Gold nanoparticles loaded into niosomes: A novel approach for enhanced antitumor activity against human ovarian cancer

Amale, Farideh Rezaie; Ferdowsian, Shaghayegh; Hajrasouliha, Shadi; Kazempoor, Reza; Mirzaie, Amir; Dakkali, Mohammad Sedigh; Akbarzadeh, Iman; Meybodi, Seyed Mohammadmahdi; Mirghafouri, M Reza

doi:10.1016/j.apt.2021.10.019

Cited by 40 publications

(14 citation statements)

References 73 publications

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“…Rezaie Amale et al loaded gold nanoparticles into niosomes and evaluated their cytotoxic effects against a human ovarian cancer cell line. The results of this study indicated that niosomes-loaded gold nanoparticles had dose-dependent cytotoxicity effects and had more significant cytotoxic effects than free gold nanoparticles 51 . Xuan et al synthesized a co-delivery system consisting of SeNPs@liposome and investigated its cytotoxic effects against lung cancer (A549) and cervical cancer (HeLa) cell lines using the MTT assay.…”

Section: Resultsmentioning

confidence: 71%

Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities

Haddadian

Robattorki

Dibah

et al. 2022

Sci Rep

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Targeted drug delivery and increasing the biological activity of drugs is one of the recent challenges of pharmaceutical researchers. Niosomes are one of the new targeted drug delivery systems that enhances the biological properties of drugs. In this study, for the first time, the green synthesis of selenium nanoparticles (SeNPs), and its loading into niosome was carried out to increase the anti-bacterial and anti-cancer activity of SeNPs. Different formulations of noisome-loaded SeNPs were prepared, and the physical and chemical characteristics of the prepared niosomes were investigated. The antibacterial and anti-biofilm effects of synthesized niosomes loaded SeNPs and free SeNPs against standard pathogenic bacterial strains were studied, and also its anticancer activity was investigated against breast cancer cell lines. The expression level of apoptotic genes in breast cancer cell lines treated with niosome-loaded SeNPs and free SeNPs was measured. Also, to evaluate the biocompatibility of the synthesized niosomes, their cytotoxicity effects against the human foreskin fibroblasts normal cell line (HFF) were studied using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The results illustrated that the optimal formulation had an average size of 177.9 nm, a spherical shape, and an encapsulation efficiency of 37.58%. Also, the results revealed that the release rate of SeNPs from niosome-loaded SeNPs and free SeNPs was 61.26% and 100%, respectively, in 72 h. Also, our findings demonstrated that the niosome-loaded SeNPs have significant antibacterial, anti-biofilm, and anticancer effects compared to the free SeNPs. In addition, niosome-loaded SeNPs can upregulate the expression level of Bax, cas3, and cas9 apoptosis genes while the expression of the Bcl2 gene is down-regulated in all studied cell lines, significantly. Also, the results of the MTT test indicated that the free niosome has no significant cytotoxic effects against the HFF cell line which represents the biocompatibility of the synthesized niosomes. In general, based on the results of this study, it can be concluded that niosomes-loaded SeNPs have significant anti-microbial, anti-biofilm, and anti-cancer effects, which can be used as a suitable drug delivery system.

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Section: Resultsmentioning

confidence: 71%

Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities

Haddadian

Robattorki

Dibah

et al. 2022

Sci Rep

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“…Thickness and core radius of AuNPs can produce a comparable result. 116 This allows the development of AuNRs and gold nanoshells (AuNSs) with unique properties according to the tumor's size and location. 117 Furthermore, the aggregations of AuNPs have been found to have a considerable influence on both optical and thermal characteristics.…”

Section: Applications Of Metal‐based Nms In Different Types Of Cancermentioning

confidence: 99%

“…Gold nanorods (AuNRs) with different widths and lengths can affect the absorption and scattering band from visible to NIR. Thickness and core radius of AuNPs can produce a comparable result 116 . This allows the development of AuNRs and gold nanoshells (AuNSs) with unique properties according to the tumor's size and location 117 .…”

