Gold Nanostructure: Fabrication, Surface Modification, Targeting Imaging, and Enhanced Radiotherapy

Wu, Di; Zhang, Xiaodong; Liu, Peixun; Liang-an, Zhang; Fan, Feiyue; Guo, Meili

doi:10.2174/157341311794480246

Cited by 27 publications

(11 citation statements)

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“…43 With increase in particle size, the SPR will shift to long-wavelength regions, which is consistent with the reported results. 44 The PEG 2000 coating is not macromolecules, thus it is not expected that the SPR will shift obviously. Actually, we found that PEG 2000 only made a very tiny contribution to SPR shift.…”

Section: Tem and Spectrophotometermentioning

confidence: 99%

Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

Chen

Wang²,

Long³

et al. 2013

IJN

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Gold nanoparticles have received wide interest in disease diagnosis and therapy, but one of the important issues is their toxicological effects in vivo. Sex differences in the toxicity of gold nanoparticles are not clear. In this work, body weight, organ weight, hematology, and biochemistry were used to evaluate sex differences in immune response and liver and kidney damage. Pathology was used to observe the general toxicity of reproductive organs. The immune response was influenced significantly in female mice, with obvious changes in spleen and thymus index. Hematology results showed that male mice treated with 22.5 nm gold nanoparticles received more significant infection and inflammation than female mice. Meanwhile, the biochemistry results showed that 4.4 and 22.5 nm gold nanoparticles caused more significant liver damage in male mice than female mice, while 22.5, 29.3, and 36.1 nm gold nanoparticles caused more significant kidney damage in female mice than male mice. No significant toxicological response was found in the reproductive system for female or male mice. It was found that gold nanoparticles caused more serious liver toxicity and infection in male mice than female mice. These findings indicated that sex differences may be one of the important elements for in vivo toxicity of gold nanoparticles.

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Section: Tem and Spectrophotometermentioning

confidence: 99%

Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

Chen

Wang²,

Long³

et al. 2013

IJN

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“…1,2 Because of their strong and size-tunable surface plasmon resonance, fluorescence, and easy surface functionalization, gold-based nanomaterials have been widely used in biosensors, cancer cell imaging, photothermal therapy, and drug delivery. [3][4][5][6][7][8][9] Recently, gold nanoparticles have been suggested as a novel radiosensitizer technique in radiotherapy, because their strong photoelectric absorption and secondary electron caused by gamma or X-ray irradiation can accelerate DNA strand breakage. [10][11][12] Therefore, it was necessary to investigate the toxicity of these materials.…”

Section: Introductionmentioning

confidence: 99%

Size-dependent in vivo toxicity of PEG-coated gold nanoparticles

Zhang¹,

Wu²,

Shen³

et al. 2011

IJN

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389

246

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Background: Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of 5, 10, 30, and 60 nm PEG-coated gold nanoparticles in mice. Methods: Animal survival, weight, hematology, morphology, organ index, and biochemistry were characterized at a concentration of 4000 µg/kg over 28 days. Results:The PEG-coated gold particles did not cause an obvious decrease in body weight or appreciable toxicity even after their breakdown in vivo. Biodistribution results show that 5 nm and 10 nm particles accumulated in the liver and that 30 nm particles accumulated in the spleen, while the 60 nm particles did not accumulate to an appreciable extent in either organ. Transmission electron microscopic observations showed that the 5, 10, 30, and 60 nm particles located in the blood and bone marrow cells, and that the 5 and 60 nm particles aggregated preferentially in the blood cells. The increase in spleen index and thymus index shows that the immune system can be affected by these small nanoparticles. The 10 nm gold particles induced an increase in white blood cells, while the 5 nm and 30 nm particles induced a decrease in white blood cells and red blood cells. The biochemistry results show that the 10 nm and 60 nm PEG-coated gold nanoparticles caused a significant increase in alanine transaminase and aspartate transaminase levels, indicating slight damage to the liver. Conclusion: The toxicity of PEG-coated gold particles is complex, and it cannot be concluded that the smaller particles have greater toxicity. The toxicity of the 10 nm and 60 nm particles was obviously higher than that of the 5 nm and 30 nm particles. The metabolism of these particles and protection of the liver will be more important issues for medical applications of gold-based nanomaterials in future.

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“…The AgNPs has been known to be a potent antibacterial, antifungal and antiviral agent, AgNPS are used as therapeutic agents for the treatment of renal failure, cirrhosis, cardiovascular diseases, anticancer therapy, and diabetes and so on. The gold nanoclusters with small size was reported to penetrate kidney tissue and have promise to decrease in vivo toxicity by renal clearance [77]. Inorganic NPs exhibit long half-life, stronger signal outputs and more biomedical functionalities than other nanopreparations [33,34,[78][79][80].…”

Section: In Vitro Animal Studiesmentioning

confidence: 99%

Patho-physiological studies of human blood with kidney dysfunction and therapeutics of albumin functionalized silver nanoparticles in mice kidney cells in vitro

Sironmani¹,

Bhattarai²

2018

Trends Med

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The incidence of acute kidney injury and disease is increasing alarmingly. Inflammatory or nutritional status are associated with kidney disease/ Serum albumin is the marker to identify malnutrition in patients with chronic kidney disease. Treatment with albumin functionalized green synthesized silver nanoparticles help maintain and restore normal cellular function in the kidney. The role of albumin in kidney cell metabolism was studied in-vitro and showed a profound influence of albumin with or without nanoparticles on the level of protein, glucose, and catalase activity. The albumin-nanoparticle treated cells were observed to be healthier as evidenced from the morphology of the cells. Elevated levels of 66 kDa, 59 kDa, 45 kDa, 34, 29 kDa proteins were observed. The proteins may be Heat shock proteins which has cytoprotective properties. The antimicrobial properties of the silver nanoparticles control the infection and inflammation. This novel nanopreparation could lead to the new therapeutics in the treatment of renal injury restoring renal function. Research highlight• Hypoalbuminemia, is highly prevalent in kidney failure and is associated with an increased mortality risk reflecting either the inflammatory or nutritional status of patients• To understand the relationship between malnutrition and serum albumin dosed through functionalized silver nanoparticles the current study was carried out in patients with illness and in organ culture using mice kidney in vitro.• The Albumin functionalized silver nanoparticles were effective combating inflammation and degradation of cellular and extracellular matrix, transporting nutrition to the damaged nephrons prompting self-repair to maintain the status of protein and fat metabolism to avoid dialysis and to support the kidney to work properly preventing acute renal failure.• Besides, the nanoformulation strengthen the immune system to fight chronic problems reducing the oxidative stress and infection preventing acute renal failure.

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Gold Nanostructure: Fabrication, Surface Modification, Targeting Imaging, and Enhanced Radiotherapy

Cited by 27 publications

References 0 publications

Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

Size-dependent in vivo toxicity of PEG-coated gold nanoparticles

Patho-physiological studies of human blood with kidney dysfunction and therapeutics of albumin functionalized silver nanoparticles in mice kidney cells in vitro

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