Effect of membrane and cytoskeleton modification on the heat response of BP-8 murine sarcoma cells

Fever's Glass Ceiling

“…Yatvin and Cramp [30] have recently concluded from their own work and a review of the literature that, rather than protein denaturation per se, alterations in the fluidity of cell membranes that result from an increase in the content of cholesterol, phospholipids, and protein is the critical cellular derangement induced by hyperthermia. Other researchers have pointed to degradation of DNA, inhibition of DNA synthesis, induction of chromosomal aberrations [31][32][33][34], inhibition ofprotein synthesis [35,36], protein denaturation [37], increased protein phosphorylation [38], increased lysosomal enzyme activity [39][40][41], alterations in cytoskeletal and structural proteins [42][43][44][45][46][47], and increases in intracellular free calcium in association with relocation of kinase C [48 -51] as events contributing to the adverse effects of hyperthermia. More than likely, multiple adverse cellular events are triggered simultaneously by temperatures of >42°C, and together these events mediate the cellular dysfunction and death due to hyperthermia.…”