Gorham Stout Syndrome (Disappearing Bone Disease)

Lee, Samson; Finn, Laura S.; Sze, Raymond W.; Perkins, Jonathan A.; Sie, Kathleen C.Y.

doi:10.1001/archotol.129.12.1340

Cited by 66 publications

(19 citation statements)

References 15 publications

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“…Ethology is not clear. Osteolysis secondary to angiomatosis [9], increased osteoclast activity due to high level of IL6 [2] and minor traumas are accused [1]. Our patient gave a history of minor trauma in childhood.…”

Section: Discussionmentioning

confidence: 74%

Case Report: Gorham-Stoute Syndrome with Involvement of Majority of Mandible, and Partial Maxillary, Temporal and Zygomatic Bones

Evrenos

Özkaya

Yaman

et al. 2015

J. Maxillofac. Oral Surg.

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The Gorham-Stout syndrome is a rare condition in which spontaneous, progressive resorption of bone occurs. The diagnosis is based on clinical, radiological and histopathological findings after excluding other etiologies and as a result it is often delayed. We present the case of a 21-year-old male diagnosed with Gorham-Stout syndrome with involvement of the majority of the mandible, partial involvement of right maxillary, temporal and zygomatic bones and discuss its diagnostic and therapeutic features.

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Section: Discussionmentioning

confidence: 74%

Case Report: Gorham-Stoute Syndrome with Involvement of Majority of Mandible, and Partial Maxillary, Temporal and Zygomatic Bones

Evrenos

Özkaya

Yaman

et al. 2015

J. Maxillofac. Oral Surg.

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“…However, other authors have found osteoclasts in the affected tissue, suggesting that bone resorption is caused by increased osteoclast activity [10] and is mediated by stimulating cytokines such as interleukin-6 [11]. Although the etiology is unknown, up to 50% of the cases are associated with previous trauma [12]. This disease usually affects young people without predilection for sex, race or genetic transmission.…”

Section: Discussionmentioning

confidence: 99%

Gorham-Stout Disease and Cerebrospinal Fluid Otorrhea

Hernández-Marqués

González²,

Ortega³

et al. 2011

Pediatr Neurosurg

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Objective and Importance: Gorham-Stout disease is a rare entity characterized by vascular proliferation causing local destruction of bone tissue. Owing to its low incidence and variable clinical presentation, the diagnosis requires a high degree of awareness by the clinician. Clinical Presentation: We present the case of a 2-year-old boy diagnosed of Gorham-Stout syndrome with involvement of the temporal bone and secondary cerebrospinal fluid (CSF) leakage. Intervention: Because of the CSF leakage, the patient required two surgical interventions. The second intervention included mastectomy and placement of a patch and a lumbar drainage device during 50 days, after which the leakage ceased. Conclusion: Gorham-Stout disease is a rare condition that can affect the skull base and even present with CSF leakage.

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“…As a general rule, the persons that suffer from the disease are younger than 40-year-old [16] , while an epidemiologic correlation with race, gender and geography does not seem to exist [9,[17][18][19] . However, some authors noticed a clear "predilection" of the disease in males [20] .…”

Section: Clinical Featuresmentioning

confidence: 99%

Vanishing bone disease (Gorham-Stout syndrome): A review of a rare entity

Nikolaou¹

2014

WJO

102

104

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Vanishing bone disease (Gorham-Stout syndrome) is a rare entity of unknown etiology, characterized by destruction of osseous matrix and proliferation of vascular structures, resulting in destruction and absorption of bone. Despite the extensive investigation of the pathogenetic mechanisms of the disease, its etiology hasn't been clarified and several theories exist. The syndrome can affect one or multiple bones of the patient, including the skull, the upper and lower extremities, the spine and pelvis. The clinical presentation of a patient suffering from vanishing bone disease includes, pain, functional impairment and swelling of the affected region, although asymptomatic cases have been reported, as well as cases in which the diagnosis was made after a pathologic fracture. In this short review we summarize the theories regarding the etiology as well as the clinical presentation, the diagnostic approach and treatment options of this rare disease.© 2014 Baishideng Publishing Group Inc. All rights reserved. Key words:Vanishing bone disease; Gorham-Stout syndrome; Histology; Diagnosis; Treatment Core tip: Vanishing bone disease (Gorham-Stout syndrome) is a rare entity of unknown etiology, characterized by destruction of osseous matrix and proliferation of vascular structures, resulting in destruction and absorption of bone. The syndrome can affect one or multiple bones of the patient, including the skull, the upper and lower extremities, the spine and pelvis. Physicians should be aware of the existence of this rare entity and reliably direct affected patients to right diagnosis and therapeutic approach.

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Gorham Stout Syndrome (Disappearing Bone Disease)

Cited by 66 publications

References 15 publications

Case Report: Gorham-Stoute Syndrome with Involvement of Majority of Mandible, and Partial Maxillary, Temporal and Zygomatic Bones

Case Report: Gorham-Stoute Syndrome with Involvement of Majority of Mandible, and Partial Maxillary, Temporal and Zygomatic Bones

Gorham-Stout Disease and Cerebrospinal Fluid Otorrhea

Vanishing bone disease (Gorham-Stout syndrome): A review of a rare entity

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