Gondoic acid alleviates LPS‑induced Kupffer cells inflammation by inhibiting ROS production and PKCθ/ERK/STAT3 signaling pathway

Fan, Guoqiang; Li, Yanfei; Liu, Yaxin; Suo, Xiaoyi; Jia, Yimin; Yang, Xiaojing

doi:10.1016/j.intimp.2022.109171

Cited by 11 publications

(5 citation statements)

References 54 publications

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“…Gondoic acid is relatively rare and is found in high quantities in jojoba oil [26], and less in rapeseed, mustard seed [20], and camelina [27] oils. Research on the nutritional value and health effects of gondoic acid is still in its early stages, with varying findings from neutral effects on mortality and cardiovascular health [28], to positive effects in inhibiting inflammation [29], to potentially negative effects on glucose metabolism [30].…”

Section: Discussionmentioning

confidence: 99%

Chemical Profile of Cold-Pressed Beech Nut (Fagus sylvatica L.) Oil

Obranović,

Kraljić,

Škevin

et al. 2024

Nutraceuticals

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The objective of this study was to assess the chemical characteristics of cold-pressed beech nut oil. The nuts, gathered from the forest, comprised 25.35% water, 13.19% oil, and 19.40% protein. The predominant fatty acid was linoleic acid (40.5%), followed by oleic acid (35.0%) and gondoic acid (7.7%). All four tocopherols were present in the oil, with γ-tocopherol being the dominant form at 99.38 mg per 100 g of oil. The total sterol content was 2708.73 mg per kg of oil, with β-sitosterol constituting 80.5% of all sterols. The main characteristics of the oil included its relatively high tocopherol and gondoic acid content, a dominant oleic–linoleic fatty acid profile, and elevated levels of carotenoids.

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Section: Discussionmentioning

confidence: 99%

Chemical Profile of Cold-Pressed Beech Nut (Fagus sylvatica L.) Oil

Obranović,

Kraljić,

Škevin

et al. 2024

Nutraceuticals

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“…Some research has investigated whether STAT3 mediates the accumulation of ROS. It was demonstrated that several compounds improved intracellular in ammation through the inhibition of ROS production and the STAT3 signaling pathway 39,40 . Serene et al con rmed that exposing neuronal cells to increasing concentrations of both oligomeric and brillar α-syn (10-40 nmol/L) resulted in stepwise increases in cellular ROS production 24 .…”

Section: Discussionmentioning

confidence: 99%

STAT3-mediated ferroptosis is involved in α-synuclein pathology

Lin,

Zhang,

Huang

et al. 2024

Parkinsonism & Related Disorders

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“…[33] GA has been reported to improve Kupffer cell inflammation by inhibiting the production of ROS and PKCθ/ERK/STAT3 pathway. [34] The molecular docking results showed that GA exhibits good binding affinity to MAPK14 and GSK3B. It is worth noting that so far, few studies have been conducted on the use of cavidine and GA in insomnia treatment.…”

Section: Discussionmentioning

confidence: 99%

Molecular targets and mechanisms involved in the action of Banxia Shumi decoction in insomnia treatment

Zhang

Zhang²,

Wang³

et al. 2023

Medicine

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Insomnia is a common sleep-wake rhythm disorder, which is closely associated with the occurrence of many serious diseases. Recent researches suggest that circadian rhythms play an important role in regulating sleep duration and sleep quality. Banxia Shumi decoction (BSXM) is a well-known Chinese formula used to treat insomnia in China. However, the overall molecular mechanism behind this therapeutic effect has not yet been fully elucidated. This study aimed to identify the molecular targets and mechanisms involved in the action of BSXM during the treatment of insomnia. Using network pharmacology and molecular docking methods, we investigated the molecular targets and underlying mechanisms of action of BSXM in insomnia therapy. We identified 8 active compounds from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and the traditional Chinese medicine integrative database that corresponded to 26 target genes involved in insomnia treatment. The compound-differentially expressed genes of the BXSM network indicated that cavidine and gondoic acid could potentially become key components of drugs used for insomnia treatment. Further analysis revealed that GSK3B, MAPK14, IGF1R, CCL5, and BCL2L11 were core targets significantly associated with the circadian clock. Pathway enrichment analysis of Kyoto Encyclopedia of Genes and Genomes revealed that epidermal growth factor receptor tyrosine kinase inhibitor resistance was the most prominently enriched pathway for BSXM in the insomnia treatment. The forkhead box O signaling pathway was also found to be significantly enriched. These targets were validated using the Gene Expression Omnibus dataset. Molecular docking studies were performed to confirm the binding of cavidine and gondoic acid to the identified core targets. To our knowledge, our study confirmed for the first time that the multi-component, multi-target, and multi-pathway characteristics of BXSM may be the potential mechanism for treating insomnia with respect to the circadian clock gene. The results of this study provided theoretical guidance for researchers to further explore its mechanism of action.Abbreviations: BCL2L1 = BCL2 like 1, BSXM = Banxia Shumi decoction, DEGs = differentially expressed genes, EGFR = epidermal growth factor receptor, FOXO = forkhead box O, GO = gene ontology, GA = gondoic acid, GSEA = gene set enrichment analysis, KEGG = Kyoto Encyclopedia of Genes and Genomes, MAPK14 = mitogen-activated protein kinase, MCC = maximum cluster centrality, PPI = protein-protein interaction, ROC = receiver operating characteristic, SD = sleep deprivation, TCM = traditional Chinese medicine.

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Gondoic acid alleviates LPS‑induced Kupffer cells inflammation by inhibiting ROS production and PKCθ/ERK/STAT3 signaling pathway

Cited by 11 publications

References 54 publications

Chemical Profile of Cold-Pressed Beech Nut (Fagus sylvatica L.) Oil

Chemical Profile of Cold-Pressed Beech Nut (Fagus sylvatica L.) Oil

STAT3-mediated ferroptosis is involved in α-synuclein pathology

Molecular targets and mechanisms involved in the action of Banxia Shumi decoction in insomnia treatment

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