Vanishing bone disease (Gorham-Stout syndrome): A review of a rare entity

Abstract

Vanishing bone disease (Gorham-Stout syndrome) is a rare entity of unknown etiology, characterized by destruction of osseous matrix and proliferation of vascular structures, resulting in destruction and absorption of bone. Despite the extensive investigation of the pathogenetic mechanisms of the disease, its etiology hasn't been clarified and several theories exist. The syndrome can affect one or multiple bones of the patient, including the skull, the upper and lower extremities, the spine and pelvis. The clinical presentation of a patient suffering from vanishing bone disease includes, pain, functional impairment and swelling of the affected region, although asymptomatic cases have been reported, as well as cases in which the diagnosis was made after a pathologic fracture. In this short review we summarize the theories regarding the etiology as well as the clinical presentation, the diagnostic approach and treatment options of this rare disease.© 2014 Baishideng Publishing Group Inc. All rights reserved. Key words:Vanishing bone disease; Gorham-Stout syndrome; Histology; Diagnosis; Treatment Core tip: Vanishing bone disease (Gorham-Stout syndrome) is a rare entity of unknown etiology, characterized by destruction of osseous matrix and proliferation of vascular structures, resulting in destruction and absorption of bone. The syndrome can affect one or multiple bones of the patient, including the skull, the upper and lower extremities, the spine and pelvis. Physicians should be aware of the existence of this rare entity and reliably direct affected patients to right diagnosis and therapeutic approach.

From tooth extraction to Gorham-Stout disease: A case report

“…Decisions regarding the management of GSD are influenced by many factors, as the disease, although considered to be benign and spontaneously resolving, is characterised by an unpredictable prognosis and possible serious complications [39].…”

What does vanishing bone disease look like?

“…GSD or ‘vanishing bone’ disease is a rare disorder, characterised by the destruction of osseous matrix due to aggressive proliferation of non-neoplastic vascular and lymphatic tissue, similar to a haemangioma or lymphangioma 1. Only 64 cases have been reported in the literature, 8 of which have involved the humerus.…”

Pleural Effusion in Gorham-Stout Syndrome: A Case Report and a Literature Review

“…Although this disease is considered benignant, the prognosis can be very poor. Complications of this disease include pleural effusion, that can seriously impair respiratory function [2]. Few cases are reported about pleural effusion in Gorham-Stout syndrome.…”