Section: Applications Of Metal‐based Nms In Different Types Of Cancermentioning

confidence: 99%

Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

Kumar

Shukla

Sharma

et al. 2023

MedComm

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Cancer is a disease associated with complex pathology and one of the most prevalent and leading reasons for mortality in the world. Current chemotherapy has challenges with cytotoxicity, selectivity, multidrug resistance, and the formation of stemlike cells. Nanomaterials (NMs) have unique properties that make them useful for various diagnostic and therapeutic purposes in cancer research. NMs can be engineered to target cancer cells for early detection and can deliver drugs directly to cancer cells, reducing side effects and improving treatment efficacy. Several of NMs can also be used for photothermal therapy to destroy cancer cells or enhance immune response to cancer by delivering immune‐stimulating molecules to immune cells or modulating the tumor microenvironment. NMs are being modified to overcome issues, such as toxicity, lack of selectivity, increase drug capacity, and bioavailability, for a wide spectrum of cancer therapies. To improve targeted drug delivery using nano‐carriers, noteworthy research is required. Several metal‐based NMs have been studied with the expectation of finding a cure for cancer treatment. In this review, the current development and the potential of plant and metal‐based NMs with their effects on size and shape have been discussed along with their more effective usage in cancer diagnosis and treatment.

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“…So, niosomes have capability to encapsulate both hydrophilic and hydrophobic drugs. [17,18] Moreover, since niosomes are sensitive to pH, different niosomal formulations have been used as nanocarriers in treatment of cancer cells with smallest side effect on normal cells. [19,20] In the current study, niosomal nanocarriers loaded with Artemisia turcomanic were designed.…”

Section: Introductionmentioning

confidence: 99%

“…As nonionic amphiphiles are composed of hydrophilic head groups and hydrophobic tails, dispersal of those in water cause hydrophobic part to shield from the aqueous medium through the hydrophilic head groups. So, niosomes have capability to encapsulate both hydrophilic and hydrophobic drugs [17,18] . Moreover, since niosomes are sensitive to pH, different niosomal formulations have been used as nanocarriers in treatment of cancer cells with smallest side effect on normal cells [19,20] .…”

Section: Introductionmentioning

confidence: 99%

Preparation of Artemisia Turcomanic Encapsulated Niosomal Nanocarriers and Evaluation of Anticancer Activities and Apoptosis Gene Expression Analysis in HeLa Cells

Eslamian

Keshtmand

Hesampour

2023

Chemistry & Biodiversity

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Artemisia turcomanic as a natural antibacterial agent, exhibited significant antibacterial effect in the treatment against cancer. This study is the first to investigate size, encapsulation efficiencies, release behavior of Artemisia turcomanic loaded niosomal nanocarriers, and the anticancer effect of niosomal nanocarriers by MTT assay, flow cytometry, and real time (on HeLa cell lines). When the molar ratio of cholesterol: surfactant was 1 : 2 and the liquid content was 300 μmol, the highest percentage of entrapment efficiency was 83.25 %. Moreover, niosomal formulation showed a pH-dependent release; a slowrelease profile in physiological pH (7.4), and a more significant release rate at acidic conditions (pH = 5.4). In addition, The apoptotic rate of Artemisia loaded niosomes on HeLa cell lines was higher than free extract and pristine niosome. Also, reduction in the expression levels of Bcl2, caspase-3, and p53 genes and increase in the expression level of BAX after treatment with Artemisia turcomanic-loaded niosomes were more significant than those after treatment with free Artemisia turcomanic and blank niosome. The cytotoxicity results of samples presented that Artemisia turcomanic loaded niosomes are more beneficial in the death of HeLa cell lines.

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Gold nanoparticles loaded into niosomes: A novel approach for enhanced antitumor activity against human ovarian cancer

Cited by 40 publications

References 73 publications

Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities

Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities

Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

Preparation of Artemisia Turcomanic Encapsulated Niosomal Nanocarriers and Evaluation of Anticancer Activities and Apoptosis Gene Expression Analysis in HeLa Cells

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