Gold Nanoparticles for Tissue Engineering

Borzenkov, Mykola; Chirico, Giuseppe; Collini, Maddalena; Pallavicini, Piersandro

doi:10.1007/978-3-319-76090-2_10

Cited by 11 publications

(11 citation statements)

References 255 publications

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“…Au NPs are currently widely used in various biomedical applications, such as genomics, clinical chemistry, laser phototherapy of cancer cells, targeted delivery of drugs, and many more (Figure 8), due to the favorable chemical and physical properties, in particular the high stability and facile synthetic preparation techniques [110,111]. Au NPs possess a wide range of unique properties, in particular the tunable optical resonances, easy surface functionalization, and well-controlled size and shape, that make them versatile platforms for different applications [111][112][113][114].…”

Section: Au Nanoparticles (Au Nps)mentioning

confidence: 99%

Inorganic Nanomaterials in Tissue Engineering

et al. 2022

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In recent decades, the demand for replacement of damaged or broken tissues has increased; this poses the attention on problems related to low donor availability. For this reason, researchers focused their attention on the field of tissue engineering, which allows the development of scaffolds able to mimic the tissues’ extracellular matrix. However, tissue replacement and regeneration are complex since scaffolds need to guarantee an adequate hierarchical structured morphology as well as adequate mechanical, chemical, and physical properties to stand the stresses and enhance the new tissue formation. For this purpose, the use of inorganic materials as fillers for the scaffolds has gained great interest in tissue engineering applications, due to their wide range of physicochemical properties as well as their capability to induce biological responses. However, some issues still need to be faced to improve their efficacy. This review focuses on the description of the most effective inorganic nanomaterials (clays, nano-based nanomaterials, metal oxides, metallic nanoparticles) used in tissue engineering and their properties. Particular attention has been devoted to their combination with scaffolds in a wide range of applications. In particular, skin, orthopaedic, and neural tissue engineering have been considered.

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Section: Au Nanoparticles (Au Nps)mentioning

confidence: 99%

Inorganic Nanomaterials in Tissue Engineering

et al. 2022

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“…Some metal biomaterials including antioxidants were built for tissue engineering studies. For instance, gold nanoparticles are a tool in tissue engineering [ 95 ] to ameliorate mechanical properties of the biomaterial and to guide specific cell behaviour [ 96 ]. Resveratrol is a feasible reducing agent for the synthesis of gold nanoparticles avoiding self-agglomeration and enabling additional drug loading [ 97 ].…”

Section: New Opportunities For Natural Antioxidant Combination Witmentioning

confidence: 99%

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Marrazzo

O’Leary

2020

Bioengineering

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Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments can be realized with the development of biocompatible redox-modulating materials. The incorporation of antioxidant compounds within implanted biomaterials should be able to retain the antioxidant activity, while also allowing graft survival and tissue recovery. This review summarizes the recent literature reporting the combined role of natural antioxidants with biomaterials. Our review highlights how such functionalization is a promising strategy in tissue engineering to improve the engraftment and promote tissue healing or regeneration.

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“…Metal-based nanomaterials are widely utilized in tissue engineering studies because of their unique physical, chemical, and biological properties . Among the various introduced metal nanomaterials, the most studied for cardiac tissue engineering applications are gold nanomaterials (AuNMs) because of their biocompatibility and high electrical conductivity . Fabrication methods, in addition to their special structural and functional features, make them favorable platforms for biomedical applications (reviewed in ref ).…”

Section: Gold-based Nanomaterialsmentioning

confidence: 99%

“…159 Among the various introduced metal nanomaterials, the most studied for cardiac tissue engineering applications are gold nanomaterials (AuNMs) because of their biocompatibility and high electrical conductivity. 160 Fabrication methods, in addition to their special structural and functional features, make them favorable platforms for biomedical applications (reviewed in ref 161). We intend to discuss the behavior of AuNMs-based constructs in cardiac tissue engineering applications from the cellular point of view.…”

Section: Gold-based Nanomaterialsmentioning

confidence: 99%

Multifunctional Conductive Biomaterials as Promising Platforms for Cardiac Tissue Engineering

Mousavi

Vahdat

Baheiraei

et al. 2020

ACS Biomater. Sci. Eng.

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Adult cardiomyocytes are terminally differentiated cells that result in minimal intrinsic potential for the heart to self-regenerate. The introduction of novel approaches in cardiac tissue engineering aims to repair damages from cardiovascular diseases. Recently, conductive biomaterials such as carbon- and gold-based nanomaterials, conductive polymers, and ceramics that have outstanding electrical conductivity, acceptable mechanical properties, and promoted cell–cell signaling transduction have attracted attention for use in cardiac tissue engineering. Nevertheless, comprehensive classification of conductive biomaterials from the perspective of cardiac cell function is a subject for discussion. In the present review, we classify and summarize the unique properties of conductive biomaterials considered beneficial for cardiac tissue engineering. We attempt to cover recent advances in conductive biomaterials with a particular focus on their effects on cardiac cell functions and proposed mechanisms of action. Finally, current problems, limitations, challenges, and suggested solutions for applications of these biomaterials are presented.

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Gold Nanoparticles for Tissue Engineering

Cited by 11 publications

References 255 publications

Inorganic Nanomaterials in Tissue Engineering

Inorganic Nanomaterials in Tissue Engineering

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Multifunctional Conductive Biomaterials as Promising Platforms for Cardiac Tissue Engineering

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