Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

Kumar, Sunil; Shukla, Monu Kumar; Sharma, Abhishek Kumar; Jayaprakash, Gururaj K; Tonk, Rajiv Kumar; Chellappan, Dinesh Kumar; Singh, Sachin Kumar; Dua, Kamal; Ahmed, Faheem; Bhattacharyya, Sanjib; Kumar, Deepak

doi:10.1002/mco2.253

Cited by 15 publications

(3 citation statements)

References 285 publications

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“…PEGylated NPs have been shown to inhibit biofilm formation and bacterial growth of P. aeruginosa. Furthermore, PLGA NPs have been reported to demonstrate antimicrobial activity against MRSA and VRE . Further, studies have shown that drug-encapsulated chitosan NPs exhibit antibacterial activity against S. aureus and E. coli.…”

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

“…154 Furthermore, PLGA NPs have been reported to demonstrate antimicrobial activity against MRSA and VRE. 90 Further, studies have shown that drug-encapsulated chitosan NPs exhibit antibacterial activity against S. aureus and E. coli. 155 Moreover, drug-loaded chitosan NPs have also been explored to control biofilm formation by fungal pathogens.…”

Section: Metal and Metal Oxidementioning

confidence: 99%

“…Compared to other nanomaterials, MNPs have a high surface-to-volume ratio. They are characterized by their excellent optical characteristics and substantial electric field enhancement, enabling their prospective use in bioimaging, sensors, and therapies . Metal NPs have emerged as promising candidates for controlling biofilms due to their physicochemical properties. , Several studies have reported the anti-biofilm activity of metal NPs against a wide range of bacterial pathogens .…”

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

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Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

Section: Metal and Metal Oxidementioning

confidence: 99%

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

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Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Valladão,

da Silva,

Souza

2024

Macromolecular Symposia

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The present investigation offers a thorough bibliometric exploration spotlighting the pivotal utilization of zinc oxide nanostructures, encompassing both zero‐dimensional (0D) nanoparticles and one‐dimensional (1D) nanostructures, within the realm of nanotechnology‐driven drug delivery systems. This analysis particularly illuminates the distinctive potential of these nanostructures in the cancer therapy context, not merely as carriers and deliverers of pharmaceutical agents, but as entities capable of selectively inducing apoptosis in cancer cells through the orchestrated generation of reactive oxygen species (ROS). Recent research endeavors notably underscore the application prospects of ZnO nanostructures in domains like DNA cleavage, bioimaging, and agricultural defense mechanisms. Moreover, the study elucidates the pronounced enhancement in solubility and biocompatibility that these nanostructures bring about when harmoniously integrated into polymeric nanocomposites. Concomitantly, the involvement of polymers in this symbiotic system is unveiled, wherein they play a multifaceted role in dictating release selectivity, thereby facilitating targeted and efficacious interactions with tissues. Functionally engineered polymeric nanocomposites emerge as promising candidates for targeted delivery modalities in cancer treatment, demonstrating an affinity for specific cell receptors and exhibiting enhanced cellular uptake within the size range of 100–200 nm. The study unearths robust associations among pivotal research terminologies through an exhaustive analysis of Link Strength Between Items (LSBI), culminating in the presentation of a cogent map delineating the evolving trends and forthcoming trajectories in this dynamic domain. In summation, this all‐encompassing bibliometric inquiry serves as a poignant testament to the prodigious potential of zinc oxide nanostructures in the realm of forthcoming nanotechnology‐driven drug delivery paradigms.

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Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

Kumar

Shukla

Sharma

et al. 2023

MedComm

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Cancer is a disease associated with complex pathology and one of the most prevalent and leading reasons for mortality in the world. Current chemotherapy has challenges with cytotoxicity, selectivity, multidrug resistance, and the formation of stemlike cells. Nanomaterials (NMs) have unique properties that make them useful for various diagnostic and therapeutic purposes in cancer research. NMs can be engineered to target cancer cells for early detection and can deliver drugs directly to cancer cells, reducing side effects and improving treatment efficacy. Several of NMs can also be used for photothermal therapy to destroy cancer cells or enhance immune response to cancer by delivering immune‐stimulating molecules to immune cells or modulating the tumor microenvironment. NMs are being modified to overcome issues, such as toxicity, lack of selectivity, increase drug capacity, and bioavailability, for a wide spectrum of cancer therapies. To improve targeted drug delivery using nano‐carriers, noteworthy research is required. Several metal‐based NMs have been studied with the expectation of finding a cure for cancer treatment. In this review, the current development and the potential of plant and metal‐based NMs with their effects on size and shape have been discussed along with their more effective usage in cancer diagnosis and treatment.

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Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

Cited by 15 publications

References 285 publications

Advances in Nanotechnology for Biofilm Inhibition

Advances in Nanotechnology for Biofilm Inhibition

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

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