Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans

Navarro-Hortal, María D.; Romero-Márquez, Jose M.; Esteban-Muñoz, Adelaida; Sánchez-González, Cristina; Rivas-García, Lorenzo; Llopis, Juan; Cianciosi, Danila; Giampieri, Francesca; Cano, Sandra; Battino, Maurizio; Quiles, José L.

doi:10.1016/j.foodchem.2021.131272

Cited by 39 publications

(34 citation statements)

References 48 publications

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“…A similar effect was reported for several compounds isolated from G. uralensis extract including glycyrrhetinic acid, isoliquiritigenin, glycyrrhizic acid and its aglycon [ 97 ], as well as ferulic acid [ 146 ], otophylloside B [ 138 ] and oleuropein aglycone [ 135 ]. This protective effect was also reported for extracts of strawberry [ 112 ] and the brown macroalga P. gymnospora [ 123 ] in the CL4176 strain. Likewise, A. tatarinowii Schott oil [ 105 ] and the extracts of coconut leaves [ 124 ] and Greek mountain tea were tested for both CL2006 and CL4176 strains, where they reduced the deposits in both strains.…”

Section: Effects Of Natural Products In Caenorhabditis Eleg...supporting

confidence: 74%

“…Some foods or other items used in gastronomy were also evaluated. These included maple syrup [ 111 ], fruits such as strawberry (Fragaria × ananassa ) [ 112 ], pomegranate ( Punica granatum L.) [ 113 , 114 ], guarana ( Paullinia cupana Kunth) [ 115 ] and cranberry ( Vaccinium ) [ 116 ], and spices such as holy basil ( Ocimum sanctum ) [ 117 ] and turmeric ( Curcuma longa L.) [ 114 ]. Other tested natural products were the extracts of flowers such as red rose ( Rosa x hybrida ) [ 118 ], roselle ( Hibiscus sabdariffa L.) [ 119 ], horned violet ( Viola cornuta ), and pansy ( Viola x wittrockiana ) [ 120 ]; essential oils from Kushui rose ( Rosa setate × Rosa rugosa ) [ 121 ]; Japanese zelkova ( Zelkova serrata (Thunb.)…”

Section: Effects Of Natural Products In Caenorhabditis Eleg...mentioning

confidence: 99%

“…The treatment with extracts of strawberry [ 112 ], guarana [ 115 ], roselle [ 119 ], Indian laburnum [ 98 ], horseradish tree [ 104 ], yerba mate [ 110 ] and “barquillo” (in both forms, hydrolyzed and not) [ 125 ], as well as various isolated compounds including caffeine [ 110 ], phosphatidylserine [ 161 ], 2,3-dehydrosilybin A/B [ 126 ] and withanolide A [ 143 ] reduced basal ROS levels in wild-type nematodes. In parallel to this, many studies also incorporated different assays to test the resistance to oxidative stress in the individuals treated with the above extracts (except for the extracts of strawberry and roselle).…”

Section: Effects Of Natural Products In Caenorhabditis Eleg...mentioning

confidence: 99%

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Natural Bioactive Products and Alzheimer’s Disease Pathology: Lessons from Caenorhabditis elegans Transgenic Models

Navarro-Hortal¹,

Romero-Márquez²,

Osta³

et al. 2022

Diseases

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Alzheimer’s disease (AD) is an age-dependent, progressive disorder affecting millions of people. Currently, the therapeutics for AD only treat the symptoms. Although they have been used to discover new products of interest for this disease, mammalian models used to investigate the molecular determinants of this disease are often prohibitively expensive, time-consuming and very complex. On the other hand, cell cultures lack the organism complexity involved in AD. Given the highly conserved neurological pathways between mammals and invertebrates, Caenorhabditis elegans has emerged as a powerful tool for the investigation of the pathophysiology of human AD. Numerous models of both Tau- and Aβ-induced toxicity, the two prime components observed to correlate with AD pathology and the ease of performing RNA interference for any gene in the C. elegans genome, allow for the identification of multiple therapeutic targets. The effects of many natural products in main AD hallmarks using these models suggest promising health-promoting effects. However, the way in which they exert such effects is not entirely clear. One of the reasons is that various possible therapeutic targets have not been evaluated in many studies. The present review aims to explore shared therapeutical targets and the potential of each of them for AD treatment or prevention.

