Glycerin prevents the ‘heat-death’ of ehrlich ascites tumor cells

Fekete, István

doi:10.1007/bf01939644

Experientia

1978

DOI: 10.1007/bf01939644

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Glycerin prevents the ‘heat-death’ of ehrlich ascites tumor cells

István Fekete

Abstract: When heated to 45 degrees C for 20 min Ehrlich ascites tumor and NK-lymphoma cells are irreversibly damaged, so that they lose transplantability. The presence of 7-8% glycerol during heat treatment protects EAT cells completely and NK-lymphoma cells partly against this injury.

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1981

1992

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Cited by 6 publications

References 22 publications

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Evidence for separate modes of action in thermal radiosensitization and direct thermal cell death

Mivechi¹,

Hofer²

1983

Cancer

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It is not known whether heat potentiation of radiation damage and direct heat death are mediated by the same or by different heat lesions within the cell. In this study, three types of experiments were performed on BP‐8 murine sarcoma cells to provide evidence against a common mode of action: (1)Evaluation of the kinetics of cell death from heat, radiation, and combined heat‐radiation treatments: direct heat death is rapid and essentially complete within 24‐48 hours after heat exposure, whereas radiation death develops only after a delay period of several days. Radiosensitization by heat affects only the delayed component of cell death, that is, the radiation component of death. (2)Thermal radiosensitization and direct heat death as a function of heating time: thermal radiosensitization requires only short exposures to heat; prolonged heating does not further enhance this effect. In contrast, direct heat death increases with increasing duration of heat exposure. (3)Independent modification of radiosensitization and thermal death: addition of 5% glycerol to the incubation medium protects cells against direct heat death, but not against thermal radiosensitization. In combination, these findings suggest that heat potentiation of radiation lethality and direct heat death are two distinct phenomena mediated by different cellular mechanisms.

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Evidence for separate modes of action in thermal radiosensitization and direct thermal cell death

Mivechi¹,

Hofer²

1983

Cancer

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Protection of heat induced cytoxicity by glycerol

Lin

Kwock

Hefter

1981

Journal Cellular Physiology

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Glycerol, at concentrations of 2-10% is a potent hyperthermic (43 degrees - 45 degrees C)protector of cultured Chinese hamster cells, V79. Furthermore, the sensitization effect of low pH on heat death is also drastically reduced by the addition of glycerol into the culture medium. Together with the known cellular effects of heat and the role of glycerol in various cellular structures and functions, the data suggest that microtubules and membranes may be involved in the expression of heat-induced cell death.

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Effect of membrane and cytoskeleton modification on the heat response of BP-8 murine sarcoma cells

1989

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Glycerin prevents the ‘heat-death’ of ehrlich ascites tumor cells

Abstract: When heated to 45 degrees C for 20 min Ehrlich ascites tumor and NK-lymphoma cells are irreversibly damaged, so that they lose transplantability. The presence of 7-8% glycerol during heat treatment protects EAT cells completely and NK-lymphoma cells partly against this injury.

Cited by 6 publications

References 22 publications

Evidence for separate modes of action in thermal radiosensitization and direct thermal cell death

Evidence for separate modes of action in thermal radiosensitization and direct thermal cell death

Protection of heat induced cytoxicity by glycerol

Effect of membrane and cytoskeleton modification on the heat response of BP-8 murine sarcoma cells

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