Investigation of Hypertriglyceridemia in Small for Gestational Age Fetuses

Economides, D. L.; Crook, David; Nicolaides, Kypros H.

doi:10.1159/000263349

Cited by 22 publications

(13 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One band at 37 kDa was detected by Western blot for LPL. No significant differences were detected in LPL protein expression (18 Intralipid treatment. Cytotrophoblast cells incubated in 40 and 400 mg/dl Intralipid for 24 h showed a 28 -39% decrease in LPL activity compared with control (n ϭ 10 -14, P Ͻ 0.05, one-way ANOVA; Fig.…”

Section: Lpl Activity and Protein And Mrna Expression In Cytotrophoblmentioning

confidence: 75%

Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency

Magnusson-Olsson¹,

Lager²,

Jacobsson³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

Section: Lpl Activity and Protein And Mrna Expression In Cytotrophoblmentioning

confidence: 75%

Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency

Magnusson-Olsson¹,

Lager²,

Jacobsson³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

“…Cordocentesis data on fetal plasma from 18 to 36 weeks indicate an exponential fall in the concentration of circulating NEFA in the fetal circulation over this period (41), presumably because of the rapidly increasing fetal demand for fatty acids (Figure 4c). The concentration of NEFA in the maternal plasma at term is around three times that in the fetal circulation, but the concentration of albumin, its primary carrier protein, is actually 10%-20% higher in the fetal than in the maternal circulation (4).…”

Section: The Driver Of Placental Fatty Acid Transportmentioning

confidence: 99%

Fatty Acid Supply to the Human Fetus

2010

View full text Add to dashboard Cite

Deposition of fat in the fetus increases exponentially with gestational age, reaching its maximal rate-around 7 g/day or 90% of energy deposition-at term. In late pregnancy, many women consuming contemporary Western diets may not be able to meet the fetal demand for n-3 long chain polyunsaturated fatty acids (LCPUFAs) from the diet alone. Numerous mechanisms have evolved to protect human offspring from extreme variation or deficiency in the maternal diet during pregnancy. Maternal adipose tissue is an important source of LCPUFA. Temporal changes in placental function are synchronized with maternal metabolic and physiological changes to ensure a continuous supply of n-3 and n-6 LCPUFA-enriched fat to the fetus. LCPUFA storage in fetal adipose tissue provides an important source of LCPUFA during the critical first months of postnatal life. An appreciation of these adaptations is important in any nutritional strategy designed to improve the availability of fatty acids to the fetus.

show abstract

“…retarded human and rat pregnancies [25,[33][34][35]. However, Spencer et al [26] reported similar values for insulin, proinsulin, and des 31, 32 proinsulin in the cord blood of small for gestational age (SGA) babies.…”

mentioning

confidence: 99%

Differential Expression of Glucose Transporters in Rabbit Placenta: Effect of Hypercholesterolemia in Dams1

Kevorkova

Éthier-Chiasson

Lafond

2007

Biology of Reproduction

View full text Add to dashboard Cite

Low birth weight is observed in rabbit offspring when maternal hypercholesterolemia is induced during gestation, but the related etiology is still unknown. Glucose is one of the most important substances during fetal development, and defect in glucose supply to fetus was related to pathophysiological mechanisms in intrauterine growth restriction. Thus, the aim of this work was to evaluate the impact of maternal hypercholesterolemia during rabbit gestation on the glucose metabolism and the routing of glucose transporters (SLC2 and SLC5 [previously known as GLUT and SGLT]) in placenta. In this study, maternal and offspring serum levels of glucose and insulin were evaluated for control and hypercholesterolemic groups, and the mRNA and protein expressions of placental SLCs were quantified by real-time RT-PCR and Western immunoblot, respectively. Our data demonstrate that maternal hypercholesterolemia during gestation: 1) induces offspring hypoglycemia; 2) does not modify the genetic and protein expressions of SLC2A1 and SLC2A4 (previously GLUT1 and GLUT4) in total placental extract; 3) downregulates the placental SLC5A1 (previously SGLT1) protein expression without affecting its mRNA levels; 4) impairs the translocation of SLC2A1 but not SLC2A4 from cytoplasmatic pool to the cell membrane surface. Then we assume that reduction of offspring birth weight in presence of maternal hypercholesterolemia may be related to the offspring's hypoglycemia and the reduction of the cell surface expression of placental SLC2A1.

show abstract

Investigation of Hypertriglyceridemia in Small for Gestational Age Fetuses

Cited by 22 publications

References 17 publications

Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency

Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency

Fatty Acid Supply to the Human Fetus

Differential Expression of Glucose Transporters in Rabbit Placenta: Effect of Hypercholesterolemia in Dams1

Contact Info

Product

Resources

About