Gold-palladium nanoparticles aided electrochemically reduced graphene oxide sensor for the simultaneous estimation of lomefloxacin and amoxicillin

Kumar, Neeraj; Rosy, .; Goyal, Rajendra N.

doi:10.1016/j.snb.2016.12.025

Cited by 95 publications

(27 citation statements)

References 45 publications

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“…The sensitivity of developed sensor was higher in comparison with large majority of other reported voltammetric and amperometric sensors . Taking into account the detection limit of developed sensor is lower than sensors described in literature . The last parameter–linear response range is comparable or slightly narrower than linear ranges for other electrochemical sensors.…”

Section: Resultsmentioning

confidence: 99%

Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

et al. 2018

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In this work, a novel voltammetric sensor was developed to determine amoxicillin (AMX). The electrode modification layer consisted of titanium dioxide sol (TiO2) modified with gold nanoparticles (AuNPs), CMK‐3‐type mesoporous carbon and Nafion. The morphology of the electrode composite was studied by scanning electron microscopy (SEM). Electrochemical behaviour of AMX at proposed electrode was studied. Effects of parameters comprising the amount of CMK‐3 and AuNPs in matrix composite, pH of supporting electrolyte and incubation time on the sensitivity of developed sensor were examined. The analytical characteristics of the proposed sensor were assessed. The developed sensor exhibited linear response in two AMX concentration ranges: from 0.5 to 2.5 μM and from 2.5 to 133.0 μM, with sensitivity of 1420 μA mM−1 (5071 μA mM−1 cm−2) and 832 μA mM−1 (2971 μA mM−1 cm−2), respectively. The detection limit was evaluated as 0.3 μM. For verification purposes the sensor was successfully employed in determination of AMX in pharmaceutical product, mineral and environmental water using a flow‐batch monosegmented sequential injection approach.

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Section: Resultsmentioning

confidence: 99%

Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

et al. 2018

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“…The study of this class of compounds is crucial for obtaining their metabolic, pharmacological, toxicological and pharmacokinetic behavior, especially since they are usually prescribed as an alternative to patients who are allergic to penicillin . The electrochemical determination of a number of cephalosporins has been investigated at GCE, boron doped diamond electrodes, dropping mercury electrodes, electrodes modified with CNT or other nanostructured materials, but their redox processes vary depending on the electroactive moieties of each pharmaceutical compound. Their determination in wastewater has also been addressed, given that they act as contaminants .…”

Section: Introductionmentioning

confidence: 99%

Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

2020

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The electrochemical characterization and determination of the antibiotic cefadroxil were carried out at multi-walled carbon nanotube (CNT) and gold nanoparticle (AuNP) modified glassy carbon electrodes (GCE). Oxidation of the phenol moiety of cefadroxil occurred at slightly less-positive potentials and with a higher current response than at bare GCE. Differential pulse voltammetry and electrochemical impedance spectroscopy showed that the architecture combining CNT and AuNP surface modification is the best in pH 7 buffer solution. Scanning electron microscopy demonstrated good coverage of the AuNPs on the CNTs. The fixed potential amperometric determination of cefadroxil was carried out at + 0.74 V vs Ag/AgCl with a limit of detection of 0.22 μM. Analysis of cefadroxil in commercial samples presented high recovery values and the amount of the pharmaceutical in each capsule was in excellent agreement with that measured by UV/Vis spectroscopy.

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“…Gold-palladium (Au-Pd) nanocomposite is a bimetallic nanomaterial that has been widely applied in the field of biosensing because of its biocompatibility, high catalytic ability, and large surface-to-volume ratio [25]. However, the bimetallic material easily aggregates at nanometer dimensions, a characteristic that prohibits more extensive applications.…”

Section: Introductionmentioning

confidence: 99%

A Label-Free Electrochemical Immunosensor for Detection of the Tumor Marker CA242 Based on Reduced Graphene Oxide-Gold-Palladium Nanocomposite

Zheng

Zhang

et al. 2019

Nanomaterials

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As a tumor marker, carbohydrate antigen 24-2 (CA242) is a highly accurate and specific diagnostic indicator for monitoring pancreatic and colorectal cancers. The goal of this study was to create a novel label-free electrochemical immunosensor using a nanocomposite glassy carbon electrode for the detection of CA242. Graphene oxide (GO) and polyvinyl pyrrolidone were chosen as the dopants for the preparation of a high-performance reduced-GO-gold-palladium (rGO-Au-Pd) nanocomposite. RGO-Au-Pd was characterized using X-ray diffraction and transmission electron microscopy, revealing that the material exhibited superior electrochemical redox activity and electron transfer ability. The effects of the synthesis method, material concentration, reduction cycle, and pH were investigated to optimize the performance of the immunosensor. As a result of the catalytic activity and biocompatibility of rGO-Au-Pd, the prepared CA242 immunosensor displayed a wide linear range of detection from 0.001 U/mL to 10,000 U/mL with a detection limit of 1.54 × 10−3 U/mL and a sensitivity of 4.24 μA (log10CCA242)−1. More importantly, the immunosensor exhibited satisfactory reproducibility and selectivity when detected CA242 in PBS or human serum. The results of our study provide a platform for the development of novel bioassays for use in early cancer diagnosis and promote the application of biosensing technology in the medical field.

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Gold-palladium nanoparticles aided electrochemically reduced graphene oxide sensor for the simultaneous estimation of lomefloxacin and amoxicillin

Cited by 95 publications

References 45 publications

Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

A Label-Free Electrochemical Immunosensor for Detection of the Tumor Marker CA242 Based on Reduced Graphene Oxide-Gold-Palladium Nanocomposite

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Gold-palladium nanoparticles aided electrochemically reduced graphene oxide sensor for the simultaneous estimation of lomefloxacin and amoxicillin

Cited by 95 publications

References 45 publications

Sensitive Voltammetric Amoxicillin Sensor Based on TiO2 Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

Sensitive Voltammetric Amoxicillin Sensor Based on TiO2 Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

A Label-Free Electrochemical Immunosensor for Detection of the Tumor Marker CA242 Based on Reduced Graphene Oxide-Gold-Palladium Nanocomposite

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Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles