Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China

Xia, Liangyu; Ming, Chen; Liu, Min; Tao, Zhihua; Li, Shijun; Wang, Liang; Cheng, Xinqi; Qin, Xuzhen; Han, Jun; Li, Pengchang; Hou, Li’an; Yu, Songlin; Ichihara, Kiyoshi; Qiu, Ling

doi:10.1097/md.0000000000002915

Cited by 39 publications

(42 citation statements)

References 20 publications

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“…Thus, we recommend establishing gender-specific RIs for GGT (r p = -0.330). This study revealed that age-or gender-specific RIs are unnecessary for K, Na, Cl, Ca, and IP, as no clinically significant differences were observed, which is consistent with the results of previous studies (17)(18)(19)(20)(21)(22)(23). Based on the results described above, the RIs of common biochemical analytes were established in this study, most of which were significantly narrower than those listed in the WS/T 404 (18)(19)(20)(21)(22)(23).…”

Section: Discussionsupporting

confidence: 92%

Gender- and age-specific reference intervals of common biochemical analytes in chinese population – derivation using real laboratory data

Wang

Zou

et al. 2019

Journal of Medical Biochemistry

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Summary Background Indirect sampling methods are not only inexpensive but also efficient for establishing reference intervals (RIs) using clinical data. This study was conducted to select fully normal records to establish age- and gender-specific RIs for common biochemical analytes by laboratory data mining. Methods In total, 280,206 records from 2014 to 2018 were obtained from Peking Union Medical College Hospital. Common biochemical analytes [total protein, albumin, total bilirubin (TBil), direct bilirubin (DBil), alanine aminotransferase (ALT), glutamyltranspeptidase (GGT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), potassium, sodium, chlorine, calcium, urea, glucose, uric acid (UA), inorganic phosphorus, creatinine (Cr), total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol] were measured using an automatic analyzer. Sources of variation were identified by multiple regression analysis. The 2.5th and 97.5th percentiles were calculated as the lower and upper limits of the RIs, respectively. Results Metode indirektnog uzorkovanja nisu samo jeftine, već su i efikasne za uspostavljanje referentnih intervala (RI) korišćenjem velike količine kliničkih podataka. Ova studija je sprovedena sa ciljem da se odaberu potpuno normalni pojedinačni zapisi da bi se utvrdio RI za starost i pol za zajedničke biohemijske analite pomoću laboratorijski dobijenih podataka. Conclusions Ukupno je uzeto 280.206 pojedinačnih rezultata u periodu od 2014. do 2018. godine iz bolnice Peking Union Medical College-a. Uobičajeni biohemijski analiti [ukupni protein, albumin, ukupni bilirubin (TBil), direktni bilirubin (DBil), alanin aminotransferaza (ALT), glutamiltranspeptidaza (GGT), alkalna fosfataza (ALP), aspartat aminotransferaza (AST), laktat dehidrogenaza (LAT) kalijum, natrijum, hlor, kalcijum, ureja, glukoza, mokraćna kiselina (UA), neorganski fosfor, kreatinin (Cr), ukupni hole sterol, trigliceridi, lipoprotein holesterola visoke gustine i lipoprotein holesterola niske gustine] mereni su korišćenjem automatskog analizatora. Izvori varijacije identifikovani su višestrukom regresionom analizom. Postoci (2,5 i 97,5) su izračunati kao donja i gornja granica RI, svaki ponaosob.

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Section: Discussionsupporting

confidence: 92%

Gender- and age-specific reference intervals of common biochemical analytes in chinese population – derivation using real laboratory data

Wang

Zou

et al. 2019

Journal of Medical Biochemistry

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“…This helps avoid exaggerated SDR for the actual narrow range of RIs or masked differences caused by the interaction between the factors. [2,21] In effect, no sex difference for all analytes was detected , which was consistent with data in different regions [8,17,22].…”

Section: Age-dependent Ris For 26 Common Biochemical Analytessupporting

confidence: 90%

“…Despite the well standardized measurements of major laboratory test, it is di cult to establish harmonized and uniform RIs on a global scale. Previous research has found that the differences in RIs of analytes are due to their complex patterns of biological sources of variations, such as region, race, diet, and more individual characteristic [1,2]. Data from the studies we have published con rms that establishing age-and sexappropriate local RIs is more accurate and reliable for providing clinical decision support, especially in pediatrics [3][4][5][6].…”

