Gold nanoparticle-based colorimetric methods to determine protein contents in artificial urine using membrane micro-concentrators and mobile phone camera

Lai, Teh-Sheng; Chang, Ting-Chou; Wang, Shau‐Chun

doi:10.1016/j.snb.2016.07.158

Cited by 46 publications

(24 citation statements)

References 32 publications

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“…The surface properties of the channel change greatly when entering the nanometric channel scale from the micrometric scale with electric field, such as partial overlap of the electric double layer (EDL) in the channel, increase in viscosity and decrease in dielectric constant . The size of the nanofluidic channel is similar to that of biomacromolecules and proteins . Therefore, the nanofluidic chip can be used for single molecule detection, control and separation analysis of biological macromolecules .…”

Section: Introductionmentioning

confidence: 99%

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

Han

Chen

2019

J of Chemical Tech & Biotech

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Lab-on-a-chip has been used widely in rapid, high-throughput and low-consumption analysis of samples in biochemistry. The ion concentration polarization (ICP) produced by ion-selective transport of nanochannels provides a novel solution for problems in ultra-low concentration sample detection, systems biology and desalination. This paper reviews the applications of ion transport based on the principle of ICP in micro-nanofluidic systems. First, the fundamental governing equations of ICP are described. Then, the applications of nano-electrokinetic ion enrichment and ion current rectification (ICR) are introduced. Nano-electrokinetic ion enrichment is used mainly in the fields of molecular enrichment, ultra-low concentration sample detection and seawater desalination. ICR is applied mainly to the sensitive detection of analytical substances such as proteins, nucleic acids and small molecules. The application of ion transport based on ICP principle is summarized and the possible directions worthy of further research are proposed.

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Section: Introductionmentioning

confidence: 99%

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

Han

Chen

2019

J of Chemical Tech & Biotech

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“…The current equation is an ad hoc function aiming at describing the system behavior for the full range of concentrations with few fitting parameters, and to predict the shape of correct responses for result validation. The use of an equation for image processing was also reported by Lai et al [25].…”

Section: Semiquantification Using a Pca Acceptance/rejection Systemmentioning

confidence: 74%

A Hybrid Lab-on-a-Chip Injector System for Autonomous Carbofuran Screening

Tsagkaris

Pulkrabová

Hajšlová

et al. 2019

Sensors

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Securing food safety standards is crucial to protect the population from health-threatening food contaminants. In the case of pesticide residues, reference procedures typically find less than 1% of tested samples being contaminated, thus indicating the necessity for new tools able to support smart and affordable prescreening. Here, we introduce a hybrid paper–lab-on-a-chip platform, which integrates on-demand injectors to perform multiple step protocols in a single disposable device. Simultaneous detection of enzymatic color response in sample and reference cells, using a regular smartphone, enabled semiquantitative detection of carbofuran, a neurotoxic and EU-banned carbamate pesticide, in a wide concentration range. The resulting evaluation procedure is generic and allows the rejection of spurious measurements based on their dynamic responses, and was effectively applied for the binary detection of carbofuran in apple extracts.

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“…Whenever the nanoparticles aggregate, the red color of AuNP solution turns to blue. AuNPs are aggregated due to changes in solution composition or particle surface properties to minimize electrostatic or hydrogen bonding interactions …”

Section: Resultsmentioning

confidence: 99%

“…AuNPs are aggregated due to changes in solution composition or particle surface properties to minimize electrostatic or hydrogen bonding interactions. 24 It was observed that AuNPs aggregated in acidic medium, and consequently, in the presence of MG, a color change from red to blue was observed. Scheme 1 explains the fundamental idea of MG detection.…”

Section: Resultsmentioning

confidence: 99%

Sensitive, simple and rapid colorimetric detection of malachite green in water, salmon and canned tuna samples based on gold nanoparticles

Heleyel

Elhami

2018

J Sci Food Agric

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BACKGROUND Malachite green is used in aquaculture and fisheries as a fungicide and antiseptic and it is also used in industry as a dye. However, malachite green is carcinogenic and highly toxic for humans and animals. In this study, a spectrophotometric method was developed to detect malachite green. The method was based on the surface plasmon resonance property of gold nanoparticles and interaction between malachite green and gold nanoparticles. RESULTS Malachite green–gold nanoparticles were rapidly aggregated in the acidic medium; as a result, a color change from red to blue was observed, which was easily detectable by the naked eye. The absorption ratio (A623/A520) of the gold nanoparticles in an optimized system exhibited a linear correlation with malachite green concentration. The method detection limit and linear range were 3 and 50–350 ng mL−1, respectively. The method was applied successfully to detect malachite green in different samples. CONCLUSION The method was simple and rapid to detect malachite green. The most important advantages of the method are the possibility of malachite green determination with very good accuracy and sensitivity using a simple UV–visible spectrometer without any expensive or sophisticated instrumentation and also the versatility of real samples. © 2018 Society of Chemical Industry

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Gold nanoparticle-based colorimetric methods to determine protein contents in artificial urine using membrane micro-concentrators and mobile phone camera

Cited by 46 publications

References 32 publications

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

A Hybrid Lab-on-a-Chip Injector System for Autonomous Carbofuran Screening

Sensitive, simple and rapid colorimetric detection of malachite green in water, salmon and canned tuna samples based on gold nanoparticles

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