Glycerol Levels in the Maternal and Umbilical Cord Blood under Various Conditions

Sabata, V; Wolf, H; Lausmann, S

doi:10.1159/000240217

Cited by 12 publications

(6 citation statements)

References 3 publications

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“…Our finding of no significant arterio-venous difference for glycerol concentrations in cord blood was in agreement with previously reported results (44). In contrast to one (43), but in agreement with other reports (9, 12), were the higher concentrations of FFA in umbilical venous rather than arterial blood.…”

Section: Acta Prediat Scand 60supporting

confidence: 94%

Influence of Environmental Temperature and Acidosis on Lipid Mobilization in the Human Infant During the First Two Hours After Birth

Persson

Tunell

1971

Acta Paediatrica

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Arterial concentrations of glycerol, FFA, glucose, lactate and β‐hydroxybutyrate were serially measured during the first two hours after birth in normal fullterm infants in a thermo‐controlled environment. Blood gas tensions, acid‐base balance, pulmonary gas exchange, motor activity and heart rate were also determined: a detailed report of these data will be published separately. In 22 infants the glycerol concentrations showed a rapid immediate increase after birth wheras the rises in FFA concentrations were delayed until between 30 and 120 minutes, indicating a prompt increase in lipolysis and a suppression of lipid mobilization during the first half hour after birth. This suppression might be explained by a high rate of reesterification or oxidation of FFA within adipose tissue. The influence of environmental temperature (2 8.7‐3 4.8 oC) and degree of acidosis on the pattern of changes in FFA and glycerol were only marginal. No inhibition of lipolysis and lipid mobilization was shown in an infant who developed postnatal asphyxia.At 120 min after birth, when acidosis had been eliminated, an inverse correlation was found between the rise in FFA from birth to 120 min and the respiratory exchange ratio (V̇co2/V̇o2).The glucose concentrations were related neither to the FFA nor to the glycerol concentrations. The rate of elimination of lactate and β‐hydroxybutyrate was not influenced by environmental temperature or acidosis. Minute amounts of administered heparin caused an increased rise in FFA and glycerol concentrations which were associated with the appearance of lipoprotein lipase activity.

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Section: Acta Prediat Scand 60supporting

confidence: 94%

Influence of Environmental Temperature and Acidosis on Lipid Mobilization in the Human Infant During the First Two Hours After Birth

Persson

Tunell

1971

Acta Paediatrica

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“…3). A gradient of glycerol between maternal and fetal blood observed in these two species (Table 2) was also noted in the human fetus by Sabata et al (24). However, these authors could not establish a transfer when they studied the correlation between maternal and fetal glycerol levels.…”

Section: Placental Transfer O F Glycerolsupporting

confidence: 55%

Origin and Metabolic Fate of Plasma Glycerol in the Rat and Rabbit Fetus

Gilbert

1977

Pediatr Res

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“…At birth, the glucose supply from the mother suddenly ceases and within a few hours there is a dramatic rise in plasma triglycerides and NEFA [9], This bio chemical change is thought to result from lipolysis of fetal adipose tissue and to be mediated by the release of catecholamines [10], Lipolysis may also be responsible for the high NEFA, glycerol and triglyceride lev els found in cord blood samples from as phyxiated neonates at birth [11][12][13]. Thus, it is thought that in the presence of perinatal asphyxia glycogen stores are rapidly depleted and lipids are mobilized from fat stores to provide substrate for oxidation [11], How ever, in our study, the fetal plasma levels of NEFA and glycerol were not increased and there was no correlation between hypoglyce mia and hypertriglyceridemia, suggesting that in chronic intrauterine hypoxemia and hypoglycemia the major cause of the ob served hypertriglyceridemia is unlikely to be increased lipolysis.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Hypertriglyceridemia in Small for Gestational Age Fetuses

Economides

Crook²,

Nicolaides³

1988

Fetal Diagn Ther

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Plasma triglyceride, nonesterified fatty acid (NEFA), glycerol, insulin and blood glucose concentrations were measured in 32 small for gestational age (SGA) and 54 appropriate for gestational age fetuses. Although the values of plasma NEFA and glycerol concentrations were not different in the two groups, some SGA fetuses were hypertriglyceridemic, hypoglycemic and hypoinsulinemic. These findings suggest that hypertriglyceridemia in hypoxemic SGA fetuses is not due to lipolysis, nor to increased triglyceride synthesis, but rather to impaired utilization of circulating triglycerides.

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Glycerol Levels in the Maternal and Umbilical Cord Blood under Various Conditions

Cited by 12 publications

References 3 publications

Influence of Environmental Temperature and Acidosis on Lipid Mobilization in the Human Infant During the First Two Hours After Birth

Influence of Environmental Temperature and Acidosis on Lipid Mobilization in the Human Infant During the First Two Hours After Birth

Origin and Metabolic Fate of Plasma Glycerol in the Rat and Rabbit Fetus

Investigation of Hypertriglyceridemia in Small for Gestational Age Fetuses

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