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Section: Effects Of Natural Products In Caenorhabditis Eleg...supporting

confidence: 74%

Section: Effects Of Natural Products In Caenorhabditis Eleg...mentioning

confidence: 99%

Section: Effects Of Natural Products In Caenorhabditis Eleg...mentioning

confidence: 99%

See 1 more Smart Citation

Natural Bioactive Products and Alzheimer’s Disease Pathology: Lessons from Caenorhabditis elegans Transgenic Models

Navarro-Hortal¹,

Romero-Márquez²,

Osta³

et al. 2022

Diseases

Self Cite

View full text Add to dashboard Cite

show abstract

“…Many studies have demonstrated the usefulness of C. elegans as a tool to study the underlying mechanisms that give rise to aging-associated neurodegenerative diseases, including Alzheimer’s disease [ 139 , 140 ], and other age-related conditions like sarcopenia, because this nematode also shows loss of muscle mass with aging [ 141 ]. Moreover, C. elegans not only allows effects in behavioural and molecular improvements to be determined, but also modulation of lifespan caused by the studied substance [ 142 ].…”

Section: High-throughput Techniques and Biological Models To Study Om...mentioning

confidence: 99%

“…There are already many bioactive compounds, especially polyphenols and flavonoids derived from plant extracts [ 145 ], which have successfully demonstrated an anti-aging effect in C. elegans and curiously through a similar mechanism [ 146 ]. For example, trials with curcumin [ 147 ], Hibiscus sabdarifa extract [ 148 ], strawberry extract [ 140 ] and Ilex paraguariensis extract [ 149 ] agree in regard to the activation of the transcription factors DAF-16 and/or SKN-1 in C. elegans , which have a homologous function to FOXO and Nrf2 (encoded by NFE2L2) in humans, respectively [ 150 ]. In mammals, the FOXO factor activates the expression of genes related to longevity by promoting, among others, the synthesis of sirtuins (histone deacetylase enzymes), and the factor Nrf2 is responsible for inducing the expression of genes encoding the enzymes of the antioxidant response.…”

Section: High-throughput Techniques and Biological Models To Study Om...mentioning

confidence: 99%

Structured Long-Chain Omega-3 Fatty Acids for Improvement of Cognitive Function during Aging

Mora

Arola

Caimari

et al. 2022

IJMS

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Although the human lifespan has increased in the past century owing to advances in medicine and lifestyle, the human healthspan has not kept up the same pace, especially in brain aging. Consequently, the role of preventive health interventions has become a crucial strategy, in particular, the identification of nutritional compounds that could alleviate the deleterious effects of aging. Among nutrients to cope with aging in special cognitive decline, the long-chain omega-3 polyunsaturated fatty acids (ω-3 LCPUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have emerged as very promising ones. Due to their neuroinflammatory resolving effects, an increased status of DHA and EPA in the elderly has been linked to better cognitive function and a lower risk of dementia. However, the results from clinical studies do not show consistent evidence and intake recommendations for old adults are lacking. Recently, supplementation with structured forms of EPA and DHA, which can be derived natural forms or targeted structures, have proven enhanced bioavailability and powerful benefits. This review summarizes present and future perspectives of new structures of ω-3 LCPUFAs and the role of “omic” technologies combined with the use of high-throughput in vivo models to shed light on the relationships and underlying mechanisms between ω-3 LCPUFAs and healthy aging.

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Natural Polyphenolic Nanodots for Alzheimer's Disease Treatment

Yang,

Huang,

Zhang

et al. 2023

Advanced Materials

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The abnormal amyloid‐β accumulation is essential and obbligato in Alzheimer's disease pathogenesis and natural polyphenols exhibit great potential as amyloid aggregation inhibitors. However, the poor metabolic stability, low bioavailability, and weak blood–brain barrier crossing ability of natural polyphenol molecules fail to meet clinical needs. Here, a universal protocol to prepare natural polyphenolic nanodots is developed by heating in aqueous solution without unacceptable additives. The nanodots are able to not only inhibit amyloid‐β fibrillization and trigger the fibril disaggregation, but mitigate the amyloid‐β‐plaque‐induced cascade impairments including normalizing oxidative microenvironment, altering microglial polarization, and rescuing neuronal death and synaptic loss, which results in significant improvements in recognition and cognition deficits in transgenic mice. More importantly, natural polyphenolic nanodots possess stronger antiamyloidogenic performance compared with small molecule, as well as penetrate the blood–brain barrier. The excellent biocompatibility further guarantees the potential of natural polyphenolic nanodots for clinical applications. It is expected that natural polyphenolic nanodots provide an attractive paradigm to support the development of the therapeutics for Alzheimer's disease.

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Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans

Cited by 39 publications

References 48 publications

Natural Bioactive Products and Alzheimer’s Disease Pathology: Lessons from Caenorhabditis elegans Transgenic Models

Natural Bioactive Products and Alzheimer’s Disease Pathology: Lessons from Caenorhabditis elegans Transgenic Models

Structured Long-Chain Omega-3 Fatty Acids for Improvement of Cognitive Function during Aging

Natural Polyphenolic Nanodots for Alzheimer's Disease Treatment

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