Gold Nanorod Assisted Enhanced Plasmonic Detection Scheme of COVID‐19 SARS‐CoV‐2 Spike Protein

Das, Chandreyee Manas; Guo, Yan; Yuan, Guang; Kang, Lixing; Xu, Gaixia; Ho, Ho-Pui; Yong, Ken‐Tye

doi:10.1002/adts.202000185

Cited by 68 publications

(64 citation statements)

References 64 publications

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“…In the beginning, the proposed hybrid sensor performance was analyzed at different excitation wavelengths. Commercially available SPR biosensors such as Biacore-3000, SPRm-200, and Spreeta-2000 operate at a wavelength of 690 nm, 780 nm, and 830 nm, respectively [ 64 , 65 ]. The RI of sensor materials changes during the different excitation wavelengths, which is tabulated in Table 1 [ 34 ].…”

Section: Quality Enhancement Of the Proposed Sensormentioning

confidence: 99%

Design and Numerical Analysis of a Graphene-Coated SPR Biosensor for Rapid Detection of the Novel Coronavirus

Akib

Mou

Rahman

et al. 2021

Sensors

108

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In this paper, a highly sensitive graphene-based multiple-layer (BK7/Au/PtSe2/Graphene) coated surface plasmon resonance (SPR) biosensor is proposed for the rapid detection of the novel Coronavirus (COVID-19). The proposed sensor was modeled on the basis of the total internal reflection (TIR) technique for real-time detection of ligand-analyte immobilization in the sensing region. The refractive index (RI) of the sensing region is changed due to the interaction of different concentrations of the ligand-analyte, thus impacting surface plasmon polaritons (SPPs) excitation of the multi-layer sensor interface. The performance of the proposed sensor was numerically investigated by using the transfer matrix method (TMM) and the finite-difference time-domain (FDTD) method. The proposed SPR biosensor provides fast and accurate early-stage diagnosis of the COVID-19 virus, which is crucial in limiting the spread of the pandemic. In addition, the performance of the proposed sensor was investigated numerically with different ligand-analytes: (i) the monoclonal antibodies (mAbs) as ligand and the COVID-19 virus spike receptor-binding domain (RBD) as analyte, (ii) the virus spike RBD as ligand and the virus anti-spike protein (IgM, IgG) as analyte and (iii) the specific probe as ligand and the COVID-19 virus single-standard ribonucleic acid (RNA) as analyte. After the investigation, the sensitivity of the proposed sensor was found to provide 183.33°/refractive index unit (RIU) in SPR angle (θSPR) and 833.33THz/RIU in SPR frequency (SPRF) for detection of the COVID-19 virus spike RBD; the sensitivity obtained 153.85°/RIU in SPR angle and 726.50THz/RIU in SPRF for detection of the anti-spike protein, and finally, the sensitivity obtained 140.35°/RIU in SPR angle and 500THz/RIU in SPRF for detection of viral RNA. It was observed that whole virus spike RBD detection sensitivity is higher than that of the other two detection processes. Highly sensitive two-dimensional (2D) materials were used to achieve significant enhancement in the Goos-Hänchen (GH) shift detection sensitivity and plasmonic properties of the conventional SPR sensor. The proposed sensor successfully senses the COVID-19 virus and offers additional (1 + 0.55) × L times sensitivity owing to the added graphene layers. Besides, the performance of the proposed sensor was analyzed based on detection accuracy (DA), the figure of merit (FOM), signal-noise ratio (SNR), and quality factor (QF). Based on its performance analysis, it is expected that the proposed sensor may reduce lengthy procedures, false positive results, and clinical costs, compared to traditional sensors. The performance of the proposed sensor model was checked using the TMM algorithm and validated by the FDTD technique.

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Section: Quality Enhancement Of the Proposed Sensormentioning

confidence: 99%

Design and Numerical Analysis of a Graphene-Coated SPR Biosensor for Rapid Detection of the Novel Coronavirus

Akib

Mou

Rahman

et al. 2021

Sensors

108

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“…Das and his colleagues designed and simulated a plasmonic immunoassay, in 2020, which comprised of sandwich plasmonic biosensor whose sensitivity was enhanced by using gold nanorods. They have varied the prismatic configuration and found that the BK-7 glass-based sensor has a sensitivity of 111.11 deg./RIU [ 21 ]. They also varied the distance of the gold NRs and their aspect ratio and recorded their observations.…”

Section: Sensing Using Plasmonic Biosensorsmentioning

confidence: 99%

“…They claimed that their sensor had a limit of detection of around 4.2 fmol and sample-to-result duration was around 80 min [ 3 ]. In the same year, Das et al designed a gold nanorod-based plasmonic sensor to detect COVID-19 with a sensitivity of 111.11 deg./ RIU [ 21 ]. In 2018, Ahmed et al devised a sensor using magneto-plasmonic nanoparticles for coronavirus detection.…”

Section: Plasmonic Biosensors For Coronavirus Detectionmentioning

confidence: 99%

A review on plasmonic and metamaterial based biosensing platforms for virus detection

Hassan

Sium

Islam

et al. 2021

Sensing and Bio-Sensing Research

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Due to changes in our climate and constant loss of habitat for animals, new pathogens for humans are constantly erupting. SARS-CoV-2 virus, become so infectious and deadly that they put new challenge to the whole technological advancement of healthcare. Within this very decade, several other deadly virus outbreaks were witnessed by humans such as Zika virus, Ebola virus, MERS-coronavirus etc. and there might be even more infectious and deadlier diseases in the horizon. Though conventional techniques have succeeded in detecting these viruses to some extent, these techniques are time-consuming, costly, and require trained human-resources. Plasmonic metamaterial based biosensors might pave the way to low-cost rapid virus detection. So this review discusses in details, the latest development in plasmonics and metamaterial based biosensors for virus, viral particles and antigen detection and the future direction of research in this field.

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“…Then, samples containing the antigen were allowed to flow as an analyte. This work was assisted by a simulation technique to study the effect of ARs and arrangements of the gold nanorods [ 29 ].…”

Section: Novel Biosensing Strategies Used For Covid-19 Diagnosismentioning

confidence: 99%

Analysis of Recent Bio-/Nanotechnologies for Coronavirus Diagnosis and Therapy

Rhouati

Teniou

Badea

et al. 2021

Sensors

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Despite barrier measures and physical distancing tailored by the populations worldwide, coronavirus continues to spread causing severe health and social-economic problems. Therefore, researchers are focusing on developing efficient detection and therapeutic platforms for SARS-CoV2. In this context, various biotechnologies, based on novel molecules targeting the virus with high specificity and affinity, have been described. In parallel, new approaches exploring nanotechnology have been proposed for enhancing treatments and diagnosis. We discuss in the first part of this review paper, the different biosensing and rapid tests based on antibodies, nucleic acids and peptide probes described since the beginning of the pandemic. Furthermore, given their numerous advantages, the contribution of nanotechnologies is also highlighted.

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Gold Nanorod Assisted Enhanced Plasmonic Detection Scheme of COVID‐19 SARS‐CoV‐2 Spike Protein

Cited by 68 publications

References 64 publications

Design and Numerical Analysis of a Graphene-Coated SPR Biosensor for Rapid Detection of the Novel Coronavirus

Design and Numerical Analysis of a Graphene-Coated SPR Biosensor for Rapid Detection of the Novel Coronavirus

A review on plasmonic and metamaterial based biosensing platforms for virus detection

Analysis of Recent Bio-/Nanotechnologies for Coronavirus Diagnosis and Therapy

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