Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis

Abstract

Abnormality of glutathione peroxidase (GPx) is involved in the etiology and pathogenesis of vitiligo. However, the results were controversial. Aim. The purpose of this meta-analysis is to compare the levels of GPx between vitiligo patients and healthy controls. Methods. Relevant published articles were searched according to eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% confidence interval (CI). Results. Twenty-three studies with a total of 1076 vitiligo patients and 770 healthy controls were included. The pooled meta-analysis showed that patients with vitiligo had equivalent levels of GPx with the healthy controls (SMD = −0.47, 95% CI: −1.03 to 0.08, and p = 0.095). Further subgroup analysis showed that the GPx levels of Asian patients or segmental vitiligo patients were, respectively, lower than those of healthy controls (Asian: SMD = −0.47, 95% CI: −1.08 to 0.14, and p = 0.001; segmental: SMD = −3.59, 95% CI: −6.38 to −0.80, and p = 0.012). Furthermore, the GPx levels in serum/plasma were significantly decreased in either stable or active vitiligo patients, comparing to healthy controls (stable: SMD = −2.01, 95% CI: −3.52 to −0.49, and p = 0.009; active: SMD = −2.34, 95% CI: −4.07 to −0.61, and p = 0.008). Conclusion. This meta-analysis showed a significant association between low GPx level and vitiligo.

Ginkgo biloba extract protects human melanocytes from H2O2‐induced oxidative stress by activating Nrf2

“…In the present study, we initially found that EGb761 showed no toxic effect on PIG1 cells (data not shown), which was consistent with previous studies . The patients with vitiligo have inferior capacity against oxidative stress due to the lower activity of SOD and GSH‐Px . Our study showed that EGb761 could significantly restore the activity of SOD and GSH‐Px in PIG1 cells under H 2 O 2 treatment.…”

“…10 The patients with vitiligo have inferior capacity against oxidative stress due to the lower activity of SOD and GSH-Px. 20,21 Our study showed that EGb761 could significantly restore the activity of SOD and GSH-Px in PIG1 cells under H 2 O 2 treatment.…”

“…Previous studies have indicated that the imbalance in redox state is involved in the pathogenesis of vitiligo. 14,20,21 (Figure 2A,B).…”

Glutathione Peroxidase in Health and Diseases

“…It showed a significant relationship between low GPx level and vitiligo. Asian vitiligo patients showed lower levels of GPx than the controls, Caucasian populations, and healthy controls [81]. GPx polymorphism may contribute to the reduced GPx activity and the prevalence of vitiligo in Gujarat population [82].…”

Functional nutrition as integrated approach in vitiligo management

“…The expression level and activity of GPx are decreased in blood and skin of vitiligo patients (Xiao et al, 2016), and the genetic association of vitiligo with variations in GPx gene was confirmed by Mansuri et al (2017). Thioredoxin reductase (TxR) reduces the LMWA thioredoxin repristinating its ROS scavenging activity.…”