Gold nanoparticle-filled biodegradable photopolymer scaffolds induced muscle remodeling: in vitro and in vivo findings

Zsedényi, Ádám; Farkas, Balázs; Abdelrasoul, Gaser N.; Romano, Ilaria; Gyukity-Sebestyen, Edina; Nagy, Katalin; Harmati, Mária; Dobra, Gabriella; Körmöndi, Sándor; Decsi, Gábor; Németh, István; Diaspro, Alberto; Brandi, F.; Beke, Szabolcs; Buzás, Krisztina

doi:10.1016/j.msec.2016.11.124

Cited by 9 publications

(9 citation statements)

References 20 publications

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“…Both synthetic (e.g. polypropylene fumarate/diethyl fumarate; PPF/DEF [133], PCL [134], PU [135] and poly(ethylene glycol) diacrylate; PEG-DA) [136]) and natural polymers [132] (e.g. HA [135]) have been used as starting materials with SLA.…”

Section: Cytocompatibility Of Porous Materials Fabrication Processesmentioning

confidence: 99%

“…However, the small number of visible-light photopolymerizable solutions and photoinitiators with low cytotoxicity, such as lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) [141] and eosin Y disodium salt [140], limits the applications of SLA for cell-laden constructs. Nonetheless, SLA presents the best resolution in fabricating three-dimensional scaffolds among the SFF techniques [122], which can be further improved down to the nanoscale with microstereolithography (MSTL) [142], digital mask projection [133] or by means of two-photon polymerization processes [143].…”

Section: Cytocompatibility Of Porous Materials Fabrication Processesmentioning

confidence: 99%

See 1 more Smart Citation

Colonization versus encapsulation in cell-laden materials design: porosity and process biocompatibility determine cellularization pathways

Parisi

Qin

Fernandes

2021

Phil. Trans. R. Soc. A.

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Seeding materials with living cells has been—and still is—one of the most promising approaches to reproduce the complexity and the functionality of living matter. The strategies to associate living cells with materials are limited to cell encapsulation and colonization, however, the requirements for these two approaches have been seldom discussed systematically. Here we propose a simple two-dimensional map based on materials' pore size and the cytocompatibility of their fabrication process to draw, for the first time, a guide to building cellularized materials. We believe this approach may serve as a straightforward guideline to design new, more relevant materials, able to seize the complexity and the function of biological materials. This article is part of the theme issue ‘Bio-derived and bioinspired sustainable advanced materials for emerging technologies (part 1)’.

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Section: Cytocompatibility Of Porous Materials Fabrication Processesmentioning

confidence: 99%

Section: Cytocompatibility Of Porous Materials Fabrication Processesmentioning

confidence: 99%

Colonization versus encapsulation in cell-laden materials design: porosity and process biocompatibility determine cellularization pathways

Parisi

Qin

Fernandes

2021

Phil. Trans. R. Soc. A.

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“…Terranova et al [114] introduced porous polystyrene (PS) microfibers prepared by grafting GNPs surfacefunctionalized with mercaptosuccinic acid,which improved bone reconstruction in a model of critical size calvarial defect in mice with β-Tricalcium phosphate(β-TCP). Polypropylene fumarate (PPF): diethyl fumarate (DEF) (7,3 w/w) biodegradable photocurable polymers with incorporated GNPs [115] and electrospun poly(Llactide) and gold nanoparticle composite scaffolds [116] can be applied to musculoskeletal tissue engineering, all of which are representative of the conductive, biodegradable scaffolds incorporated into GNPs (Table 2).…”

Section: Composite Synthetic Polymermentioning

confidence: 99%

“…When he doped BM-MSC with 1 mM gold chloride in phosphate buffer saline at pH 7.4 for 28 days, the growth of BM-MSC to approximate 90% degree of fusion showed intracellular GNPs accumulation. Their research provided the theoretical basis and prerequisites PS,β-TCP human mesenchymal stem cells (hMSCs) cytocompatibility, biocompatibility [114] PPF,DEF adipose stem cells (ASCs) induced muscle tissue regeneration [115] Poly(L-lactic acid) (PLLA) Muscle cells biodegradable, biocompatible and conductive scaffold for skeletal muscle repair [116] for the subsequent application in BTE. The previous studies are MSC.…”

Section: Medical Imagingmentioning

confidence: 99%

Advances in the application of gold nanoparticles in bone tissue engineering

Xia

et al. 2020

J Biol Eng

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The materials used in bone tissue engineering (BTE) have been advancing with each passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs), which are easy to be synthesized and functionalized, have attracted increasing attention. Recent years have witnessed this amazing material, i.e., GNPs characterized with large surface area to volume ratio, biocompatibility, medical imaging property, hypotoxicity, translocation into the cells, high reactivity, and other properties, perform distinct functions in BTE. However, the low stability of GNPs in the biotic environment makes them in the requirements of modification or recombination before being used. After being combined with the advantages of other materials, the structures of GNPs have exhibited great potential in stem cells, scaffolds, delivery systems, medical imaging, and other aspects. This review will focus on the advances in the application of GNPs after modification or recombination with other materials to BTE.

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“…Besides coating, materials can be mixed into the feedstock: Au nanoparticles (NPs) were incorporated into PPF/DEF scaffolds [137] showing greater adipose stem cell adhesion in vitro than without the Au NPs, while in vivo tests showed absence of immune response in animals, offering a significant step towards tissue regeneration [138]. Hydroxyapatite NPs have similarly been incorporated into PPF membranes which allow controlled release of the NPs as the film degrades [139].…”

Section: Bioactivitymentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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Gold nanoparticle-filled biodegradable photopolymer scaffolds induced muscle remodeling: in vitro and in vivo findings

Cited by 9 publications

References 20 publications

Colonization versus encapsulation in cell-laden materials design: porosity and process biocompatibility determine cellularization pathways

Colonization versus encapsulation in cell-laden materials design: porosity and process biocompatibility determine cellularization pathways

Advances in the application of gold nanoparticles in bone tissue engineering

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

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