Gold Nanorod-based Photo-PCR System for One-Step, Rapid Detection of Bacteria

Kim, Jinjoo; Kim, Hansol; Park, Ji Ho; Jon, Sangyong

doi:10.7150/ntno.18720

Cited by 40 publications

(32 citation statements)

References 31 publications

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“…NPs applications in biodetection is huge and more insights on pathogen detection using NPs platforms can be seen in Veigas et al ( 2013 , 2014 , 2015 ); Costa et al ( 2014 ); Weng et al ( 2015 ); Kim J. et al ( 2017 ); Wang et al ( 2017b ); Galvan and Yu ( 2018 ), and Yang et al ( 2018 ).…”

Section: The Potential For Nanotheranosticsmentioning

confidence: 99%

“…NPs have also been applied with tremendous success in biodetection systems, namely as sensors and diagnostics platforms with increased sensitivity and selectivity. Due to the decrease in size of the transduction mechanisms provided by NPs, most of these platforms have found applications at point-of-need and/or point-of-care (Costa et al, 2014 ; Veigas et al, 2014 ; Weng et al, 2015 ; Kim J. et al, 2017 ; Wang et al, 2017b ; Galvan and Yu, 2018 ; Yang et al, 2018 ). In some cases, diagnostics/sensing and therapeutic properties have been combined onto single NPs, providing for innovative tools – Nanotheranostics.…”

Section: Other Potential Applications Of Npsmentioning

confidence: 99%

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Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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Infectious diseases remain one of the leading causes of morbidity and mortality worldwide. The WHO and CDC have expressed serious concern regarding the continued increase in the development of multidrug resistance among bacteria. Therefore, the antibiotic resistance crisis is one of the most pressing issues in global public health. Associated with the rise in antibiotic resistance is the lack of new antimicrobials. This has triggered initiatives worldwide to develop novel and more effective antimicrobial compounds as well as to develop novel delivery and targeting strategies. Bacteria have developed many ways by which they become resistant to antimicrobials. Among those are enzyme inactivation, decreased cell permeability, target protection, target overproduction, altered target site/enzyme, increased efflux due to over-expression of efflux pumps, among others. Other more complex phenotypes, such as biofilm formation and quorum sensing do not appear as a result of the exposure of bacteria to antibiotics although, it is known that biofilm formation can be induced by antibiotics. These phenotypes are related to tolerance to antibiotics in bacteria. Different strategies, such as the use of nanostructured materials, are being developed to overcome these and other types of resistance. Nanostructured materials can be used to convey antimicrobials, to assist in the delivery of novel drugs or ultimately, possess antimicrobial activity by themselves. Additionally, nanoparticles (e.g., metallic, organic, carbon nanotubes, etc.) may circumvent drug resistance mechanisms in bacteria and, associated with their antimicrobial potential, inhibit biofilm formation or other important processes. Other strategies, including the combined use of plant-based antimicrobials and nanoparticles to overcome toxicity issues, are also being investigated. Coupling nanoparticles and natural-based antimicrobials (or other repurposed compounds) to inhibit the activity of bacterial efflux pumps; formation of biofilms; interference of quorum sensing; and possibly plasmid curing, are just some of the strategies to combat multidrug resistant bacteria. However, the use of nanoparticles still presents a challenge to therapy and much more research is needed in order to overcome this. In this review, we will summarize the current research on nanoparticles and other nanomaterials and how these are or can be applied in the future to fight multidrug resistant bacteria.

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Section: The Potential For Nanotheranosticsmentioning

confidence: 99%

Section: Other Potential Applications Of Npsmentioning

confidence: 99%

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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“…Plasmonic light-to-heat energy conversion contributed to a breakthrough ultrashort polymerase chain reaction cycle time of 30 cycles in 54 seconds [218]. This has induced more modifications with various plasmon generation methods, such as those involving the use of nanorods [219], Pt thin films [220], and Au thin films [221]. Plasmonic light-to-heat energy conversion is beneficial for rapid and precise heating in polymerase chain reaction.…”

Section: Plasmonic Light-to-heat Conversionmentioning

confidence: 99%

Review of Experimental Setups for Plasmonic Photocatalytic Reactions

Huang

Chiang

et al. 2019

Catalysts

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Plasmonic photocatalytic reactions have been substantially developed. However, the mechanism underlying the enhancement of such reactions is confusing in relevant studies. The plasmonic enhancements of photocatalytic reactions are hard to identify by processing chemically or physically. This review discusses the noteworthy experimental setups or designs for reactors that process various energy transformation paths for enhancing plasmonic photocatalytic reactions. Specially designed experimental setups can help characterize near-field optical responses in inducing plasmons and transformation of light energy. Electrochemical measurements, dark-field imaging, spectral measurements, and matched coupling of wavevectors lead to further understanding of the mechanism underlying plasmonic enhancement. The discussions herein can provide valuable ideas for advanced future studies.

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“…It exploits the light-to-heat conversion mediated by plasmonic substrates [26][27][28][29] . This concept has been adopted for PCR thermocycling, in the form of a planar plasmonic substrate in a fluidic device 20,30,31 or metallic nanoparticles in suspension 22,32,33 . Both methods have shown fast nucleic acid ampli-fication, but challenges remain: nucleic acids after amplification are difficult to detect because plasmonic substrates would interfere with fluorescence reporters 34,35 .…”

mentioning

confidence: 99%