Section: Introductionmentioning

confidence: 85%

Reference Intervals for 26 Common Biochemical Analytes in Term Neonates in Jilin Province, China

Wang

Zhu

Zhou

et al. 2020

Preprint

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Background: Biochemical analytes provide information for neonatal disease management and therapy, and population-based reference intervals (RIs) are essential to accurately interpret laboratory test results. This study aimed to establish local RIs for biochemical assays in term neonates.Methods: A total of 195 healthy term neonates from birth to 3rd day were recruited as reference individuals prospectively. Analytes of 26 common biochemistries were measured using the VITROS 5600 Integrated System. The 3-level nested ANOVA was performed to assess the need for partitioning RIs of each analytes, and RIs were derived by a nonparametric method or robust method. Multiple regression analysis was used to evaluate specific correlations between the analytes and individual characteristics including age, gender, gestational age, birthweight and delivery mode.Results: There were no between-sex differences in all analytes, whereas there were significant between-day-age differences in 6 analytes. Small between-delivery-mode differences were observed in the results for potassium, phosphate, and urea. The major related factor of most analytes was postnatal age. During the first 3 days, values of iron, lipids and lipoproteins increased; creatinine, urea, uric acid, creatine kinase and lactate dehydrogenase decreased; other analytes showed slight changes or relatively stable trends. Reference limits of some analytes, particularly lactate dehydrogenase and alkaline phosphatase, were significant different from adult and pediatric groups.Conclusions: RIs of 26 common biochemical analytes are established for term neonates aged 0 to 3 days in northeast China. Additionally, it is suggested that age-related changes should be valued in the clinical decision-making process for newborns.

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“…In this study, we observed a similar association of BMI with those nutritional/inflammatory markers, but at much weaker degree: i.e., values of |rp| for ALT, CRP, GGT, and TG were all below 0.2. For TC, UL of Egyptians was 6.28 mmol/L for both sexes <45 years, comparable to other studies: Turkey 6.2(11), India 6.2(10), Saudi Arabia 6.36(12) and China 6.16 mmol/L(13),…”

Section: Discussionsupporting

confidence: 89%

Establishment of Reference Intervals of Clinical Chemistry Analytes for the Adult Population in Egypt

Baz

Ichihara

Selim

et al. 2020

Preprint

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BackgroundThis is the first Egyptian nationwide study for derivation of reference intervals (RIs) for 34 major chemistry analytes. It was conducted as a part of the global initiative by the IFCC Committee on Reference Intervals and Decision Limits (C-RIDL) for establishing country-specific RIs based on a harmonized protocol.Methods691 apparently healthy volunteers aged ≥18 years were recruited from multiple regions in Egypt. Serum specimens were analyzed in two centers. The harmonization and standardization of test results were achieved by measuring value-assigned serum panel provided by C-RIDL. The RIs were calculated by parametric method. Sources of variation of reference values (RVs) were evaluated by multiple regression analysis. The need for partitioning by sex, age, and region was judged primarily by standard deviation ratio (SDR).ResultsGender-specific RIs were required for six analytes including total bilirubin (TBil), aspartate and alanine aminotransferase (AST, ALT). Seven analytes required age-partitioning including glucose and low-density lipoprotein cholesterol (LDL-C)., Regional differences were observed between northern and southern Egypt for direct bilirubin, glucose, and high-density-lipoprotein cholesterol (HDL-C) with all their RVs lower in southern Egypt. Compared with other collaborating countries, the features of Egyptian RVs were lower HDL-C and TBil and higher TG and C-reactive protein. In addition, BMI showed weak association with most of nutritional markers. These features were shared with two other Middle Eastern countries: Saudi Arabia and Turkey.ConclusionThe standardized RIs established by this study can be used as common Egyptian RI, except for a few analytes that showed regional differences. Despite high prevalence of obesity among Egyptians, their RVs of nutritional markers are less sensitive to increased BMI, compared to other collaborating countries.

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Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China

Abstract: Supplemental Digital Content is available in the text

Cited by 39 publications

References 20 publications

Gender- and age-specific reference intervals of common biochemical analytes in chinese population – derivation using real laboratory data

Gender- and age-specific reference intervals of common biochemical analytes in chinese population – derivation using real laboratory data

Reference Intervals for 26 Common Biochemical Analytes in Term Neonates in Jilin Province, China

Establishment of Reference Intervals of Clinical Chemistry Analytes for the Adult Population in Egypt

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