Glycine ameliorates liver injury and vitamin D deficiency induced by bile duct ligation

Chen, Chiung Yu; Wang, Bei Tzu; Wu, Z. C.; Yu, Wen Ting; Lin, Po Ju; Tsai, Wan-Ting; Shiesh, Shu Chu

doi:10.1016/j.cca.2012.10.016

Cited by 13 publications

(13 citation statements)

References 30 publications

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“…The immune protective function of glycine may be related to reduced levels of pro-inflammatory cytokines and elevated levels of anti-inflammatory cytokines in the plasma, which interfere with TNF-α/NF-κB signal transduction pathways [89]. Similarly, glycine protects the liver from bile duct ligation-induced injury through alleviating oxidative stress and apoptosis [90]. Additionally, glycine inhibits the secretion of very low density lipoprotein from the liver of rats fed a high-fat diet [91].…”

Section: Accepted Manuscriptmentioning

confidence: 97%

Nutritional epigenetics with a focus on amino acids: implications for the development and treatment of metabolic syndrome

Dai

et al. 2016

The Journal of Nutritional Biochemistry

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Section: Accepted Manuscriptmentioning

confidence: 97%

Nutritional epigenetics with a focus on amino acids: implications for the development and treatment of metabolic syndrome

Dai

et al. 2016

The Journal of Nutritional Biochemistry

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“…Some food items and supplements also possess the potential to reduce vitamin D deficiency. Glycine has potential to provide protection against bile duct ligation induced liver injury by decreasing oxidative stress, apoptosis and vitamin D deficiency [ 114 , 115 ] . Breastfed infants should get at least10–20 min exposure to the sun to ensure sufficient intake of vitamin D as breast milk is devoid of this vitamin.…”

Section: Factors Contributing Towards Vitamin D Deficiency and Its Smentioning

confidence: 99%

Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D

et al. 2018

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BackgroundLiver dysfunction is a topic of global concern with many advancing therapies being researched. Though vitamin D takes a center place, other therapies especially nutritional are also gaining ground. Vitamin D has gone beyond its role in skeletal disorders by showcasing its associations in other metabolic dysfunctions too.ResultEpidemiological evidences show a correlation between the status of vitamin D and different forms of cancer. Vitamin D receptors and alterations in gene expression appear decisive in the development of chronic liver disorders. Nutritional status therefore plays a significant role in avoiding the complications related to liver dysfunctions, making it mandatory in maintaining vitamin D sufficiency in the body. Therapies with omega-3 fatty acids, antioxidants, amino acids, steroids also render benefits which could be further explored. Recent research on the progression of certain forms of liver cancer using vitamin D analogs like Seocalcitol EB 1089 has shown good promise.ConclusionThe anti-inflammatory and immuno- regulatory properties of vitamin D makes its analogs, suitable candidates of better choice for the prevention and treatment of liver disorders and cancer.

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“…Glycine exerts anti-inflammatory, cytoprotective, and immunomodulatory properties and ameliorates liver injury through attenuation of oxidative stress, apoptosis [46]. Homocysteine (HCY) is a sulfur-containing amino acids, mainly derived from S-adenosyl homocysteine generated by S-adenosylmethionine methyltransferase, and mainly completed catabolism in the liver [47].…”

Section: Discussionmentioning

confidence: 99%

Differences in Metabolites of Different Tongue Coatings in Patients with Chronic Hepatitis B

Zhao

Gou

Dai

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Tongue coating is one of the important foundations of tongue diagnosis in traditional Chinese medicine (TCM) and plays an important role in reflecting the occurrence, development, and prognosis of the disease. However, its material basis is still poorly understood. In this study, a urinary metabonomic method based on gas chromatography coupled to mass spectrometry (GC/MS) was developed. The distinct clustering in metabolic profile was observed from Group A (thick yellow coating in patients with chronic hepatitis B), Group B (thick white coating in patients with chronic hepatitis B), and Group C (thin white coating with healthy humans) using orthogonal projections to latent structures (OPLS). Based on the variable of importance in the project (VIP) values, some significantly changed metabolites have been identified. These changes were related to the disturbance in energy metabolism, amino acid metabolism, nucleotide metabolism, and gut microflora, which were helpful to understand the material basis leading to the formation of tongue coating. This study demonstrated that tongue coating may have an objective material basis.

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Glycine ameliorates liver injury and vitamin D deficiency induced by bile duct ligation

Cited by 13 publications

References 30 publications

Nutritional epigenetics with a focus on amino acids: implications for the development and treatment of metabolic syndrome

Nutritional epigenetics with a focus on amino acids: implications for the development and treatment of metabolic syndrome

Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D

Differences in Metabolites of Different Tongue Coatings in Patients with Chronic Hepatitis B

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