Goji berry (Lycium barbarum L.) juice reduces lifespan and premature aging of Caenorhabditis elegans: Is it safe to consume it?

Rodrigues, Cristiane de Freitas; Boldori, Jean Ramos; Soares, Marcell Valandro; Somacal, Sabrina; Emanuelli, Tatiana; Izaguirry, Aryele Pinto; Cibin, Francielli Weber Santos; Augusti, Paula Rossini; Denardin, Cristiane Casagrande

doi:10.1016/j.foodres.2021.110297

Cited by 10 publications

(9 citation statements)

References 49 publications

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“…The accumulation of lipofuscin is an important indicator of aging . Therefore, we determined the effects of different concentrations of Cers on nematode lipofuscin accumulation and body length.…”

Section: Resultsmentioning

confidence: 99%

“…The increase in the mean and maximum life span in the range of 0.10−0.50 mg/mL was Cers dose-dependent, but a transient decrease was observed at 1.25 mg/mL, which we speculate may be due to the inhibitory effect of high concentrations of Cers on the prolonged life span of C. elegans, resulting in a decreasing curve at optimal concentration. 19 Three replicates were carried out. Values with different letters in column are significantly different (p < 0.05).…”

Section: Compositional Analysis Of Cers In Sea Red Ricementioning

confidence: 99%

“…The accumulation of lipofuscin is an important indicator of aging. 19 Therefore, we determined the effects of different concentrations of Cers on nematode lipofuscin accumulation and body length. Body length and lipofuscin accumulation by nematodes after ingestion of Cers extract are shown in Figure 4.…”

Section: Cers Improved the Health Span Of C Elegansmentioning

confidence: 99%

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Ceramides from Sea Red Rice Bran Improve Health Indicators and Increase Stress Resistance of Caenorhabditis elegans through Insulin/IGF-1 Signaling (IIS) Pathway and JNK-1

Wang

Song

Jia

et al. 2022

J. Agric. Food Chem.

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The antiaging effects of sea red rice bran in vivo, a new saline-tolerant sea rice byproduct containing high levels of ceramides (Cers), remain unknown. This study aimed to explore the antiaging effects exerted by Cers from sea red rice bran on Caenorhabditis elegans, assess its health indicators as well as tolerance, and then reveal the mechanism of action of Cers in prolonging the mean life span through genetic studies. The results indicated that the mean life span of Cers-treated C. elegans were dosedependent in the range of 0.10−0.50 mg/mL. Additionally, Cers improved nematode motility, reduced lipofuscin accumulation, and enhanced resistance to heat stress and antioxidant enzyme activity. Genetic studies showed that Cers treatment had altered nematode gene expression. In addition, insulin/IGF-1 and jnk-1/mitogen-activated protein kinase (MAPK) signaling pathways successfully demonstrated the longevity effects of Cers intake. In short, these results suggest that Cers enhance the resistance of C. elegans and prolong its life span.

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Section: Resultsmentioning

confidence: 99%

Section: Compositional Analysis Of Cers In Sea Red Ricementioning

confidence: 99%

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Ceramides from Sea Red Rice Bran Improve Health Indicators and Increase Stress Resistance of Caenorhabditis elegans through Insulin/IGF-1 Signaling (IIS) Pathway and JNK-1

Wang

Song

Jia

et al. 2022

J. Agric. Food Chem.

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“…The oral administration of goji juice (GoChi) in rats demonstrated no toxicity, even at the maximum dose (10 mL/kg/day) [ 101 ]. However, high concentrations of goji juice should be carefully consumed, due to recently observed pro-oxidant effects and reducing the lifespan of the nematode Caenorhabditis elegans , a model organism for in vivo tests [ 102 ]. There are also reported cases of hepatotoxicity related to consuming goji berry [ 103 , 104 ].…”

Section: Health Benefits and Side Effects Of Goji Berry Consumptionmentioning

confidence: 99%

“…Goji berries (red and black) were used for goji juice production [ 102 , 154 ], goji tea [ 70 ], and specific fermented beverages such as fermented goji juice [ 155 , 156 , 157 , 158 ], goji wine [ 159 , 160 ], and kombucha beverages [ 161 ]. Fermented goji beverages had high TPC, TFC, and TAcy content, as well as good in vitro antioxidant properties evaluated using DPPH • , ABTS •+ , FRAP, CUPRAC, and ORAC assays [ 155 , 156 , 159 , 161 ].…”

Section: Goji Berry As Source Of Functional Ingredients In Different ...mentioning

confidence: 99%

Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review

et al. 2022

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Goji berries have long been used for their nutritional value and medicinal purposes in Asian countries. In the last two decades, goji berries have become popular around the world and are consumed as a functional food due to wide-range bioactive compounds with health-promoting properties. In addition, they are gaining increased research attention as a source of functional ingredients with potential industrial applications. This review focuses on the antioxidant properties of goji berries, scientific evidence on their health effects based on human interventional studies, safety concerns, goji berry processing technologies, and applications of goji berry-based ingredients in developing functional food products.

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Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans

et al. 2022

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Goji berry (Lycium barbarum L.) juice reduces lifespan and premature aging of Caenorhabditis elegans: Is it safe to consume it?

Cited by 10 publications

References 49 publications

Ceramides from Sea Red Rice Bran Improve Health Indicators and Increase Stress Resistance of Caenorhabditis elegans through Insulin/IGF-1 Signaling (IIS) Pathway and JNK-1

Ceramides from Sea Red Rice Bran Improve Health Indicators and Increase Stress Resistance of Caenorhabditis elegans through Insulin/IGF-1 Signaling (IIS) Pathway and JNK-1

Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review

Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans

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