Inorganic Nanomaterials in Tissue Engineering

Bianchi, Eleonora; Vigani, Barbara; Viseras, César; Ferrari, Franca; Rossi, Silvia; Sandri, Giuseppina

doi:10.3390/pharmaceutics14061127

Cited by 32 publications

(22 citation statements)

References 153 publications

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“…The advantageous presence of a stabilizing and protecting agent ( i.e. , polyvinylpyrrolidone, PVP) could minimize the particle aggregation and control the reduction rate of silver ions, allowing obtainment of a stable solution of AgNCs in the long term. − Additionally, the presence of PVP moieties promises a good dispersion of these nanocubes in the aqueous environment, which will be used further as the precursor solution for the preparation of the PAAm/AgNCs hydrogel.…”

Section: Resultsmentioning

confidence: 99%

In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface

Rinoldi

Ziai

Zargarian

et al. 2022

ACS Appl. Mater. Interfaces

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In neuroscience, the acquisition of neural signals from the brain cortex is crucial to analyze brain processes, detect neurological disorders, and offer therapeutic brain−computer interfaces. The design of neural interfaces conformable to the brain tissue is one of today's major challenges since the insufficient biocompatibility of those systems provokes a fibrotic encapsulation response, leading to an inaccurate signal recording and tissue damage precluding long-term/permanent implants. The design and production of a novel soft neural biointerface made of polyacrylamide hydrogels loaded with plasmonic silver nanocubes are reported herein. Hydrogels are surrounded by a silicon-based template as a supporting element for guaranteeing an intimate neural-hydrogel contact while making possible stable recordings from specific sites in the brain cortex. The nanostructured hydrogels show superior electroconductivity while mimicking the mechanical characteristics of the brain tissue. Furthermore, in vitro biological tests performed by culturing neural progenitor cells demonstrate the biocompatibility of hydrogels along with neuronal differentiation. In vivo chronic neuroinflammation tests on a mouse model show no adverse immune response toward the nanostructured hydrogel-based neural interface. Additionally, electrocorticography acquisitions indicate that the proposed platform permits long-term efficient recordings of neural signals, revealing the suitability of the system as a chronic neural biointerface.

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Section: Resultsmentioning

confidence: 99%

In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface

Rinoldi

Ziai

Zargarian

et al. 2022

ACS Appl. Mater. Interfaces

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“…In addition to natural and synthetic polymers, inorganic materials, such as metal oxides (MOs), metal nanoparticles (NPs), and carbon-based nanomaterials (NMs) are being intensively studied for TE applications [ 21 ]. Layered silicate nanoclays have been widely pursued for dermatological and musculoskeletal applications [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning Inorganic Nanomaterials to Fabricate Bionanocomposites for Soft and Hard Tissue Repair

Cui

Shen

et al. 2023

Nanomaterials

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Tissue engineering (TE) has attracted the widespread attention of the research community as a method of producing patient-specific tissue constructs for the repair and replacement of injured tissues. To date, different types of scaffold materials have been developed for various tissues and organs. The choice of scaffold material should take into consideration whether the mechanical properties, biodegradability, biocompatibility, and bioresorbability meet the physiological properties of the tissues. Owing to their broad range of physico-chemical properties, inorganic materials can induce a series of biological responses as scaffold fillers, which render them a good alternative to scaffold materials for tissue engineering (TE). While it is of worth to further explore mechanistic insight into the use of inorganic nanomaterials for tissue repair, in this review, we mainly focused on the utilization forms and strategies for fabricating electrospun membranes containing inorganic components based on electrospinning technology. A particular emphasis has been placed on the biological advantages of incorporating inorganic materials along with organic materials as scaffold constituents for tissue repair. As well as widely exploited natural and synthetic polymers, inorganic nanomaterials offer an enticing platform to further modulate the properties of composite scaffolds, which may help further broaden the application prospect of scaffolds for TE.

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Section: Introductionmentioning

confidence: 99%

“…Inorganic nanomaterials have recently gained great attention in tissue engineering, in particular to dope polymeric scaffolds [ 9 , 10 ]. In fact, they have unique properties, such as antimicrobial, antioxidant, and anti-inflammatory properties, and thus they have been widely used to improve polymeric scaffold mechanical properties, and to support and enhance the cell growth [ 9 , 10 ]. In particular, in the tissue engineering field, CuO nanoparticles proved to stimulate cell proliferation during wound healing by upregulating the vascular endothelial growth factor gene expression, promoting mesenchymal stem cell differentiation, and avoiding infections via their antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Scaffolds Based on Poly(butyl cyanoacrylate) for Tendon Tissue Engineering

Bianchi

Vigani

Ruggeri

et al. 2023

IJMS

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Tendon disorders are common medical conditions that could lead to significant disability, pain, healthcare costs, and a loss of productivity. Traditional approaches require long periods of treatment, and they largely fail due to the tissues weakening and the postoperative alterations of the normal joint mechanics. To overcome these limitations, innovative strategies for the treatment of these injuries need to be explored. The aim of the present work was the design of nano-fibrous scaffolds based on poly(butyl cyanoacrylate) (PBCA), a well-known biodegradable and biocompatible synthetic polymer, doped with copper oxide nanoparticles and caseinphosphopeptides (CPP), able to mimic the hierarchical structure of the tendon and to improve the tissue healing potential. These were developed as implants to be sutured to reconstruct the tendons and the ligaments during surgery. PBCA was synthetized, and then electrospun to produce aligned nanofibers. The obtained scaffolds were characterized for their structure and physico-chemical and mechanical properties, highlighting that CuO and CPP loading, and the aligned conformation determined an increase in the scaffold mechanical performance. Furthermore, the scaffolds loaded with CuO showed antioxidant and anti-inflammatory properties. Moreover, human tenocytes adhesion and proliferation to the scaffolds were assessed in vitro. Finally, the antibacterial activity of the scaffolds was evaluated using Escherichia coli and Staphylococcus aureus as representative of Gram-negative and Gram-positive bacteria, respectively, demonstrating that the CuO-doped scaffolds possessed a significant antimicrobial effect against E. coli. In conclusion, scaffolds based on PBCA and doped with CuO and CPP deserve particular attention as enhancers of the tendon tissue regeneration and able to avoid bacterial adhesion. Further investigation on the scaffold efficacy in vivo will assess their capability for enhancing the tendon ECM restoration in view of accelerating their translation to the clinic.

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Inorganic Nanomaterials in Tissue Engineering

Cited by 32 publications

References 153 publications

In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface

In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface

Electrospinning Inorganic Nanomaterials to Fabricate Bionanocomposites for Soft and Hard Tissue Repair

Electrospun Scaffolds Based on Poly(butyl cyanoacrylate) for Tendon Tissue Engineering

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