Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D

Abstract

BackgroundLiver dysfunction is a topic of global concern with many advancing therapies being researched. Though vitamin D takes a center place, other therapies especially nutritional are also gaining ground. Vitamin D has gone beyond its role in skeletal disorders by showcasing its associations in other metabolic dysfunctions too.ResultEpidemiological evidences show a correlation between the status of vitamin D and different forms of cancer. Vitamin D receptors and alterations in gene expression appear decisive in the development of chronic liver disorders. Nutritional status therefore plays a significant role in avoiding the complications related to liver dysfunctions, making it mandatory in maintaining vitamin D sufficiency in the body. Therapies with omega-3 fatty acids, antioxidants, amino acids, steroids also render benefits which could be further explored. Recent research on the progression of certain forms of liver cancer using vitamin D analogs like Seocalcitol EB 1089 has shown good promise.ConclusionThe anti-inflammatory and immuno- regulatory properties of vitamin D makes its analogs, suitable candidates of better choice for the prevention and treatment of liver disorders and cancer.

Neuromuscular Weakness Syndromes from Immune Checkpoint Inhibitors: A Case Series and Literature Review

“…Early diagnosis, optimizing vitamin D status, and early initiation of immunosuppressive therapy are recommended. The potential role of low vitamin D status to cause muscle weakness especially in cancer patients and possible positive immunomodulatory effects were considered [74,75] for the above recommendations. IVIg induction dose of 2 g/kg divided over 2-5 days and maintenance 1 g/kg, with a maximum of 60 g given every 2-3 weeks depending to the clinical response, can be considered.…”

Correction to: Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D

“…Following publication of the original article [ 1 ] one of the authors wrote to say that his name had been spelt incorrectly as Ahmed Makki instead of Ahmad Makki.…”

Vitamin D Deficiency Did Not Augment the Progression of High-Fructose-Induced Nonalcoholic Fatty Liver Disease in Rats

“…Additionally, it has multiple functions and target organs and influences the expression of several genes and plays important roles in the regulation of cell proliferation and differentiation, immune function, oxidative stress, protein glycation, inflammation, and apoptosis (7)(8)(9). Therefore, Vit D has been reported to be effective in preventing many diseases such as diabetes, hypertension, cardiovascular and hepatic diseases and cancer (10)(11)(12).…”

“…Although there are some differences in clinical guidelines, the Institute of Medicine (Washington; USA) defines VDD as a 25(OH)D level of <20 ng/mL and severe VDD as <10 ng/mL (15). VDD alone may induce IR, oxidative stress, inflammation, and mitochondrial dysfunction (8,10,14). However, epidemiological and laboratory evidence have shown that VDD may be associated with some common diseases such as tumors, bone diseases, immune disorders, cardiovascular diseases, diabetes mellitus, and chronic liver disorders (12)(13)(14).…”

“…However, epidemiological and laboratory evidence have shown that VDD may be associated with some common diseases such as tumors, bone diseases, immune disorders, cardiovascular diseases, diabetes mellitus, and chronic liver disorders (12)(13)(14). VDD has also been reported to be a secondary factor in the onset and progression of NAFLD, but a clear result has not been reached in clinical and experimental studies (7,10,11,16,17).…”