature, there is limited information on evaluation of anti-gout activity of isolated phytoconstituents. The current review contains a detailed discussion of the potential of medicinal plants for treatment of gout.

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“…Drugs like colchicines, corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) have been applied to treat acute onset of gout [9]. These drugs show good effect in the short term, but when used for a long time, gastrointestinal reactions, rashes, systemic vacuities and even renal failure would occur [10,11]. Besides, such drugs could not prevent, halt or reverse the progression of this complicated disease.…”

Section: Introductionmentioning

confidence: 99%

Chinese herbal medicine for gout: a review of the clinical evidence and pharmacological mechanisms

Chi

Zhang

et al. 2020

Chin Med

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Gout is a common arthritis condition due to disorders of purine metabolism and decreased uric acid excretion. Although researchers have carried out various studies on this disease, there are no effective drugs for patients with gout. In traditional Chinese medicine (TCM), gout pertains the category of Bi pattern due to qi stagnation in the meridians and collaterals. Chinese herbal medicinals has been employed to treat Bi patterns since the ancient China. In recent decades, classical TCM formulas and agents isolated from some Chinese herbal medicinals have been applied to treat gout and have achieved satisfactory effect. In this review, we focus on recent studies of gout in which TCM formulas were applied to treat animal models or to treat patients, and summarize the mechanism of gout from TCM perspective, the clinical application, pharmacological mechanism and the chemical compounds of TCM formulas in treating gout. In conclusion, through this study, we summarized the application principle of TCM formulas in gout treatment and some key issues of current research, and we hope this study will provide some references for applying TCM formulas to treat gout and will lay a foundation for the development of novel formulas for gout treatments.

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Gout: Current Insights and Future Perspectives

Cited by 41 publications

References 90 publications

Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China

Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China

Indian Medicinal Plants Useful in Treatment of Gout: A Review for Current Status and Future Prospective

Chinese herbal medicine for gout: a review of the clinical evidence and pharmacological mechanisms

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