Glycyrrhetinic Acid Hydrogen Succinate (Disodium Salt)

Brown, Holly; Christie, B.G.B.; Colin-Jones, E.; Finney, Robert; Macgregor, W.G.; Smith, J. Morrison; Smith, William G.; Sullivan, Frank; Tárnoky, A. L.; Turner, Edward; Watkinson, G.; Wotton, David

doi:10.1016/s0140-6736(59)90611-7

Cited by 13 publications

(2 citation statements)

References 7 publications

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“…Carbenoxolone (CBXH 2 ) is a semi-synthetic, commercially available anti-inflammatory drug, a succinyl derivative of GE. It was developed in the early 1960s for the management of peptic ulcers (Brown et al, 1959;Doll et al, 1965;Horwich & Galloway, 1965), but later in vitro and in vivo studies have shown its efficacy in the treatment of metabolic disorders (Dhanesha et al, 2012;Nuotio-Antar et al, 2007;Pivato et al, 2006), allergy (Heo et al, 2007), virus infection (Partridge & Poswillo, 1984) and possible application in neuroscience (Chepkova et al, 2008;Spataro et al, 2004;Tovar et al, 2009;Xu et al, 2014). Both CBXH 2 and GE are practically insoluble in water.…”

Section: Introductionmentioning

confidence: 99%

Solid-state supramolecular architecture of carbenoxolone – comparative studies with glycyrrhetinic and glycyrrhizic acids

Tykarska

Gdaniec

2015

Acta Crystallogr Sect B

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Carbenoxolone (CBXH2), a pharmaceutically relevant derivative of glycyrrhetinic acid, was studied by X-ray crystallography. The crystal structures of its unsolvated form, propionic acid and dimethoxyethane solvates and a solvated cocrystal of the free acid with its monobasic sodium salt CBXH2·CBXHNa·(butan-2-one)2·2H2O reveal that the recurring motif of supramolecular architecture in all crystal forms is a one-dimensional ribbon with closely packed triterpene fragments. It does not result from strong specific interactions but solely from van der Waals interactions. The ribbons are further arranged into diverse layer-type aggregates with a hydrophobic interior (triterpene skeletons) and hydrophilic surfaces covered with carboxylic/carboxylate groups. Solvent molecules included at the interface between the layers influence hydrogen-bonding interactions between the carbenoxolone molecules and organization of the ribbons within the layer. Comparison of crystal structures of carbenoxolone, glycyrrhizic acid and its aglycone-glycyrrhetinic acid have shown the impact of the size and hydrophilic character of the substituent at the triterpene C3 atom on the supramolecular architecture of these three closely related molecules.

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Section: Introductionmentioning

confidence: 99%

Solid-state supramolecular architecture of carbenoxolone – comparative studies with glycyrrhetinic and glycyrrhizic acids

Tykarska

Gdaniec

2015

Acta Crystallogr Sect B

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“…The first drug effective against gastric ulcer was Carbenoxolone, discovered as a result of research on a commonly used indigenous plant Glycyrrhiza glabra 10 . Herbal drugs extend the life span and makes life healthy by prevention of disease rejuvenation of our body system 11,12,13 .…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective and Antioxidant Potential of Methanol Root Extract ofTaverniera cuneifolia(Roth) Arn. in Albino Wister Rat

Jamdhade

Tembhurne²,

Kamble

et al. 2015

Journal of Biologically Active Products from Nature

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To investigate the gastro protective and antioxidant activities of methanolic extract of Taverniera cuneifolia (Roth) Arn. Gastric ulcers were produced by administration of ethanol and pylorus ligation in albino Wister rats. Free radical scavenging activity was evaluated by using DPPH, Nitric oxide, DNA Damage Scavenging methods. Taverniera cuneifolia extract treated group decreased the dose dependently gastric content, acidity, ulcer index and TBARS of gastric content. In this study the DPPH and Nitric oxide radical is significantly reduced by solvent extract and standard with increasing concentration. The maximum prevention of DNA damage was found at 4 μg/ml concentration. The gastro protective property of methanolic extract of Taverniera cuneifolia in pylorus ligation model has been demonstrated to reduce the number of ulcer and ulcer index. The present study suggests that methanolic extract of Taverniera cuneifolia roots are beneficial in the treatment of gastric ulcer.

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Biological Activity of the Terpenoids and Their Derivatives — Recent Advances

Martin‐Smith

Sneader

1969

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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Glycyrrhetinic Acid Hydrogen Succinate (Disodium Salt)

Cited by 13 publications

References 7 publications

Solid-state supramolecular architecture of carbenoxolone – comparative studies with glycyrrhetinic and glycyrrhizic acids

Solid-state supramolecular architecture of carbenoxolone – comparative studies with glycyrrhetinic and glycyrrhizic acids

Gastroprotective and Antioxidant Potential of Methanol Root Extract ofTaverniera cuneifolia(Roth) Arn. in Albino Wister Rat

Biological Activity of the Terpenoids and Their Derivatives — Recent Advances

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