Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population

Zong, Chen; Sha, Yanwei; Xiang, Hui-Xian; Wang, Jing; Chen, Dawei; Liu, Juan; Wang, Binbin; Cao, Yunxia

doi:10.1007/s10815-013-0163-2

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…The distributions of allele frequencies differ across ethnicities. Regarding GSTA1, the current analysis reported the frequency of GSTA1*B at around 16.9% which is 2-3 times lower than reported in Caucasians [19,[30][31][32][33][34], but similar to other Asian populations, such as the Chinese [21,35,36], Koreans [37], and Japanese [22,38]. Two SNPs detected in GSTA1, G-52A (rs3957356) and C-69T (rs3957357), are in a full linkage disequilibrium, in line with other populations, such as Caucasians [19,34], Koreans [30] and Chinese [21].…”

Section: Discussioncontrasting

confidence: 49%

Effect of GSTA1 Variants on Busulfan-Based Conditioning Regimen Prior to Allogenic Hematopoietic Stem-Cell Transplantation in Pediatric Asians

et al. 2022

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Busulfan is widely used as a chemotherapy treatment before hematopoietic stem-cell transplantation (HSCT). However, the response of busulfan is highly variable and unpredictable, whereby the pharmacogenetic interference of glutathione S-transferase (GST) has strong evidence in Caucasians and some adult Asians but not in pediatric Asian patients. This study was aimed at investigating the associations of GST genetic polymorphisms with variations in the pharmacokinetic (PK) properties of busulfan in pediatric Asian patients. This retrospective cohort study recruited 92 pediatric patients. The polymorphism of GSTA1 was genotyped by Sanger sequencing, and GSTM1 and GSTP1 were genotyped by real-time PCR. Drug concentration and PK estimation were identified using an LC-MS/MS method and a noncompartmental model. Statistical analysis was performed by R software. Out of 92 patients, 48 (53%) were males, the mean age was 8.4 ± 5.12 years old, and the average weight was 26.52 ± 14.75 kg. The allele frequencies of GSTA1*B and of GSTM1 and GSTP1* deletions were 16.9%, 68.5%, and 21.2%, respectively. Patients with GSTA1*B had a statistically significant impact on the PK of busulfan, whereas those with GSTM1 and GSTP1 did not (p > 0.05). The carriers of GSTA1*B showed a significant difference compared to noncarriers in terms of t1/2 (for first dose: 161.9 vs. 134.3 min, p = 0.0016; for second dose: 156.1 vs. 129.8, p = 0.012), CL (88.74 vs. 124.23 mL/min, p = 0.0089), Cmax (4232.6 vs. 3675.5 ng/mL, p = 0.0021), and AUC (5310.6 vs. 4177.1 µM/min, p = 0.00033). The augmentation of AUC was around 27.1% in patients carrying the GSTA1*B variant. The GSTA1 polymorphism was significantly associated with variations of the pharmacokinetic properties of busulfan treatment in pediatric Asian patients.

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Section: Discussioncontrasting

confidence: 49%

Effect of GSTA1 Variants on Busulfan-Based Conditioning Regimen Prior to Allogenic Hematopoietic Stem-Cell Transplantation in Pediatric Asians

et al. 2022

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“…Determinants of the production of an increased number of ROS and disorders caused by them can be environmental pollution, chronic stress, low levels of physical activity, teratogenic effect of drugs and chemicals, or improper nutrition. It causes abnormalities in the structure of DNA that can lead to early miscarriages, preeclampsia, fetal growth restriction, fetal abnormalities, and birth defects [ 31 – 33 ].…”

Section: Oxidative Stress In Pregnancy Completed With Birth Defectmentioning

confidence: 99%

Association of Oxidative Stress on Pregnancy

Toboła-Wróbel

Pietryga

Dydowicz

et al. 2020

Oxidative Medicine and Cellular Longevity

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The pathophysiological mechanism underlying pregnancy complications such as congenital malformations, miscarriage, preeclampsia, or fetal growth restriction is not entirely known. However, the negative impact of the mother’s body oxidative imbalance on the fetus and the course of gestation is increasingly discussed. This article is an integrative review of some original studies and review papers on the effects of oxidative stress on the adverse pregnancy outcomes mainly birth defects in fetuses. A systematic search for English language articles published from 2010 until 2020 was made, using MEDLINE data. Additionally, we analyzed the Cochrane and Scopus databases, discussions with experts, and a review of bibliography of articles from scientifically relevant and valuable sources. The main purposes are to assess the contribution of the existing literature of associations of oxidative stress on the etiology of the abovementioned conditions and to identify relevant information and outline existing knowledge. Furthermore, the authors aim to find any gaps in the research, thereby providing grounds for our own research. The key search terms were “oxidative stress in pregnancy,” “oxidative stress and congenital malformations,” and “oxidative stress and adverse pregnancy outcomes.” Studies have confirmed that oxidative stress has a significant impact on pregnancy and is involved in the pathomechanism of adverse pregnancy outcomes.

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“…The frequencies of genotype and allele of GSTA1 -69C>T polymorphism have been reported in diverse populations. The findings obtained for the Turkish population were compared with the results reported for various populations [4,6,8,9,[12][13][14][15][16][17][18][19][20][21][22][23][24][25] as depicted in Table 2. Accordingly, GSTA1 -69T variant allele was more frequent in South Tunisians and Germans compared to other populations.…”

Section: Discussionmentioning

confidence: 99%

Frequencies of glutathione S-transferase A1 rs3957357 polymorphism in a Turkish population

Şahinoğulları¹

2021

Journal of Surgery and Medicine

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Background/Aim: Glutathione-S-transferases (GSTs), a major group of phase II enzymes, play a significant role in the detoxification and metabolism of endogenous and exogenous compounds. The objective of the survey was to identify the distribution of genotype and allele frequencies of GSTA1 -69C>T (rs3957357) polymorphism in a healthy Turkish population and compare the determined frequencies with those in various populations. Methods: Polymerase chain reaction and restriction fragment length polymorphism methods were used to analyze GSTA1 -69C>T polymorphism in DNA samples of 105 healthy Turkish individuals. Results: The distribution of GSTA1 CC, CT, and TT genotype frequencies were 32.4%, 48.6% and 19.0%, respectively while the allele frequencies were 56.7% for C allele and 43.3% for T allele. The findings obtained were compared with the results of various populations. The frequencies of GSTA1 -69C>T polymorphism were similar to those of the African American population and the populations with White ancestry, but significantly different from those reported for the populations with Asian ancestry. Conclusion:To the best of our knowledge, this is the first study to present the frequencies of the GSTA1 -69C>T polymorphism among Turkish individuals. The findings of the current study may provide a perspective for further studies exploring the role of GSTA1 -69C>T polymorphism on predisposition to diverse illnesses such as cancer and may be used as a control group for such studies. In addition, this study might contribute to epidemiological and toxicogenetic investigations.

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Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population

Cited by 9 publications

References 21 publications

Effect of GSTA1 Variants on Busulfan-Based Conditioning Regimen Prior to Allogenic Hematopoietic Stem-Cell Transplantation in Pediatric Asians

Effect of GSTA1 Variants on Busulfan-Based Conditioning Regimen Prior to Allogenic Hematopoietic Stem-Cell Transplantation in Pediatric Asians

Association of Oxidative Stress on Pregnancy

Frequencies of glutathione S-transferase A1 rs3957357 polymorphism in a Turkish population

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